NMN SCIENCE
WHAT IS NMN?
NMN is a potent NAD+ precursor.
NMN, short for nicotinamide mononucleotide, is a naturally occurring vitamin B3 derivative and a building block, known as a precursor, of NAD+ (nicotinamide adenine dinucleotide). NAD+ is an essential coenzyme present in all living cells that plays a role in protecting us from the effects of ageing and disease. But, unfortunately, NAD+ declines as we age.
That’s where NMN comes in. By targeting the natural decline of NAD+ in our bodies, NMN replenishes NAD+ levels and helps you maintain vibrant health for longer.
At Avea, our NMN supplement is a powerful high-quality formulation that targets the diverse mechanisms of ageing at the cellular level. Our supplement is third-party tested for purity and contains Uthever® NMN, a brand recognized for its top quality and safety, as well as less temperature sensitivity and more bioavailability than other NMN brands.
Our NMN supplement has shown promising results in a recent randomised, double-blind, controlled clinical trial to evaluate its efficacy and safety.
The Science Behind NMN
NMN
What is it: A naturally occurring vitamin B3 derivative and a precursor of NAD+, an essential coenzyme present in all living cells that is closely linked to metabolism and ageing.
What it does: Targets the natural decline of NAD+ in our bodies as we age. By restoring NAD+ levels, NMN helps you regain and maintain vibrant health and energy.
What is NMN?
NMN, short for nicotinamide mononucleotide, is a naturally occurring vitamin B3 derivative. NMN is a precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme present in all human cells. NAD+ is essential for life and is linked closely to metabolism and ageing.
Where can it be found in nature?
NMN is naturally present in our food, including milk, meat, avocado, broccoli, cabbage, cucumber, and edamame. However, it would be nearly impossible to get an efficient dose from food alone. You’d need to consume almost 100kg of broccoli or 416kg of beef just to get 250mg of NMN, the dose provided in our daily supplement.
What are its primary functions?
NMN becomes NAD+ in our bodies, and NAD+ is involved in hundreds of metabolic processes throughout the body. Its most crucial roles include helping turn nutrients into energy and working as a fuel for the enzymes involved in DNA protection and repair. Accumulating evidence suggests that NAD+ systemically declines with age and contributes to the development of age-related diseases. A 50-year-old, for example, has roughly half the levels of NAD+ as a 20-year-old. Of course, you can live with low levels of NAD+, but it will accelerate the ageing process and reduce your healthspan. Fortunately, increasing NAD+ levels has many health benefits for various organs, including the brain, cardiovascular system, and skin elasticity.
What are the benefits of taking NMN?
NMN targets the natural decline of NAD+ in our bodies as we age. By restoring NAD+ levels, NMN supplements help you regain, sustain, and maintain vibrant health and energy through the years. A number of studies have shown the beneficial effects of NMN on energy levels, memory, blood vessel health, metabolism, stem cell health, epigenome maintenance, and DNA damage repair. In a clinical study in 2014, for instance, a team of researchers led by Dr. David Sinclair, professor of genetics at Harvard Medical School and expert on biological ageing, demonstrated that NMN can extend lifespan, and a later study showed that NMN increases NAD+ levels and reverses DNA damage.
Why do we use NMN in our supplements?
NMN is one of the most promising supplements for slowing ageing. Since NMN gets converted into NAD+ in our cells, it can effectively replenish NAD+, helping you regain your health and energy to youthful levels. NMN is proven to be safe, stable, and effective. Continuous clinical trials demonstrate and unveil more of its benefits.
Sources
- Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell metabolism, 27(3), 529–547. https://doi.org/10.1016/j.cmet.2018.02.011
- North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michan, S., Dai, J., Baker, D. J., Cen, Y., Wu, L. E., Sauve, A. A., van Deursen, J. M., Rosenzweig, A., & Sinclair, D. A. (2014). SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO journal, 33(13), 1438–1453. https://doi.org/10.15252/embj.201386907
- Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V., Aravind, L., Steegborn, C., & Sinclair, D. A. (2017). A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.), 355(6331), 1312–1317. https://doi.org/10.1126/science.aad8242
- Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., Csiszar, A., & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. GeroScience, 42(2), 527–546. https://doi.org/10.1007/s11357-020-00165-5
- Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S. I., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science (New York, N.Y.), 372(6547), 1224–1229. https://doi.org/10.1126/science.abe9985
NMN AND NAD+ LONGEVITY
NMN replenishes NAD+ and counteracts the effects of ageing.
NMN AND SCIENTIFIC STUDIES
NMN supplementation effectively targets the signs of ageing.
You can think of NAD+ as a type of fuel that helps many proteins and enzymes in your body carry out essential functions. NNM is a building block of this "fuel," meaning it is needed in order for your body to make NAD+.
NMN
Regain your health, energy, and cellular functions to youthful levels.
Backed by science, NMN is safe and effective at slowing and even reversing ageing, increasing energy, and supporting nearly every organ in the body. Use it on its own or in tandem with the Booster for optimal results.
References
- Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell metabolism, 27(3), 529–547. https://doi.org/10.1016/j.cmet.2018.02.011
- North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michan, S., Dai, J., Baker, D. J., Cen, Y., Wu, L. E., Sauve, A. A., van Deursen, J. M., Rosenzweig, A., & Sinclair, D. A. (2014). SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO journal, 33(13), 1438–1453. https://doi.org/10.15252/embj.201386907
- Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V., Aravind, L., Steegborn, C., & Sinclair, D. A. (2017). A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.), 355(6331), 1312–1317. https://doi.org/10.1126/science.aad8242
- Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., Csiszar, A., & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. GeroScience, 42(2), 527–546. https://doi.org/10.1007/s11357-020-00165-5
- Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S. I., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science (New York, N.Y.), 372(6547), 1224–1229. https://doi.org/10.1126/science.abe9985