MenoSpan

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4.7/5 37 reviews

MenoSpan

MenoSpan is a daily supplement for perimenopause and menopause, designed to help you feel like yourself again.

As you enter perimenopause, levels of oestrogen and progesterone begin to fluctuate and decline. This can affect your mood, mental clarity and everyday energy.

Many menopause supplements focus on individual symptoms such as hot flushes or require multiple products to support different needs. MenoSpan brings mood, mental clarity and everyday energy support together in one daily, hormone-free formula with clinically studied, naturally derived ingredients. Its formula:

  • Supports a positive mood
  • Promotes mental clarity
  • Helps reduce tiredness and fatigue
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Made in Europe

Made in Europe

Based on cutting-edge research

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90 days money-back guarantee

Feel your best through perimenopause and menopause.

During perimenopause, changing levels of oestrogen and progesterone can affect many of the processes involved in how you feel and function every day. As those signals fluctuate during perimenopause, many women notice changes they may not have expected: irritability without an obvious cause, difficulty concentrating later in the day, trouble finding the right word, and a tiredness and fatigue which becomes more noticeable throughout the day.

MenoSpan combines four clinically studied ingredients to support a positive mood, mental clarity and everyday energy without acting directly on hormone levels.

Positive mood Mental clarity

The hormone oestrogen plays an important role in regulating mood, including through serotonin and dopamine. As oestrogen fluctuates during perimenopause, mood can become harder to regulate and many women struggle with irritability and anxiousness. MenoSpan combines Affron®, an extract derived from the saffron flower (Crocus sativus), with Vitamin B6 to support a positive mood. Affron® saffron extract helps maintain steady levels of key mood-regulating neurotransmitters like serotonin and dopamine, which naturally drop as estrogen declines during menopause. By balancing these brain chemicals, it effectively helps to smooth out mood swings, ease nervous tension, and promote a steady sense of daily calm. Vitamin B6 is involved in the production of neurotransmitters including serotonin, dopamine and GABA - important chemical messengers involved in mood. In a recent clinical study, supplementation with Affron® saffron extract led to a decrease in low mood scores by 53% after 12 weeks in 202 participants.

The hormone oestrogen plays an important role in regulating mood, including through serotonin and dopamine. As oestrogen fluctuates during perimenopause, mood can become harder to regulate and many women struggle with irritability and anxiousness. MenoSpan combines Affron®, an extract derived from the saffron flower (Crocus sativus), with Vitamin B6 to support a positive mood. Affron® saffron extract helps maintain steady levels of key mood-regulating neurotransmitters like serotonin and dopamine, which naturally drop as estrogen declines during menopause. By balancing these brain chemicals, it effectively helps to smooth out mood swings, ease nervous tension, and promote a steady sense of daily calm. Vitamin B6 is involved in the production of neurotransmitters including serotonin, dopamine and GABA - important chemical messengers involved in mood. In a recent clinical study, supplementation with Affron® saffron extract led to a decrease in low mood scores by 53% after 12 weeks in 202 participants.

Hormonal fluctuations during perimenopause, the resulting increase in stress can make it harder to concentrate and think clearly throughout the day. MenoSpan contains Rhodiolife®, an extract from the root of Rhodiola rosea, a flowering plant traditionally used during periods of stress. It is standardised to 3% rosavins and 1% salidroside, two of the naturally occurring compounds found in Rhodiola root, ensuring a consistent concentration in every dose. Clinical studies on Rhodiola rosea have shown reductions in mental fatigue and improvements in mental performance under stress, helping you maintain concentration and think clearly throughout the day.

