Top 5 senolytic supplements to remove senescent cells

Feeling tired, stiff, or struggling with brain fog?

Your body may be weighed down by senescent cells, also known as "zombie" cells. These are damaged cells that no longer function properly but refuse to die. Over time, they accumulate and trigger inflammation, fatigue, and accelerated ageing.

While your body naturally clears these cells through autophagy and immune surveillance, this process slows down with age.

A modern lifestyle—characterised by stress, poor sleep, processed foods, and environmental toxins—further accelerates the build-up of these senescent cells, making it harder for your body to keep up.

The good news? Research suggests that senolytic supplements can help remove aged, dysfunctional cells, thereby reducing inflammation and boosting cellular renewal and overall health.

But with so many supplements on the market, which senolytics actually work?

Avea has done the research for you. Here’s a breakdown of the top 5 science-backed senolytic supplements—so you can invest in your health with confidence.

Do senolytic supplements actually work?

Senolytics have shown significant promise in extending health span, with both preclinical and clinical studies supporting their benefits.

Research in mice has demonstrated that senolytic compounds can enhance physical function, extend lifespan, and lower mortality risk. These senolytics work by eliminating senescent cells and also preventing them from releasing harmful inflammatory signals that damage surrounding tissues.

Early human trials are also yielding encouraging results, showing reductions in senescent cells and improvements in physical performance.

With the growing popularity of senolytic supplements, choosing the right ones can be challenging. The key is to focus on quality, sourcing, formulation, and dosage. Since over-the-counter senolytics are not regulated, purity, efficacy, and safety can vary widely.

Let’s explore the top 5 science-backed senolytics—compounds known for their proven benefits, minimal to no side effects, and endorsement from longevity experts like Dr David Sinclair and Dr. Andrew Huberman.

5 senolytic supplements to reverse ageing

1. Fisetin

Fisetin is a natural flavonoid found in strawberries, apples, persimmons, and onions—but in amounts too small to provide its full benefits, making supplementation essential.

Unlike most antioxidants, Fisetin actively eliminates senescent cells—the ‘zombie’ cells that accelerate ageing and inflammation. This makes it one of the most potent senolytics known.

Key benefits of Fisetin

Reduces inflammation by blocking pathways that trigger inflammatory responses.
Supports brain health by activating proteins that protect brain cells.
Clears senescent cells, slowing ageing and reducing the risk of age-related diseases.
May help prevent cancer growth by inhibiting tumour-promoting pathways.

Discover more about Fisetin supplements

2. Quercetin

Quercetin is another natural flavonoid found in citrus fruits, apples, onions, broccoli, and olive oil. Used for centuries in plant-based medicine, it’s gaining recognition for its antioxidant, anti-inflammatory, and senolytic properties.

As a potent antioxidant, Quercetin helps neutralise free radicals, preventing oxidative stress—a key driver of ageing and chronic diseases. It also supports heart health, with studies showing it helps lower blood pressure and improves arterial function.

Quercetin’s neuroprotective effects make it valuable for brain health, as it promotes the growth of new neurons and reduces neuroinflammation, potentially lowering the risk of Alzheimer’s and Parkinson’s disease.

However, due to poor bioavailability, it’s best taken in enhanced formulations or when combined with Fisetin to maximise its longevity benefits.

Cell Primer: The science-based senolytic supplement

To reduce the burden of zombie cells on your health, a multi-target approach is needed. The best senolytic supplement should be able to:

Reduce new senescent cell formation.
Eliminate and clear out old senescent cells and their debris.
Block inflammatory pathways that fuel further senescence.

Thorough research led to the development of the Avea Cell Primer – a revolutionary senolytic supplement that targets senescent cell clearance from various angles.

Our blend of ingredients includes well-researched senolytics Quercetin and Fisetin, together with potent antioxidants Spermidine, Ergothioneine, PQQ, and Selenium–all in clinically relevant dosages, proven to deliver results.

The Cell Primer takes a synergistic approach to reducing cellular senescence—it removes zombie cells, reduces oxidative stress, boosts mitochondrial function, and optimises cellular renewal for long-term health and longevity.

