4.8/5
SkinSpan™ Advanced Skin Serum is the result of our effort to develop the most effective solution to skin ageing. While developing our best-selling longevity supplements, it became clear that we could further optimise results by delivering selected compounds directly to the skin. Our only serum formula is designed to function as a supplement consumed through the skin and work alongside other orally consumed longevity supplements for a more complete approach to skin health - from inside and outside.
SkinSpan™ Advanced Skin Serum has been designed to target the four core biological drivers of skin ageing:
While conventional serums focus only on surface hydration, SkinSpan™ Advanced Skin Serum is designed to target the four core biological root causes of skin ageing deep within the skin cells all in one formula.
Developed in Switzerland and designed to complement our oral longevity formulations, SkinSpan™ Advanced Skin Serum combines NAD⁺ activation, autophagy stimulation, exosome-driven collagen renewal, and advanced skin-barrier repair to counteract the root causes of visible ageing and support long-term skin regeneration.
With age, NAD⁺ levels decline sharply, reducing the energy skin cells need for repair and healthy renewal. RejuveNAD™ - a bioactive extract derived from nutrient-rich sunflower sprouts and developed through precision biotechnology - supports the skin’s own NAD⁺ production by upregulating NAMPT, the rate-limiting enzyme in the NAD⁺ biosynthesis pathway. By boosting NAD+ levels directly in the skin, this longevity serum restores the energy of the skin cells to youthful levels faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin.
With age, NAD⁺ levels decline sharply, reducing the energy skin cells need for repair and healthy renewal. RejuveNAD™ - a bioactive extract derived from nutrient-rich sunflower sprouts and developed through precision biotechnology - supports the skin’s own NAD⁺ production by upregulating NAMPT, the rate-limiting enzyme in the NAD⁺ biosynthesis pathway. By boosting NAD+ levels directly in the skin, this longevity serum restores the energy of the skin cells to youthful levels faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin.
Autophagy - the cell’s natural renewal and detoxification system - slows dramatically with age, leading to older skin cells with dull, rough texture, and accumulated cellular waste. Cellaigie™ is a biomimetic peptide made from the same natural amino acids found in your skin that was optimized using AI technology. It targets mTOR, a central regulator for cell growth, stimulating skin cells to focus on renewal, similar to the benefits of cellular fasting. By reactivating autophagy pathways, it accelerates the clearance of damaged components and restores efficient cellular renewal. The result is smoother texture, renewed radiance, and visibly more youthful, resilient skin over time.
Ageing reduces the skin’s production of collagen III, collagen XVI, and elastin - key fibres responsible for firmness, elasticity, and structural support. PhytoCellTec™ Exosomes, derived from Goji berry stem cells, act as targeted cellular messengers, enhancing communication with specific skin cells, the fibroblasts, to stimulate fresh collagen and elastin production. This helps rebuild dermal density, reduce fine lines and wrinkles, and improve long-term structural resilience. As the serum increases the collagen production in fibroblasts, its effectiveness can be further enhanced with our Collagen Activator which ensures the body is supplied with the right amount and the optimised form of the building blocks, e.g. amino acids, needed for new collagen formation.
Ageing reduces the skin’s production of collagen III, collagen XVI, and elastin - key fibres responsible for firmness, elasticity, and structural support. PhytoCellTec™ Exosomes, derived from Goji berry stem cells, act as targeted cellular messengers, enhancing communication with specific skin cells, the fibroblasts, to stimulate fresh collagen and elastin production. This helps rebuild dermal density, reduce fine lines and wrinkles, and improve long-term structural resilience. As the serum increases the collagen production in fibroblasts, its effectiveness can be further enhanced with our Collagen Activator which ensures the body is supplied with the right amount and the optimised form of the building blocks, e.g. amino acids, needed for new collagen formation.
As the skin ages, the skin barrier becomes thinner and more reactive, resulting in dryness, irritation, increased transepidermal water loss (TEWL), and heightened sensitivity. Therefore, any strategy to rejuvenate skin cells needs to include a reinforcement of the skin barrier to protect the achieved results. In our serum niacinamide, a bioactive form of Vitamin B3, boosts ceramides and essential lipids to rebuild barrier integrity. Ectoin®, discovered in microorganisms that survive harsh desert and salt-lake environments, stabilises cellular structures and protects the skin under environmental stress. Beta-Glucan, naturally derived from yeast, soothes irritation and supports extracellular matrix repair.
