Our products are formulated with superior-quality, bioavailable ingredients that work together to target ageing on the cellular level and sustain your energy levels, vibrancy, and overall health.

NMN

What is NMN?

NMN, short for nicotinamide mononucleotide, is a naturally occurring vitamin B3 derivative. NMN is a precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme present in all human cells. NAD+ is essential for life and is linked closely to metabolism and ageing. 

Where can it be found in nature?

NMN is naturally present in our food, including milk, meat, avocado, broccoli, cabbage, cucumber, and edamame. However, it would be nearly impossible to get an efficient dose from food alone. You’d need to consume almost 100kg of broccoli or 416kg of beef just to get 250mg of NMN, the dose provided in our daily supplement.

What are its primary functions?

NMN becomes NAD+ in our bodies, and NAD+ is involved in hundreds of metabolic processes throughout the body. Its most crucial roles include helping turn nutrients into energy and working as a fuel for the enzymes involved in DNA protection and repair. Accumulating evidence suggests that NAD+ systemically declines with age and contributes to the development of age-related diseases. A 50-year-old, for example, has roughly half the levels of NAD+ as a 20-year-old. Of course, you can live with low levels of NAD+, but it will accelerate the ageing process and reduce your healthspan. Fortunately, increasing NAD+ levels has many health benefits for various organs, including the brain, cardiovascular system, and skin elasticity.

What are the benefits of taking NMN?

NMN targets the natural decline of NAD+ in our bodies as we age. By restoring NAD+ levels, NMN supplements help you regain, sustain, and maintain vibrant health and energy through the years. A number of studies have shown the beneficial effects of NMN on energy levels, memory, blood vessel health, metabolism, stem cell health, epigenome maintenance, and DNA damage repair. In a clinical study in 2014, for instance, a team of researchers led by Dr. David Sinclair, professor of genetics at Harvard Medical School and expert on biological ageing, demonstrated that NMN can extend lifespan, and a later study showed that NMN increases NAD+ levels and reverses DNA damage.

Why do we use NMN in our supplements?

NMN is one of the most promising supplements for slowing ageing. Since NMN gets converted into NAD+ in our cells, it can effectively replenish NAD+, helping you regain your health and energy to youthful levels. NMN is proven to be safe, stable, and effective. Continuous clinical trials demonstrate and unveil more of its benefits.

Sources

1. Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell metabolism, 27(3), 529–547. https://doi.org/10.1016/j.cmet.2018.02.011 
2. North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michan, S., Dai, J., Baker, D. J., Cen, Y., Wu, L. E., Sauve, A. A., van Deursen, J. M., Rosenzweig, A., & Sinclair, D. A. (2014). SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO journal, 33(13), 1438–1453. https://doi.org/10.15252/embj.201386907 
3. Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V., Aravind, L., Steegborn, C., & Sinclair, D. A. (2017). A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.), 355(6331), 1312–1317. https://doi.org/10.1126/science.aad8242 
4. Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., Csiszar, A., & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. GeroScience, 42(2), 527–546. https://doi.org/10.1007/s11357-020-00165-5
5. Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S. I., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science (New York, N.Y.), 372(6547), 1224–1229. https://doi.org/10.1126/science.abe9985 

Resveratrol

What is Resveratrol?

Resveratrol is a polyphenol produced by plants to act as a natural defence mechanism against environmental stressors. In humans, resveratrol has raised attention for being an effective antioxidant and for positively affecting the cells in the body, leading to a number of health benefits. Since its discovery, researchers have published more than 12,000 scientific papers about resveratrol, and over 200 human clinical trials involving this polyphenol have been conducted to date.

Where can it be found in nature?

Resveratrol can be found in Japanese knotweed and in a variety of foods, including peanuts, blueberries, and raspberries. It is also (somewhat famously) present in red wine as it gets concentrated from the skin of red grapes. It is produced in large quantities through microbial fermentation or extraction from Japanese knotweed for supplement use.

What are its primary functions and benefits?

In plants, resveratrol acts as a barrier against harsh environments. Scientific evidence suggests that it does the same for humans by working to protect the body’s cells and support healthy ageing. Published research and clinical data indicate that resveratrol supports bone health, cardiovascular health, blood glucose levels, healthy cognitive function, skin youthfulness, and oral health.

Resveratrol has also been shown to penetrate cells and help rejuvenate the mitochondria, again, helping to support healthy ageing. Mitochondria are the powerhouses that create energy inside every cell in our bodies. However, as we age, the mitochondrial function slowly impairs. This leads to the decline of many systems in our body as we get older, including cardiovascular, cognitive, skin, and bone systems. Resveratrol helps reverse or slow this process.

Part of the healthy ageing benefits of resveratrol can be explained by the activation of sirtuins, a family of enzymes that play a critical role in DNA repair. Resveratrol activates a specific sirtuin-coding gene called SIRT1 which results in gene expression and metabolic pathway activation, both of which are excellent for your energy levels and overall health.

Why do we use resveratrol in our supplements?

We have included resveratrol in our Booster for its ability to activate SIRT1. Ideally, this is taken in combination with our NMN product. NMN and resveratrol work synergistically to improve metabolic health and slow down the ageing process. NMN increases NAD+ levels and provides NAD+ to all seven sirtuins, while resveratrol provides additional SIRT1 activation to further mediate DNA repair. In addition, the activation of sirtuins by NAD+ regulates essential physiological processes, such as the circadian rhythm, glucose and fat metabolism, and normal ageing.