  • Positive mood
    The hormone oestrogen plays an important role in regulating mood, including through serotonin and dopamine. As oestrogen fluctuates during perimenopause, mood can become harder to regulate and many women struggle with irritability and anxiousness. MenoSpan combines Affron®, an extract derived from the saffron flower (Crocus sativus), with Vitamin B6 to support a positive mood. Affron® saffron extract helps maintain steady levels of key mood-regulating neurotransmitters like serotonin and dopamine, which naturally drop as estrogen declines during menopause. By balancing these brain chemicals, it effectively helps to smooth out mood swings, ease nervous tension, and promote a steady sense of daily calm. Vitamin B6 is involved in the production of neurotransmitters including serotonin, dopamine and GABA - important chemical messengers involved in mood. In a recent clinical study, supplementation with Affron® saffron extract led to a decrease in low mood scores by 53% after 12 weeks in 202 participants.
  • Mental clarity
    Hormonal fluctuations during perimenopause, the resulting increase in stress can make it harder to concentrate and think clearly throughout the day. MenoSpan contains Rhodiolife®, an extract from the root of Rhodiola rosea, a flowering plant traditionally used during periods of stress. It is standardised to 3% rosavins and 1% salidroside, two of the naturally occurring compounds found in Rhodiola root, ensuring a consistent concentration in every dose. Clinical studies on Rhodiola rosea have shown reductions in mental fatigue and improvements in mental performance under stress, helping you maintain concentration and think clearly throughout the day.
  • Everyday energy
    As the body's hormonal balance is upset during perimenopause, changes in sleep and other menopause symptoms can make tiredness and fatigue more noticeable throughout the day. MenoSpan contains a branded botanical blend of Bergamot, Lemon Balm & Peony, developed specifically for menopause. In clinical studies in menopausal women, this blend significantly improved physical and mental fatigue compared with placebo.
  • Hormone-free daily support
    Many menopause solutions can interfere with hormones, and for some women, this can make symptoms worse. While a hormonal approach can be effective for some women, not every woman wants, needs or is suited to them. MenoSpan offers a natural, hormone-free option, combining clinically studied plant extracts of saffron, rhodiola, bergamot, lemon balm and peony with Vitamin B6 to support three areas commonly affected during perimenopause and menopause: mood, mental clarity and fatigue, without replacing or mimicking hormones.
Everyday energy Hormone-free daily support

As the body's hormonal balance is upset during perimenopause, changes in sleep and other menopause symptoms can make tiredness and fatigue more noticeable throughout the day. MenoSpan contains a branded botanical blend of Bergamot, Lemon Balm & Peony, developed specifically for menopause. In clinical studies in menopausal women, this blend significantly improved physical and mental fatigue compared with placebo.

As the body's hormonal balance is upset during perimenopause, changes in sleep and other menopause symptoms can make tiredness and fatigue more noticeable throughout the day. MenoSpan contains a branded botanical blend of Bergamot, Lemon Balm & Peony, developed specifically for menopause. In clinical studies in menopausal women, this blend significantly improved physical and mental fatigue compared with placebo.

Many menopause solutions can interfere with hormones, and for some women, this can make symptoms worse. While a hormonal approach can be effective for some women, not every woman wants, needs or is suited to them. MenoSpan offers a natural, hormone-free option, combining clinically studied plant extracts of saffron, rhodiola, bergamot, lemon balm and peony with Vitamin B6 to support three areas commonly affected during perimenopause and menopause: mood, mental clarity and fatigue, without replacing or mimicking hormones.

Positive mood

The hormone oestrogen plays an important role in regulating mood, including through serotonin and dopamine. As oestrogen fluctuates during perimenopause, mood can become harder to regulate and many women struggle with irritability and anxiousness. MenoSpan combines Affron®, an extract derived from the saffron flower (Crocus sativus), with Vitamin B6 to support a positive mood. Affron® saffron extract helps maintain steady levels of key mood-regulating neurotransmitters like serotonin and dopamine, which naturally drop as estrogen declines during menopause. By balancing these brain chemicals, it effectively helps to smooth out mood swings, ease nervous tension, and promote a steady sense of daily calm. Vitamin B6 is involved in the production of neurotransmitters including serotonin, dopamine and GABA - important chemical messengers involved in mood. In a recent clinical study, supplementation with Affron® saffron extract led to a decrease in low mood scores by 53% after 12 weeks in 202 participants.

