Studies have shown the benefits of NMN supplementation on energy levels, memory, blood vessel health, metabolism, stem cell health, epigenome maintenance, and DNA damage repair in animals. NMN has been shown to mitigate multiple aspects of ageing in older animals, improving their metabolism, stamina, and fertility, and increasing blood flow to the brain.
In 2014, a team of researchers led by Dr. David Sinclair, a professor of genetics at Harvard and a world-class expert on ageing, demonstrated that NMN can extend the lifespan of mice. In 2017, Sinclair's team increased NAD+ levels in mice which reversed age-related DNA damage. Finally, in 2021, the first randomised clinical trial showed that humans who took 250mg of NMN daily increased their NAD+ levels and improved muscle insulin sensitivity. Muscle insulin sensitivity is a critical component of whole-body insulin resistance and in protection from ageing-related disease, including type type 2 diabetes, heart disease, and certain cancers.
NMN is well absorbed when taken orally and is also much more stable in the digestive system and bloodstream and, therefore more bioavailable, than other NAD+ boosters. Recent studies suggest that NMN is the most potent NAD+ booster for targeting the signs of ageing. This may explain why many ageing scientists, including Sinclair, not only promote research on NMN, they take it for their own health and longevity.