Stabiliser

Reducose® (White Mulberry Leaf)

What is Reducose®?

Reducose® is a patented White Mulberry leaf extract rich in alkaloids and flavonoids. While they have recently gained popularity as ‘’superfoods’’ in the west, Mulberry leaves have been used in traditional medicine for ages in Asian countries for their blood sugar balancing benefits. In recent scientific studies, Reducose® has been shown to have multiple health benefits, including lowering blood sugar levels and possibly preventing cardiovascular diseases, obesity, and diabetes.

Where can it be found in nature?

The Mulberry (Morus) tree is native to China. It belongs to the Moraceae plant family and includes several species. Reducose® is extracted from White Mulberry leaves that are usually cultivated in Thailand, according to EU organic guidelines to achieve peak quality and sustainability.

What are its primary functions and benefits?

Clinical trials have shown significant decreases in post-meal blood glucose levels upon administration of Reducose®. It acts immediately at the very early stages of digestion by inhibiting the breakdown and absorption of carbs in your intestine, before they even reach your bloodstream. Your post-meal blood-sugar levels are thus successfully balanced without resulting in any spikes. As such, Reducose® also acts as a powerful weight management tool by allowing you to feel full for longer, and further propelling your body to increase its fats and lipids utilisation to provide energy.

Furthermore, a low insulin level enhances your brain's ability to exhibit improved memory, attention, and cognitive performance. Now, the cherry on top? There have been no reported side-effects with Reducose® as it remains unaltered, and is easily excreted from the body. The undigested carbs end up as prebiotics in the gut microbiome.

When it comes to delaying the onset of age-related diseases, Reducose® has additional metabolic health benefits. It mimics calorie restriction (while still allowing you to indulge in healthy diets), which has repeatedly been shown to increase lifespan by activating the sirtuin pathway, reducing oxidative stress and inflammation, as well as minimising the risks of cardiovascular and kidney diseases.

Why do we use Reducose® in our supplements?

We chose Reducose® as one of the key players in our Stabiliser, primarily for its ability to effectively reduce post-meal glucose spikes - a benchmark well-known for a healthy heart, healthy weight, and healthy ageing. This effect can also be attained through challenging methods like calorie restriction or intermittent fasting, Reducose® just makes it easier.

Additionally, Reducose® supports cellular and DNA repair by inducing its anti-inflammatory and antioxidant effects. It also frees up NAD+, a crucial molecule needed to activate the infamous ‘’longevity-genes’’ called sirtuins. Researchers have firmly established sirtuins' critical role as a longevity regulator, as they maintain healthy circadian rhythms and metabolisms.

Another factor triggering our choice for Reducose® is that its immediate blood-glucose effect can be easily monitored in real-time via technological innovations like Continuous Glucose Monitor (CGM) which enables you to understand your metabolism.

References:

