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Longevity born in Switzerland

Resveratrol and its anti-ageing benefits

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Many of us have toasted to red wine in the name of good health before. To be fair, it has been touted for its benefits for several years now, but what really gives red wine its therapeutic effects? Experts believe that Resveratrol - a well-recognised antioxidant - may be the key compound. 
So, before you uncork your next favourite bottle of wine, explore the science behind this precious molecule, and learn about its health-boosting powers against ageing.

 

What is Resveratrol?

Resveratrol is a polyphenol produced by plants to act as a natural defence system against environmental stressors. It is commonly found in Japanese knotweed and a variety of foods, including grapes, peanuts, and berries.

Fun fact: Japanese knotweed is a plant which has been used in traditional Chinese medicine for several years. It is considered to be the richest source of Resveratrol.

In 1992, Resveratrol gained considerable interest after being linked to the cardioprotective effects of red wine. Ever since, more than 12,000 scientific papers about Resveratrol have been published in preventing or slowing down the progression of multiple illnesses, including cancer, cardiovascular disease and ischaemic injuries. It has also been shown to decrease stress and extend lifespans of diverse organisms from yeasts to vertebrates. 

 

Trends on Resveratrol graph

 

Current ageing situation 

As improvements in health care have helped increase human life expectancy, ageing populations are growing rapidly. Unfortunately, this also means increasing spans of poor health and disability that often come with ageing. 

Our era is thus challenged with reducing the impact of ageing on health and preventing age-related illnesses from developing.

 

Ageing as the foundation of diseases

 

Benefits of Resveratrol

A plethora of research now shows how natural compounds like Resveratrol could be a safe and effective strategy when it comes to enhancing longevity and minimising the risk of age-related diseases. 

 

The benefits of Resveratrol

 

Resveratrol is impactful in ageing treatment as it suppresses oxidative stress, relieves inflammatory reaction, improves mitochondrial function, and regulates apoptosis[1]. Recent studies also claim its interaction with the gut to be beneficial[2].

Sit back and relax, as we delve into the significance of this incredible, plant-derived natural compound.

Resveratrol

 

Effect on lifespan

Studies on model organisms showed that Resveratrol promotes longevity by inducing Sirt-1 dependent autophagy[3]. As complex as it sounds, let's try to understand the actions of Resveratrol at the molecular level.

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Autophagy is a process that stimulates the clearance of impaired cellular organelles (specialised structures that perform different functions inside your cells), and dysfunctional proteins. It is crucial in promoting cell survival and facilitating a stable internal cellular environment[4]. A study has shown how Resveratrol may induce autophagy in human cells in vitro and promote lifespan in C. elegans in vivo[5]. 

 

Older woman having fun 

Fun fact: C elegans is an invaluable animal for ageing research, as its studies have led to the identification of hundreds of genes and treatments that modulate lifespan[6].

Sirt-1 is a gene well-documented to be linked with ageing and longevity. Recent investigations suggest that Resveratrol is one of the most potent instigators of Sirt-1 activity amongst all plant polyphenols. It provides anti-ageing effects through mechanisms similar to caloric restriction, another well-recognised intervention proposed to delay ageing and increase lifespan[5].

 

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Effect on neurodegenerative disease

Man studying

 

Ageing is reported to be the number one risk factor for neurodegenerative diseases, affecting millions of people worldwide. Cellular and molecular changes that occur with ageing lead to the progressive loss of memory and motor impairment. This eventually raises the risk of neurodegenerative diseases like Alzheimer’s disease, Parkison’s disease, and dementia[7,8].

Resveratrol demonstrated protective effects against such neurodegenerative diseases by enhancing the secretion of neurotransmitters (important chemical messengers in your brain cells), promoting neurogenesis (brain cells production), and decreasing neuroinflammation and oxidative stress[7,8]. 

 

"Ageing might even be ‘’the’’ major carcinogen. Besides, with the intrinsic cellular changes that come with ageing, our immune system becomes less effective at detecting and fighting diseases, including cancer."

NCI Director, Dr. Norman E. Sharpless

 

Effect on cardiovascular disease

Older couple running

 

The leading cause of death worldwide is cardiovascular disease, and ageing is one of its primary contributors. Ageing is associated with altered redox balance, and damaged vascular function that increases the occurrence of such diseases. For instance, ageing can cause large vessels on the heart’s surface to constrict, resulting in endothelial dysfunction, an early marker for atherosclerosis[9,10].