With age, NAD⁺ levels decline sharply, reducing the energy skin cells need for repair and healthy renewal. RejuveNAD™ - a bioactive extract derived from nutrient-rich sunflower sprouts and developed through precision biotechnology - supports the skin’s own NAD⁺ production by upregulating NAMPT, the rate-limiting enzyme in the NAD⁺ biosynthesis pathway. By boosting NAD+ levels directly in the skin, this longevity serum restores the energy of the skin cells to youthful levels faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin.
Autophagy - the cell’s natural renewal and detoxification system - slows dramatically with age, leading to older skin cells with dull, rough texture, and accumulated cellular waste. Cellaigie™ is a biomimetic peptide made from the same natural amino acids found in your skin that was optimized using AI technology. It targets mTOR, a central regulator for cell growth, stimulating skin cells to focus on renewal, similar to the benefits of cellular fasting. By reactivating autophagy pathways, it accelerates the clearance of damaged components and restores efficient cellular renewal. The result is smoother texture, renewed radiance, and visibly more youthful, resilient skin over time.
Ageing reduces the skin’s production of collagen III, collagen XVI, and elastin - key fibres responsible for firmness, elasticity, and structural support. PhytoCellTec™ Exosomes, derived from Goji berry stem cells, act as targeted cellular messengers, enhancing communication with specific skin cells, the fibroblasts, to stimulate fresh collagen and elastin production. This helps rebuild dermal density, reduce fine lines and wrinkles, and improve long-term structural resilience. As the serum increases the collagen production in fibroblasts, its effectiveness can be further enhanced with our Collagen Activator which ensures the body is supplied with the right amount and the optimised form of the building blocks, e.g. amino acids, needed for new collagen formation.
As the skin ages, the skin barrier becomes thinner and more reactive, resulting in dryness, irritation, increased transepidermal water loss (TEWL), and heightened sensitivity. Therefore, any strategy to rejuvenate skin cells needs to include a reinforcement of the skin barrier to protect the achieved results. In our serum niacinamide, a bioactive form of Vitamin B3, boosts ceramides and essential lipids to rebuild barrier integrity. Ectoin®, discovered in microorganisms that survive harsh desert and salt-lake environments, stabilises cellular structures and protects the skin under environmental stress. Beta-Glucan, naturally derived from yeast, soothes irritation and supports extracellular matrix repair.
Formulated with traceable, clinically studied ingredients. Developed and manufactured in Switzerland.
RejuveNAD™
Derived from sustainably cultivated organic sunflower sprouts, RejuveNAD™ is a clinically studied plant-based ingredient that naturally boosts the levels of NAD⁺, the key molecule for cellular energy by enhancing the expression of the rate-limiting enzyme NAMPT. By boosting NAMPT, RejuveNAD™ allows skin cells to naturally generate more NAD⁺, supporting faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin over time.
Niacinamide
Niacinamide, a form of vitamin B3, is a clinically studied ingredient that supports skin barrier function, enhances cellular energy, and promotes skin renewal. It helps reduce redness, improves uneven skin tone, and strengthens the skin’s natural defenses against environmental stress.
Cellaigie™
Cellaigie™ is a biomimetic peptide made from the same natural amino acids found in your skin that was optimized using AI technology to work in harmony with your body's cellular intelligence. It enhances autophagic activity, triggers cellular clearance, optimizes energy through glycophagy, and reduces markers of cellular senescence. By prioritizing skin cell renewal and efficiency, it supports firmer, more resilient, and radiant skin.
PhytoCellTec™ Exosomes
Exosomes are tiny packets that cells use to communicate with each other. They transport important information and signals from one cell to the next. This helps the body repair tissue, reduce inflammation and guide healing processes. PhytoCellTec exosomes are derived from goji berries and stimulate the release of the skin’s own stem cell exosomes. This boosts the production of collagen III, collagen XVI and elastin and strengthens the extracellular matrix, resulting in firmer, more youthful-looking skin.
Ectoin
A stress-protective compound produced by microorganisms that thrive in extreme environments. It stabilizes cell membranes, preserves protein structure, and reduces oxidative damage, supporting skin barrier integrity, resilience, and long-lasting hydration.