How the Cell Primer supplement helps in getting rid of zombie cells

Here’s a breakdown of how each ingredient in the Cell Primer optimises senescent cell removal:

Quercetin and Fisetin
These potent senolytics induce apoptosis (programmed cell death) in senescent cells, preventing them from spreading inflammatory signals that accelerate ageing. They also suppress inflammatory pathways, reducing the formation of new senescent cells.
Spermidine
Once senescent cells undergo apoptosis, Spermidine enhances autophagy, your body's built-in clean-up system. This helps efficiently clear out cellular debris, preventing toxic accumulation and supporting tissue regeneration.
Ergothioneine
This powerful antioxidant that neutralises reactive oxygen species (ROS), protecting mitochondria from oxidative stress—one of the biggest drivers of cellular ageing and dysfunction.
Selenium
Supports glutathione peroxidase, a key enzyme in detoxifying oxidative stress. It also helps in immune-mediated clearance of senescent cells, ensuring the body efficiently eliminates harmful cellular build-up.
PQQ
Stimulates new mitochondrial formation, enhancing cellular energy production while reducing inflammation and oxidative stress, key factors in ageing and longevity.

Benefits you can feel from the Cell Primer

Consistent use of the Cell Primer will lead to:

Less inflammation
Stronger immune system
Sustained energy levels\
Boosted metabolism

New senescent cells form every day as part of the ageing process. That’s why continuous use of Cell Primer is essential to keep your body in a state of ongoing cellular renewal and protection.

With the Cell Primer, you get highly concentrated doses of key longevity compounds—far beyond what you'd get from food alone.

Besides, each batch is independently tested in a Swiss lab to ensure purity and safety, and it’s produced under GMP-certified standards for quality you can trust.

While senolytics actively eliminate senescent “zombie” cells, senomorphics, on the other hand, modulate and suppress the harmful effects of senescent cells without killing them, helping to reduce inflammation and support cellular function.

3. EGCG

EGCG (Epigallocatechin Gallate) is a green tea extract. As a powerful antioxidant and anti-inflammatory, EGCG supplements may help protect against age-related cellular damage.

Studies show EGCG suppresses senescence-associated β-galactosidase (SA-β-Gal), a biomarker of ageing, and inhibits inflammatory pathways like IL-6 and TNF-α, reducing chronic inflammation.

Additionally, it enhances autophagy, the body's natural cell renewal process, supporting mitochondrial function and energy production.

Supplementing with EGCG ensures consistent, therapeutic levels, making it a convenient option for those looking to support longevity, cellular repair, and overall health.

4. Curcumin

Curcumin, the active polyphenol in turmeric, is widely known for its anti-inflammatory and antioxidant properties.

While not a senolytic, it acts as a senomorphic. Research shows curcumin reduces SASP (Senescence-Associated Secretory Phenotype) by suppressing inflammatory cytokines like IL-6 and IL-8, which contribute to chronic inflammation. It also activates longevity pathways by influencing sirtuins and AMPK, key regulators of cellular metabolism and energy balance.

Curcumin also enhances autophagy, promoting the removal of damaged cellular components, while inhibiting NF-κB, a major driver of inflammation. It also supports gut microbiome health, which plays a crucial role in immune function and metabolic stability.

Despite these benefits, curcumin has low bioavailability, so supplementation with enhanced formulations (such as the Avea Mobiliser) is essential for better absorption and sustained effects.

5. Apigenin

Apigenin, a natural flavonoid found in parsley, chamomile, and celery, is known for its anti-inflammatory, antioxidant, and longevity-supporting properties. As a senomorphic, it helps modulate the effects of senescent cells without eliminating them.

Research shows Apigenin inhibits SASP (Senescence-Associated Secretory Phenotype), reducing the harmful inflammatory secretions from senescent cells that contribute to tissue damage and ageing.

It also protects DNA from oxidative stress, preventing cellular damage that accelerates ageing and disease. Additionally, Apigenin enhances cellular detoxification, helping the body clear out toxins and maintain cellular function. By reducing inflammation and oxidative stress while supporting cellular repair, Apigenin plays a key role in healthy ageing and long-term vitality.