1. Thondre et al, 2021. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomised, double-blind, placebo-controlled study. Nutrition & Metabolism; 18:41.
2. Wang et al, 2018. Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates. Medicine (2018) 97:34.
3. Li et al., 2018. Safety evaluation of mulberry leaf extract: acute, subacute toxicity and genotoxicity studies. Regulatory Toxicology and Pharmacology; 95: 220-226.
4. Lown et al, 2017. Mulberry extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: results of a randomized double-blind placebo controlled study. PLOS ONE.
5. Liu et al, 2016. Prevention effects and possible molecular mechanism of mulberry leaf extract and its formulation on rats with insulin sensitivity. PLOS ONE.
6. Lown et al, 2016. Mulberry extract Reducose® total blood glucose in normoglycaemic adults. Diabetes UK Annual Conference.
7. Marx et al, 2016. 28-day repeat dose toxicological study of an aqueous extract on Morus alba. L. Int. J. Tox.
8. Lown et al, 2015. Mulberry extract to modulate Blood glucose Responses in normoglycaemic adults (MULBERRY) study protocol for a randomized controlled study. TRIALS.
9. Asai et al. 2011. Effect of mulberry leaf extract enriched with DNJ on post prandial glycaemic control in subjects with impaired glucose metabolism. J. Diab. Inv.
10. Kim et al., 2015. Mulberry extract improves postprandial glucose response in prediabetic subjects. J. Med. Food.
11. Kimura et al, 2007. Food grade mulberry powder suppresses elevation of post-prandial blood glucose in humans. J. Agric. Food Chem.
12. Kojima et al, 2010. Effects of Mulberry leaf extract on blood lipid profiles. J. Clin. Biochem. Nutr.
13. Chung et al., 2-13. Acute intake of mulberry leaf extract affects postprandial glucose response after maltose loading. J. Func. Foods.
14. Mudra et al., 2007. Influence of mulberry leaf extract on blood glucose and breath hydrogen response to ingestion of 75g sucrose by type-2 diabetic and control subjects. Diabetes Care.
15. Nakamura et al., 2009. Suppressive response of confections containing the extractive from leaves of Morus alba on postprandial blood glucose and insulin. Nutr. & Metab.
16. Jozefczuk et al., 2017. Mulberry leaf extract decreases digestion and absorption of starch in healthy subjects. Adv. Med. Sci.
17. Phimarn et al., 2017. Meta-analysis of efficacy of Morus alba to improve blood glucose and lipid profile. Eu. J. Nutr.

Chromium Picolinate

What is Chromium Picolinate?

Chromium is an essential mineral which exists in several forms. Chromium Picolinate is one of the most bioavailable forms of Chromium that can be found in minute amounts in foods. Multiple scientific studies are now revealing the potential health benefits of supplementing with Chromium Picolinate, when it comes to reducing the risks of obesity, diabetes, and cardiovascular diseases.

Where can it be found in nature?

It is usually found in trace amounts in meat, whole grains, some fruits and vegetables, different spices, brewer's yeast, beer, and wine. However, the Chromium amounts present in these foods vary largely, depending on the agricultural and manufacturing processes involved. Thus, to exploit the potential health benefits that Chromium has in your body, it is a good idea to consider supplements, including our Stabiliser.

What are its primary functions and benefits?

Research in diabetic laboratory animals has shown the clear ability of Chromium Picolinate to regulate healthy blood-sugar levels by increasing the activity of insulin, and lowering the amounts of glucose that are left to circulate in the bloodstream. In fact, Chromium and insulin work cooperatively to prevent damages that are associated with a high blood-glucose level. In particular, Chromium Picolinate can help in preventing diabetes, obesity, heart diseases, strokes, oxidative stress, chronic inflammation and even neuropathy.

Chromium Picolinate supplementation has also shown enhanced performance amongst athletes and bodybuilders, in addition to promoting loss of fats instead of muscles. Furthermore, some forms of depression, typically those characterised by frequent mood changes and disturbed eating and sleeping patterns, may also be helped by the supplementation of Chromium. Recent evidence from the neuroscience field also uncovers the potential benefits of Chromium Picolinate in improving cognitive functioning and memory in adults.

Why do we use Chromium Picolinate in our supplements?

We chose Chromium Picolinate mainly for its assistance in reducing insulin resistance and glucose tolerance - the basis of multiple metabolic diseases, including obesity. Basically, Chromium is an essential mineral that has a crucial role in insulin signalling. As dietary Chromium is typically poorly absorbed, and as your Chromium levels decline with age, supplements like our Stabiliser become fundamental.

Besides, the high absorption rate of Chromium Picolinate may also play a role in maintaining a healthy cholesterol profile by reducing the excess fats in your bloodstream. Plus, it has been shown to simultaneously promote the relaxation of blood vessels and improve blood flow.

We ensured a verified and minimal dosage of Chromium Picolinate in our Stabiliser to prevent plausible interactions with other diabetes medication. Yet, we still recommend you talk to your healthcare provider if you also take diabetes medication.