Low Molecular Weight Hyaluronic Acid
A smaller, more penetrative form of the skin's natural moisture molecule. Unlike traditional hyaluronic acid that sits on the surface, its reduced molecular size allows it to travel deeper into the skin layers, delivering hydration where it's needed most. By attracting and binding up to 1000 times its weight in water, it plumps the skin, smooths fine lines, and supports the skin's structural matrix for a fuller, more youthful appearance with long-lasting moisture retention.
Betaine
A natural osmolyte (water-attracting molecule) derived from sugar beets, found naturally in skin and throughout nature. It acts as a cellular water manager, attracting and holding moisture while protecting proteins from damage. By maintaining optimal hydration balance and strengthening the skin barrier, betaine ensures skin stays resilient, comfortable, and moisturized even under environmental stress.
Beta Glucan
A protective polysaccharide extracted from baker's yeast that activates the skin's natural repair and defense systems. By communicating with immune cells in the skin, it stimulates healing processes, accelerates recovery from stress and damage, and strengthens the skin barrier. This "repair and defense molecule" reduces inflammation, locks in moisture, and enhances skin resilience.
Diglycerin
A humectant derived from glycerin that provides superior moisture-binding capacity with enhanced skin compatibility. Its dual glycerin structure allows it to penetrate more effectively while attracting and retaining water in the skin, creating a reservoir of hydration that lasts. Unlike simple glycerin, diglycerin offers a lighter, more elegant feel while delivering deep, sustained moisture that supports skin barrier function and maintains optimal hydration levels throughout the day.
Manufactured in Switzerland
Formulated by experts
Sustainable Packaging
Clinically proven results
Vegan
SkinSpan™ Advanced Skin Serum is AVEA’s only serum formulation delivering key ingredients directly to the skin. Developed with leading longevity scientists in Switzerland, it’s designed to complement our oral formulations and target the same core cellular mechanisms directly via absorption into the skin.
It targets the four core biological drivers of skin ageing:
SkinSpan™ Advanced Skin Serum supports the same longevity pathways as our supplements with direct delivery to your skin cells where ageing is most visible.
When used together with AVEA’s oral formulations even stronger effects can be achieved as the supplements work internally, providing the nutrients and precursors your body needs to build collagen, repair cells, and strengthen the skin barrier and the serum then complements this externally by boosting cellular energy (NAD⁺), activating renewal (autophagy), stimulating collagen and elastin production directly in the skin cells.
This comprehensive approach to skin ageing from the inside and outside offers a more comprehensive and effective way to maintain firmness, smoothness, and overall skin health for the long run.
Use morning and night on damp skin. Face, neck, decollete.
Manufactured in Switzerland
Formulated by Experts
Tested by 3rd Parties
Sustainable Packaging
Clinically proven results
Vegan
No parabens, No cruelty, No fragrances, No PEGs
INGREDIENTS:
Aqua (Water), Glycerin, Dimethicone, Diglycerin, Niacinamide, Betaine, Dipentaerythrityl Hexacaprylate/Hexacaprate, Ectoin, Maltodextrin, 1,2-Hexanediol, Caprylyl Methicone, Sodium Acrylates Copolymer, Hydroxyacetophenone, Cetearyl Dimethicone Crosspolymer, Isomalt, Lecithin, Polyacrylate Crosspolymer-6, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Hyaluronate, Tetrasodium Glutamate Diacetate, Potassium Chloride, Sodium Carboxymethyl Beta-Glucan, Helianthus Annuus (Sunflower) Sprout Extract, Sorbitan Isostearate, Caprylyl Glycol, Lycium Barbarum Callus Culture Extract, Acetyl Tetrapeptide-2
Worldwide shipping, free shipping on orders over £50/€50/CHF50, 3-5 day average delivery time.
Most topical skincare products today are designed to temporarily fix the damage caused by exposure to sun, pollution, and the effects of ageing. This is mostly achieved by rehydrating the epidermis and forcing it to firm up in order to achieve temporary relief from dryness and fine lines. However, skin ageing begins not at the epidermis, but deep within the skin’s cells, where fundamental processes of repair, energy production, and communication gradually slow down. With age, skin cells experience:
Traditional skincare products may mask these effects, but they cannot reactivate the underlying skin biology.
Our Longevity skincare takes a fundamentally different approach: instead of treating symptoms on the surface, it supports the cellular pathways that keep skin youthful. This includes restoring cellular energy (ATP/NAD⁺), reactivating autophagy, supporting fibroblast communication, strengthening the skin barrier, and protecting against oxidative and glycation stress.