Another reason we’ve chosen resveratrol is that it is an apigenin bioenhancer, which is also present in our Booster. This lets the ingredients complement one another. Co-administration of apigenin and resveratrol allows more apigenin to survive liver metabolism, which results in more than twice the plasma apigenin levels (compared to using apigenin alone).

As an enzyme that breaks down our NAD+ levels, CD38 can accelerate ageing. Thankfully, apigenin can help prevent this NAD+ breakdown, so getting more apigenin into the body is invaluable in reducing the effects of CD38.

Sources

1. Ramírez-Garza, S. L., Laveriano-Santos, E. P., Marhuenda-Muñoz, M., Storniolo, C. E., Tresserra-Rimbau, A., Vallverdú-Queralt, A., & Lamuela-Raventós, R. M. (2018). Health Effects of Resveratrol: Results from Human Intervention Trials. Nutrients, 10(12), 1892. https://doi.org/10.3390/nu10121892
2. Thaung Zaw, J. J., Howe, P. R., & Wong, R. H. (2021). Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study. Clinical nutrition (Edinburgh, Scotland), 40(3), 820–829. https://doi.org/10.1016/j.clnu.2020.08.025
3. Moraes, D. S., Moreira, D. C., Andrade, J., & Santos, S. (2020). Sirtuins, brain and cognition: A review of resveratrol effects. IBRO reports, 9, 46–51. https://doi.org/10.1016/j.ibror.2020.06.004
4. Lee, J. A., Ha, S. K., Cho, E., & Choi, I. (2015). Resveratrol as a Bioenhancer to Improve Anti-Inflammatory Activities of Apigenin. Nutrients, 7(11), 9650–9661. https://doi.org/10.3390/nu7115485

Ubiquinol (CoQ10)

What is Ubiquinol (CoQ10)?

Ubiquinol is the active, bioavailable form of Coenzyme Q10 (CoQ10). CoQ10 is naturally present in the body (about 95% as Ubiquinol and 5% as Ubiquinone) and acts similarly to a vitamin in its biological functions. But, by definition, ubiquinol is not a vitamin since it can be synthesised by human cells. 

It is a powerful antioxidant and plays a major role in producing energy in cells. Research has revealed CoQ10’s wide range of health benefits. Unfortunately, concentrations decline as you age as well as through fatigue, strenuous exercise, smoking, illness, and even some medications. Thankfully, you can restore your CoQ10 levels with the help of dietary supplements.

Where can it be found in nature?

You can find CoQ10 in meats including, pork, beef, chicken, fatty fish, and organ meat, vegetables such as broccoli, cauliflower and spinach, fruits such as oranges and strawberries, as well as in legumes, sesame seeds, pistachios and peanuts. The CoQ10 you find in supplements is manufactured via a natural yeast fermentation process and is highly-effective.

What are its primary functions and benefits?

CoQ10 has an essential role in supplying all your cells with energy. It’s involved in making adenosine triphosphate (ATP), whose production happens within the mitochondria. To put it simply, CoQ10 acts as a fuel additive that optimizes mitochondrial performance, extracting the most energy with the least damage. Your mitochondria need to burn fuel cleanly and efficiently to assure their own integrity and your own longevity. Studies have shown that animals, from primitive worms to laboratory mice, enjoy dramatic extension of their life spans when supplemented with mitochondrial-protecting CoQ10, which suggests that it has important longevity benefits for humans, too.

Additional benefits from CoQ10's mitochondrial energy-boosting effects include protection from neurodegenerative diseases and mental health disorders, heart and vascular health support, enhanced lung function, healthy blood cholesterol levels and protection from the effects of elevated glucose in diabetes and metabolic syndrome. CoQ10 also has an important role as an antioxidant, protecting cell membranes from oxidative damage caused by free radicals.

Why do we use ubiquinol in our supplements?

We’ve included ubiquinol in our Booster supplement as it is the active, more bioavailable, antioxidant form of CoQ10—it’s ready for immediate use by the body. Ubiquinol is an ideal complement to our NMN product  (a potent NAD+ precursor) since ubiquinol works in synergy with NAD+ to support energy-production and mitochondrial health in every cell of your body. It’s important to note that your body doesn’t store CoQ10. Therefore, to see continued benefits, it's essential to keep up a supplement routine.

Sources

1. Yamamoto, Y., & Yamashita, S. (1997). Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress. Molecular aspects of medicine, 18 Suppl, S79–S84. https://doi.org/10.1016/s0098-2997(97)00007-1
2. Hernández-Camacho, Juan D et al. Coenzyme Q10 Supplementation in Aging and Disease. Frontiers in Physiology. 2018; 9(44) https://doi.org/10.3389/fphys.2018.00044
3. Castro-Marrero, J., Sáez-Francàs, N., Segundo, M. J., Calvo, N., Faro, M., Aliste, L., Fernández de Sevilla, T., & Alegre, J. (2016). Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial. Clinical nutrition (Edinburgh, Scotland), 35(4), 826–834. https://doi.org/10.1016/j.clnu.2015.07.010
4. Skarlovnik, A., Janić, M., Lunder, M., Turk, M., & Šabovič, M. (2014). Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. Medical science monitor : international medical journal of experimental and clinical research, 20, 2183–2188. https://doi.org/10.12659/MSM.890777