Mental clarity

Hormonal fluctuations during perimenopause, the resulting increase in stress can make it harder to concentrate and think clearly throughout the day. MenoSpan contains Rhodiolife®, an extract from the root of Rhodiola rosea, a flowering plant traditionally used during periods of stress. It is standardised to 3% rosavins and 1% salidroside, two of the naturally occurring compounds found in Rhodiola root, ensuring a consistent concentration in every dose. Clinical studies on Rhodiola rosea have shown reductions in mental fatigue and improvements in mental performance under stress, helping you maintain concentration and think clearly throughout the day.

Everyday energy

As the body's hormonal balance is upset during perimenopause, changes in sleep and other menopause symptoms can make tiredness and fatigue more noticeable throughout the day. MenoSpan contains a branded botanical blend of Bergamot, Lemon Balm & Peony, developed specifically for menopause. In clinical studies in menopausal women, this blend significantly improved physical and mental fatigue compared with placebo.

Hormone-free daily support

Many menopause solutions can interfere with hormones, and for some women, this can make symptoms worse. While a hormonal approach can be effective for some women, not every woman wants, needs or is suited to them. MenoSpan offers a natural, hormone-free option, combining clinically studied plant extracts of saffron, rhodiola, bergamot, lemon balm and peony with Vitamin B6 to support three areas commonly affected during perimenopause and menopause: mood, mental clarity and fatigue, without replacing or mimicking hormones.

Clean, transparent, scientifically-backed ingredients.

Formulated with traceable, clinically studied ingredients. Formulations developed and processed in Switzerland.

Full supplement facts

Saffron Extract (Affron®)

(28 mg)

Saffron is a natural botanical derived from the Crocus sativus flower and studied for its role in supporting mood. MenoSpan contains Affron®, a clinically studied saffron extract standardised to 3.5% Lepticrosalides® for a consistent concentration of its key active compounds. 

Affron® has also been specifically studied in perimenopausal women. In a 12-week randomised, placebo-controlled study of 86 women, the same 28 mg daily dose found in MenoSpan improved mood and psychological wellbeing compared with placebo.

Rhodiola Rosea Extract (Rhodiolife®)

(100 mg)

Rhodiola rosea is a flowering plant traditionally used during periods of stress, with its root studied for its effects on mental fatigue and performance under stress. MenoSpan contains Rhodiolife®, a Rhodiola rosea root extract standardised to 3% rosavins and 1% salidroside, providing a consistent concentration of its key compounds in every daily dose.

Clinical research on Rhodiola rosea has shown reductions in mental fatigue and improvements in mental performance under stress, helping support concentration and clearer thinking throughout the day.

Bergamot, Lemon Balm & Peony Blend

(475 mg)

This is a patented blend of bergamot fruit, lemon balm leaves and peony root, developed specifically to support women through menopause. MenoSpan contains 475 mg of this blend, the clinically studied dose, to help reduce the tiredness and fatigue that can make it harder to maintain your usual energy throughout the day.

In two double-blind, randomised, placebo-controlled studies involving more than 300 pre- and menopausal women, this branded blend of  bergamot, lemon balm and peony significantly improved physical and mental fatigue from the second month compared with placebo.

Vitamin B6 (as P5P)

(1.4 mg)

Vitamin B6 is an essential nutrient involved in the production of neurotransmitters such as serotonin, dopamine and GABA, which play an important role in mood and nervous system function. It also contributes to the regulation of hormonal activity and helps reduce tiredness and fatigue.

MenoSpan provides 1.4 mg of Vitamin B6 - 100% of the daily reference intake - in the form of P5P (pyridoxal-5-phosphate), its active coenzyme form. Together, these roles make Vitamin B6 an important part of MenoSpan’s support for mood and everyday energy throughout menopause.

Full supplement facts

Full supplement facts

Supplement Facts

MenoSpan

Includes 60 capsules per bottle (1-month supply)
MenoSpan
MenoSpan
MenoSpan
MenoSpan
MenoSpan
MenoSpan
4.6/5 (600+ reviews)

MenoSpan

Includes 60 capsules per bottle (1-month supply)

MenoSpan is a daily, hormone-free supplement designed to support mood, mental clarity and everyday energy throughout perimenopause and menopause, helping you feel more like yourself as your hormones change.