Resveratrol can protect against ageing-associated vascular diseases like atherosclerosis through multiple studied mechanisms. It reduces superoxide (detrimental radicals) generation, improves oxidative stress, and regulates the renin-angiotensin system[11]. Resveratrol has also been shown to restore the activity of Sirt-1, a specific sirtuin-coding gene, which results in gene expressions and anti-ageing metabolic pathway activation[5].

 

Effect on cancer

Resveratrol's effects on Cancer

 

It is now clear how ageing can affect the onset and progression of cancer. They share several mechanisms in common, including genomic instability, telomere attrition, epigenetic changes, loss of proteostasis(protein regulation), decreased nutrient sensing, altered metabolism as well as cellular senescence (a state where your cells are inactive but refuse to die)[12]. 

According to the NCI Director, Dr. Norman E. Sharpless, ageing might even be ‘’the’’ major carcinogen. Besides, with the intrinsic cellular changes that come with ageing, our immune system becomes less effective at detecting and fighting diseases, including cancer.

 

Resveratrol has been found to inhibit tumour progression by suppressing cell proliferation and metastasis (when cancer spreads to a different body part from where it started). Further studies in human colon cancer cell lines have also revealed how Resveratrol can induce apoptotic cell death, a process that eliminates damaged, virus-infected and cancer cells[13].

 

Effect on bone health

Man holding weights

 

Osteoporosis is a common disease of old age, characterised by a decrease in bone density and mass, and an increase of bone brittleness[14]. A study in rats showed how Resveratrol can increase bone volume, bone trabecular number, and cortical thickness[15]. Furthermore, it has also been shown to promote bone growth and bone formation in mice in a Sirt-1 dependent manner[16]. A clinical study in 2020 even revealed how regular supplementation with 75 mg of Resveratrol twice daily, has potential to delay bone loss in the lumbar spine and femoral neck of postmenopausal women[17].

 

Effect on skin health

Woman with freckles

 

As we age, our natural collagen and elastin levels decrease. We begin to experience skin thinning which leads to wrinkles, sagginess, and age spots. Resveratrol can have a two-fold effect, both on neutralising free radicals and boosting antioxidant levels, so your skin can better defend and repair itself[18]. 

Is red wine really a good idea?

Current clinical trials reveal that Resveratrol is well tolerated and beneficially influences biomarkers in diseases such as neurological disorders, cardiovascular diseases, diabetes or obesity. It also holds potential for bone health, skin health, as well as in treating cancer. 

So yes, we want Resveratrol but to get 100 mg of Resveratrol, we will need to consume around 8-9 L of red wine daily. And come now folks, we all know how harmful too much alcohol can be. If you’re pregnant or have heart conditions, you should probably avoid alcohol altogether.

Resveratrol supplements

This is when longevity supplements come in handy. The synergetic effects of Resveratrol with other natural compounds has guided innovative product development like our Booster.

Avea's Booster and it's benefits

Our science-backed supplement contains 5 ingredients which have been carefully selected to target the diverse mechanisms of ageing at cellular level. We included 150 mg of Resveratrol in our Booster for its ability to also work with our NMN product. Taken together, these supplements work as a powerful duo to help in improving metabolic health and slowing down the ageing process. Dr. David Sinclair, well-renowned gerontologist, and New York Times best-selling author of ‘’Lifespan: Why we age and Why we don’t have to’’, takes Resveratrol supplements daily. 

 

Be part of this healthy ageing journey by joining us today!

 

References:

[1] Zhou DD, Luo M, Huang SY, Saimaiti A, Shang A, Gan RY, Li HB. Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases. Oxid Med Cell Longev. 2021 Jul 11;2021:9932218. doi: 10.1155/2021/9932218

 

[2] Man, A.W.C.; Li, H.; Xia, N. Resveratrol and the Interaction between Gut Microbiota and Arterial Remodelling. Nutrients 2020, 12, 119. https://doi.org/10.3390/nu12010119

 

[3] Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis. 2010;1(1):e10. doi: 10.1038/cddis.2009.8

 

[4] Das G, Shravage BV, Baehrecke EH. Regulation and function of autophagy during cell survival and cell death. Cold Spring Harb Perspect Biol. 2012 Jun 1;4(6):a008813. doi: 10.1101/cshperspect.a008813

