Boost your NAD+ for a whole year with Avea.
Here’s what you might expect, according to the science.
SPOILER: ELEVATED NAD+ LEVELS ARE A GOOD THING.
With our NMN supplement, you can expect to unlock evidence-based benefits from your cells to whole body systems: increased NAD+, healthy mitochondria, muscle benefits, and more.
Double-tested in Switzerland for 99% purity
Replenishes your NAD+ - a coenzyme that declines with ageing
Synergistic effect together with the Booster
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Benefits you can expect after:
1 Hour: NMN Enters Your Cells
NMN acts quickly, according to the research. Preclinical studies in mice on the pharmacokinetics of NMN suggest that it’s absorbed from the gut into blood circulation within minutes and transported into tissues between 10 and 30 minutes [1, 2]. That’s when the magic (or biochemistry) happens. The NMN is immediately utilized for NAD+ biosynthesis. Research suggests that fast uptake is made possible by an NMN-specific transporter called Slc12a8. A study published in Nature Metabolism identified the transporter, which is especially concentrated in the small intestine in mice [3].
5 Hours: NAD+ Is on the Rise
Same day, more activity in your cells. Studies in humans show increased levels of NAD+ metabolites in blood plasma within the first few hours of NMN supplementation—and they continue to rise steadily, suggesting increased utilization of NAD+ in cells and tissues [4]. Your cells are already taking advantage of increased NAD+ levels to support hundreds of critical cellular processes. If you listen closely, you may hear them say, “thank you.”
Day 3: Happy Mitochondria
Your NAD+ levels continue to rise, now benefiting your cell’s powerhouses and the place where your cellular energy is made: the mitochondria. A preclinical study demonstrated that treatment of human kidney cells in culture with NMN for three days resulted in increased mitochondrial replication [5].
Scroll down to continue reading through benefits up to 6 weeks ⬇️
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Benefits of daily NMN use:
Makes you feel rested and energised
By replenishing your body’s NAD+ levels, NMN promotes your energy metabolism and more youthful energy levels.
Mimics calorie restriction
Long-term NMN supplementation suppresses age-associated weight gain.
Replenishes NAD+ level
Converts nutrients from your food into energy. Helps to maintain your DNA health and regulates the function of your cells.
Enhances fitness performance
Increasing NAD+ levels improves metabolic function and can increase energy levels for maximal fitness performance.
Supports DNA repair
Maintains the health of your genome to help improve reproductive health and protect against genetic mutations and ageing-related diseases.
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6 Weeks: Muscle Benefits
We’re moving from cells to systems as aspects of your fitness may be improving. A human clinical study published in Nature Aging demonstrated NAD+ was one of the most depleted metabolites in aging muscle and that high levels of NAD+ were associated with healthy muscle function [8]. Another clinical study found that oral supplementation of NMN at a dose of 250 mg per day for 6 weeks partly improved muscle strength and performance in healthy older men [9].
8 Weeks: Surface-Level Benefits
How’s your skin looking? Advanced glycation end products, or AGEs, are markers of skin aging. A small clinical trial involving healthy postmenopausal women found that NMN supplementation for eight weeks at 300 mg of NMN per day resulted in decreased AGEs in the skin [10].
10 Weeks: Healthy Insulin Sensitivity
There may be more happening in your muscles at 10 weeks. One clinical study of prediabetic women made two important discoveries. The first was an increase in NMN metabolites in skeletal muscle tissue, suggesting that the muscles were using more NAD+. The second finding suggested that NMN may support healthy insulin sensitivity in skeletal muscle and helps regulate the expression of genes related to muscle remodeling—the turnover of muscle proteins, organelles, and cell populations. Participants in the trial were supplemented with 250 mg of NMN per day [11].
3 Months: Faster Walking and Longer Telomeres
It’s been three months and you’ve logged 60 days of 40% higher levels of NAD+ in your cells and tissues. What do you have to show for it? A lot, according to clinical studies. One trial found an improvement in gait speed (translation: walking speed) in healthy, elderly men who took 250 mg of NMN per day [9]. The other found that telomere length had doubled in peripheral blood mononuclear cells at a dose of 300 mg of NMN per day [12].
1 Year: Healthy Aging and NAD+ Go Hand-In-Hand
Congratulations on your first year of replenishing the NAD+ lost to aging. NAD+ declines by as much as 50% every 20 years, according to research. It’s important to keep up your Avea routine: Research shows that four weeks after discontinuation of NMN, NAD+ levels returned to pre-supplementation levels [7]. Just like with exercise, sleep, and diet—consistency is key for long-term results. Human studies are beginning to show that healthy aging and NAD+ abundance go hand-in-hand [8].
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[1] Yoshino, J., et al., Cell Metab. 14: 528–536 (2011).
[2] Mills, K. F. et al. Cell Metab. 24: 795–806 (2016).
[3] Grozio, A., et al., Nature Metabolism 1: 47-57 (2019).
[4] Irie, J., et al., Endocrine Journal 67 (2): 153-160 (2020).
[5] Nomiyama, T., et al., The Journal of Biochemistry 171 (3): 325-338 (2021).
[6] Fu, J., et al., J Biol Chem. 287 (29): 24460–24472 (2012).
[7] Okabe, K., et al., Frontiers in Nutrition 9: 868640 (2022).
[8] Janssens, G.E. et al., Nat Aging 2: 254–263 (2022).
[9] Igarashi, M. et al., NPG Aging 8: 5 (2022).
[10] Morita, Y. et al., Glycative Stress Research 9 (2): 33-41 (2022).
[11] Yoshino, M. et al., Science 372 (6547): 1224-1229 (2021).
[12] Niu, K-M. et al., Frontiers in Nutrition 8: 756243 (2021).