Many menopause supplements focus on individual symptoms or require several products to support different areas. MenoSpan brings broader menopause support into one daily formula, combining clinically studied, naturally derived ingredients, without replacing or mimicking hormones.

Its formula supports four key areas:

  • For mood: Affron® Saffron Extract (28 mg) + Vitamin B6 (1.4 mg). Affron® supports a positive mood and helps maintain levels of key mood-regulating neurotransmitters such as serotonin and dopamine, while Vitamin B6 is involved in the production of serotonin, dopamine and GABA.

  • For mental clarity: Rhodiolife® Rhodiola Extract (100 mg) helps reduce mental fatigue and support performance during periods of stress, helping you maintain concentration and think clearly throughout the day.

  • For everyday energy:  A branded blend of bergamot, lemon balm and peony (475 mg), developed specifically for menopause, helps reduce the tiredness and fatigue that can make it harder to maintain your usual energy throughout the day. Vitamin B6 also contributes to the reduction of tiredness and fatigue.

  • Hormone-free: Many menopause solutions can interfere with hormones, and for some women, this can make symptoms worse. While these approaches can also still be effective for many women, not every woman wants, needs or is suited to them. MenoSpan instead uses clinically studied botanical extracts and Vitamin B6 to support common changes experienced through menopause without replacing or mimicking hormones.

2-month supply delivered every 2 months

Pause or cancel at any time

1-month supply delivered monthly

Pause or cancel at any time

3-month supply, delivered every 3 months. Pause or cancel at any time.

Free welcome kit (worth £77.70) with first order

Limited time only. Free welcome kit includes:

Magnesium Complex

Magnesium Complex

Compact Pill Pod

Compact Pill Pod

Premium Pill Organiser

Premium Pill Organiser

5x Collagen Activator Sachets

5x Collagen Activator Sachets

5x Essentials Sachets

5x Essentials Sachets

3-month supply, delivered every 3 months – one annual invoice. Pause or cancel at any time.

Free welcome kit (worth £77.70) with first order

Limited time only. Free welcome kit includes:

Magnesium Complex

Magnesium Complex

Compact Pill Pod

Compact Pill Pod

Premium Pill Organiser

Premium Pill Organiser

5x Collagen Activator Sachets

5x Collagen Activator Sachets

5x Essentials Sachets

5x Essentials Sachets

3-month supply, delivered every 3 months. Pause or cancel at any time.

Free welcome kit (worth £77.70) with first order

Limited time only. Free welcome kit includes:

Magnesium Complex

Magnesium Complex

Compact Pill Pod

Compact Pill Pod

Premium Pill Organiser

Premium Pill Organiser

5x Collagen Activator Sachets

5x Collagen Activator Sachets

5x Essentials Sachets

5x Essentials Sachets

1-month supply delivered monthly

Pause or cancel at any time

Buy one time for £55.00
90 days money-back guarantee Tooltip icon

Women, take 2 capsules daily in the morning before breakfast with a glass of water. Do not exceed recommended daily intake.

Made in Europe
Formulated by Experts
Sustainable Packaging
Clinically proven results
Vegan
Halal

Active ingredients:

Blend of Bergamot Fruit Extract, Lemon balm Leaves Extract and Peony Roots 475 mg, Rhodiola Rosea Root Extract (Rhodiolife®) 100 mg, Saffron Stigmas Extract (Affron®) 28 mg, Vitamin B6 (from Pyridoxal 5-Phosphate) 1.4 mg

Other ingredients:

  • Hydroxypropyl Methylcellulose (Glazing Agent): Forms the capsule shell — a plant-based alternative to gelatin, making the product suitable for vegans.
  • Calcium Phosphate and Magnesium Salts of Fatty Acids (Anti-Caking Agents): Prevent the powder from clumping during manufacturing, ensuring consistent fill weight and quality in every capsule.
  • Microcrystalline Cellulose (Bulking Agent): Adds the necessary volume to fill the capsule properly, allowing the active ingredients to be encapsulated at the right dose.