 

[5] Morselli E., Maiuri M. C., Markaki M., et al. Caloric restriction and resveratrol promote longevity through the sirtuin-1-dependent induction of autophagy. Cell Death & Disease. 2010;1:p. 10. doi: 10.1038/cddis.2009.8

 

[6] Tissenbaum HA. Using C. elegans for ageing research. Invertebr Reprod Dev. 2015 Jan 30;59(sup1):59-63. doi: 10.1080/07924259.2014.940470. Epub 2014 Dec 9. PMID: 26136622; PMCID: PMC4464094

 

[7] Hou Y. J., Dan X. L., Babbar M., et al. Ageing as a risk factor for neurodegenerative disease. Nature Reviews. Neurology. 2019;15(10):565–581. doi: 10.1038/s41582-019-0244-7

 

[8] Baker D. J., Petersen R. C. Cellular senescence in brain ageing and neurodegenerative diseases: evidence and perspectives. The Journal of Clinical Investigation. 2018;128(4):1208–1216. doi: 10.1172/JCI95145

 

[9] Serino A., Salazar G. Protective role of polyphenols against vascular inflammation, ageing and cardiovascular disease. Nutrients. 2019;11:p. 23

 

[10] Fajemiroye J. O., da Cunha L. C., Saavedra-Rodriguez R., et al. Ageing-induced biological changes and cardiovascular diseases. BioMed Research International. 2018;2018:14. doi: 10.1155/2018/7156435.7156435

 

[11] Rajapakse A. G., Yepuri G., Carvas J. M., et al. Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in ageing: inhibition by resveratrol. PLoS One. 2011;6:p. 16.

 

[12] Leonardi G. C., Accardi G., Monastero R., Nicoletti F., Libra M. Ageing: from inflammation to cancer. Immunity & Ageing. 2018;15:p. 7. doi: 10.1186/s12979-017-0112-5

 

[13] Feng M., Zhong L. X., Zhan Z. Y., Huang Z. H., Xiong J. P. Resveratrol treatment inhibits proliferation of and induces apoptosis in human colon cancer cells. Medical Science Monitor. 2016;22:1101–1108. doi: 10.12659/MSM.897905

 

[14] Tou J. C. Resveratrol supplementation affects bone acquisition and osteoporosis: Pre- clinical evidence toward translational diet therapy. Biochimica et Biophysica Acta, Molecular Basis of Disease. 2015;1852(6):1186–1194. doi: 10.1016/j.bbadis.2014.10.003

 

[15] Tresguerres I. F., Tamimi F., Eimar H., et al. Resveratrol as anti-aging therapy for age-related bone loss. Rejuvenation Research. 2014;17(5):439–445. doi: 10.1089/rej.2014.1551

 

[16] Zhao M., Ko S.-Y., Garrett I. R., Mundy G. R., Gutierrez G. E., Edwards J. R. The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1-bone morphogenic protein 2 longevity axis. British Journal of Pharmacology. 2018;175(21):4183–4192. doi: 10.1111/bph.14477

 

[17] Wong RH, Thaung Zaw JJ, Xian CJ, Howe PR. Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. J Bone Miner Res. 2020 Nov;35(11):2121-2131. doi: 10.1002/jbmr.4115. Epub 2020 Jul 14. PMID: 32564438; PMCID: PMC7689937

 

[18] Farris P, Yatskayer M, Chen N, Krol Y, Oresajo C. Evaluation of Efficacy and Tolerance of a Nighttime Topical Antioxidant Containing Resveratrol, Baicalin, and Vitamin E for Treatment of Mild to Moderately Photodamaged Skin. J Drugs Dermatol. 2014;13(12):1467-1472

 

[19] Li J, Zhang CX, Liu YM, Chen KL, Chen G. A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction. Oncotarget. 2017 Aug 9;8(39):65717-65729. doi: 10.18632/oncotarget.20084. PMID: 29029466; PMCID: PMC5630366

 

[20] Berman, A.Y., Motechin, R.A., Wiesenfeld, M.Y. et al. The therapeutic potential of resveratrol: a review of clinical trials. npj Precision Onc 1, 35 (2017). https://doi.org/10.1038/s41698-017-0038-6

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