References:

1. Brownley, K. A., Von Holle, A., Hamer, R. M., La Via, M., & Bulik, C. M. (2013). A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and Chromium (BEACh) study. Journal of psychosomatic research, 75(1), 36–42.
2. John B. Vincent, The Biochemistry of Chromium, The Journal of Nutrition, Volume 130, Issue 4, April 2000, Pages 715–718
3. Vincent JB. The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent. Sports Med. 2003;33(3):213-30.
4. Suksomboon N, Poolsup N, Yuwanakorn A. Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. J Clin Pharm Ther. 2014 Jun;39(3):292-306.
5. Pei D, Hsieh CH, Hung YJ, Li JC, Lee CH, Kuo SW. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism. 2006 Jul;55(7):923-7.

Berberine

What is Berberine?

Berberine is a polyphenol that can be found in the roots, rhizomes, and stem barks of many plant species. With a history of being used for over 2500 years in Ayurvedic and Chinese medicine, the natural supplement is a yellow compound also supported by scientific research for its multiple pharmacological properties, including lowering blood-sugar levels, improving insulin resistance, and reducing risks of cognitive impairment. Pubmed shows that research published on Berberine is on a steady rise, with over 630 papers published in 2020 alone.

Where can it be found in nature?

Many plant species contain Berberine including goldthread, Oregon grape, and barberry. Plants of this genus are often used against inflammation, infectious diseases, diabetes, constipation, and other pathologies. While multiple studies revealed the beneficial effects of supplemental berberine and barberry extracts, the relative amount of fresh or dried barberries to be consumed remains unclear. Another reason to consider our Stabiliser supplement!

What are its primary functions and benefits?

Acting at molecular level, Berberine’s health benefits have been intensively studied in clinical trials for lowering blood sugar, lipids, high cholesterol and hypertension. Essentially, it activates an enzyme needed to decrease insulin resistance.

Insulin resistance occurs when your body needs more and more insulin to function properly - the leading cause of Type II diabetes, inflammation and cardiovascular diseases globally. Decreasing insulin resistance not only reduces the risk of such chronic diseases, but it also optimises metabolism and weight management by stimulating better glucose uptake, and the effective usage of fats as fuel.

Furthermore, no significant difference has been observed between the effects of Berberine and other Type II diabetes prescription drugs. In fact, both studies show similar declines in HbA1c levels (a marker of glucose management in diabetics), with no remarkable side effects from Berberine. As a matter of fact, a linear correlation between circulating HbA1c levels and cognitive decline (regardless of diabetic status) has also been observed. Thus, supplementing with Berberine will not only improve your blood-sugar levels, but also enhance your immune system and promote healthy brain cell production.

Why do we use Berberine in our supplements?

We chose Berberine because of its potential to activate the crucial enzyme AMPK, which essentially generates the same benefits as exercising, dieting or weight management - the healthy lifestyle modifications you know you should implement when it comes to improving your health, but which can sometimes still be challenging. On the plus side, Berberine has the same effects as increasing exercise and restricting your calorie intake altogether.

Additionally, when used in combination with other agents, Berberine has consistently exhibited multiple pharmacological and therapeutic actions, such as antioxidant and immunomodulatory effects, protective action on the cardiovascular system, liver and kidney, endothelial relaxation, as well as regulator of glucose metabolism. This is yet another major reason why we chose Berberine to partner with the other two ingredients in our Stabiliser supplement. For instance, Berberine acts by lowering your fasting glucose levels, while Reducose on the other hand, will act on your post-meal glucose levels.

As higher doses of Berberine can interfere with other medications, our Stabiliser supplement contains the ideal concentration of Berberine that will help extend your lifespan and metabolism without causing any discomfort.

References:

1. Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation - PMC
2. Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) Nature Communications
3. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression
4. Berberine and probiotics combo successful in reducing blood sugar level in diabetic patients – China 12-week RCT
5. Comparison Among Garlic, Berberine, Resveratrol, Hibiscus sabdariffa, Genus Zizyphus, Hesperidin, Red Beetroot, Catha edulis, Po
6. Berberine Prolongs Life Span and Stimulates Locomotor Activity of Drosophila melanogaster - PMC
7. Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis
8. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine
9. Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes
10. Clinical Applications for Berberine