Worldwide shipping, free shipping on orders over £50/€50/CHF50, 3-5 day average delivery time.

MenoSpan

Support mood, mental clarity and everyday energy throughout perimenopause and menopause
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What actually happens during perimenopause and menopause?

Menopause basics

Perimenopause is the transition leading up to menopause, when levels of hormones such as oestrogen and progesterone begin to fluctuate and gradually decline. While these hormones are best known for their role in the menstrual cycle, their effects extend throughout the body, including the brain and nervous system.

This is why perimenopause can affect much more than your periods or cause physical symptoms such as hot flushes and night sweats. Hormonal changes, together with changes in sleep and stress, can also affect three important areas of everyday life:

  • Mood: Hormonal fluctuations can lead to changes in emotional wellbeing, with some women experiencing greater irritability, low mood or mood swings.
  • Mental clarity: Concentrating, processing information or remembering things can become more difficult during perimenopause and menopause.
  • Everyday energy: Tiredness and fatigue can become more common, particularly when combined with disrupted sleep, stress and the other changes happening during this transition.

Perimenopause most commonly begins in your 40s, although it can start earlier or later and may last for several years. One of the first signs is often a change in your menstrual cycle, with periods becoming less predictable, shorter, longer, heavier or lighter.

Menopause is reached when you have gone 12 consecutive months without a menstrual period. The years leading up to this point are known as perimenopause, while the years afterwards are referred to as postmenopause.

Every woman's experience is different. Some notice relatively few changes, while for others they can significantly affect how they feel and function from day to day. This is why menopause support can go beyond individual symptoms such as hot flushes - supporting mood, mental clarity and everyday energy can also be an important part of feeling more like yourself throughout this transition.

Feel the difference

Clinically studied support to help you feel your best through perimenopause and menopause.

90%

reported improved quality of life after 2 months with the branded blend of bergamot, lemon balm and peony (475 mg) present in MenoSpan* 

80%+

of women wished to continue taking the branded blend of bergamot, lemon balm and peony (475 mg)* present in MenoSpan after the clinical trial ended*

53%

reduction low mood scores with Affron® in its largest study to date**

11

published clinical studies on Affron®***

*Based on a randomised, double-blind, placebo-controlled study of the branded blend of bergamot, lemon balm and peony (475 mg)* in menopausal women. More than 80% of participants wished to continue taking the blended blend of bergamot, lemon balm and peony present in MenoSpan after the study ended.

**Based on a 12-week randomised, double-blind, placebo-controlled study of 202 adults experiencing low mood, taking 28 mg Affron® daily. This was Affron®'s largest clinical study at the time of publication.

***Affron® is backed by 11 published clinical studies across mood, stress, sleep and related areas of mental wellbeing.

What can you expect?

MenoSpan is designed for daily use, with its benefits building over time. Here’s what you can expect with consistent supplementation.

After 1 month

Support for mood, mental clarity and everyday energy

With consistent daily use, MenoSpan begins providing support across the areas that can become more difficult during menopause. Affron® supports a positive mood, Rhodiolife® helps with mental fatigue and concentration, while the branded blend of bergamot, lemon balm and peony and Vitamin B6 support tiredness and fatigue to help maintain everyday energy.

After 3 months

Noticeable improvements in how you feel

By three months, MenoSpan has been shown to significantly improve low mood, mental clarity, mood swings and fatigue in AVEA’s study in women aged 40+. Clinical research on its individual ingredients also found that 90% of women reported improved quality of life with the branded blend of bergamot, lemon balm and peony after two months, while Affron® was associated with a 53% reduction in depression scores in its largest study.

6 months & beyond

Ongoing support through menopause

With continued daily use, MenoSpan provides ongoing support to help you maintain a more positive mood, think clearly and feel less tired and fatigued as you move through perimenopause and menopause, without hormones.


* Based on customer surveys and scientific literature. Results may vary.

Frequently asked questions

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