By optimising these longevity pathways, the skin can naturally produce more collagen and elastin, repair damage more efficiently, maintain hydration, and stay more resilient over time. These results are further compounded when combined with oral supplementation for a more inside-out approach to skin health.
Developed in collaboration with leading longevity scientists in Switzerland, SkinSpan™ Advanced Skin Serum applies the principles of cellular longevity directly to the skin, targeting the biological processes that drive ageing, rather than its visible symptoms.
Where most longevity-inspired serums focus on one aspect of skin ageing, such as antioxidant defence or collagen stimulation, SkinSpan™ Advanced Skin Serum works across four key biological pathways proven to influence how the skin functions and ages:
Unlike conventional or even other longevity-focused serums, SkinSpan™ Advanced Skin Serum doesn’t rely on a single “hero” ingredient. Its formulation reflects a systems biology approach to skin ageing, which is what allows results to compound over time.
From a scientific perspective, skin ageing is influenced by both internal and external processes:
Our best selling Collagen Activator features Colgevity™, a patented, 100% vegan collagen precursor complex to provide the body with specifically optimised building blocks for collagen synthesis, leading to higher and more efficient collagen production in the whole body.
Our SkinSpan™ Advanced Skin Serum acts directly on skin cells, supporting NAD⁺ restoration for more cell energy and cellular renewal, as well as further stimulating the skin cells’ own collagen & elastin production. Our SkinSpan™ Supplement, on the other hand, delivers Hyaluronic Acid, Ceramosides™, and PhytoCellTec™ Md Nu to improve hydration and then strengthen the skin barrier of the renewed cells.
Used all together, you have the most complete inside-out approach to skin health.
Feel the dıfference
*Based on our customer survey; N = 450.
We designed SkinSpan™ Advanced Skin Serum to apply the core longevity principles we have in our supplements directly to the skin, using clinically studied ingredients that reactivate cellular energy metabolism (RejuveNAD™), promote cellular recycling (Cellaigie™), and enhance fibroblast signalling (PhytoCellTec™ Exosomes) to further enhance the effects of your supplementation routine. Deeper improvements tend to occur progressively as the skin’s repair efficiency is restored over time
During the first weeks, increased hydration and enhanced barrier function are typically the earliest observable changes. As the skin retains moisture more effectively, dryness and roughness begin to diminish. Early improvements in smoothness and suppleness may become noticeable as cellular turnover and repair processes are supported.
With continued use, the pathways involved in collagen production, autophagy, and barrier reinforcement become more active. This can lead to visible softening of fine lines, improved elasticity, and a more even texture. The skin may also show greater resilience to environmental stressors as barrier integrity and cellular repair efficiency improve.
Clinical data on the active ingredients indicate that longer-term use can lead to measurable changes, including reductions in wrinkle depth (up to ~16% in studies on key active ingredients), improvements in firmness and elasticity (around 8–12%), and increases in luminosity. Skin often appears more balanced, hydrated, and structurally supported, reflecting deeper improvements in the biological processes that influence ageing.
*Based on customer surveys and scientific literature. Results may vary
Most anti-ageing serums target symptoms of ageing - dryness, fine lines, or loss of elasticity by stimulating or hydrating the skin. SkinSpan™ Advanced Skin Serum is built on cellular longevity science, designed to restore the fundamental biological processes that slow with age.
While many “longevity” formulas rely on a single mechanism (e.g., NAD⁺ boosters or peptides), SkinSpan™ Advanced Skin Serum integrates four proven pathways - cellular energy & renewal, collagen & elastin support, skin barrier defence & hydration. This systems-biology approach helps optimise how the skin generates energy, clears damage, and maintains structural integrity, rather than simply treating what’s visible at the surface.
When we say SkinSpan™ Advanced Skin Serum is based on longevity science, we mean that its formulation is built on the same biological principles used in cellular longevity research, i.e. the field that studies why cells age, how they lose function, and how we can maintain their performance over time.
In the context of skincare, it means that rather than temporarily addressing surface symptoms (e.g. hydrating the epidermis, exfoliating, temporarily tightening the skin, etc.) like most traditional skincare solutions , longevity skincare formulas are instead optimised to support long-term skin cellular health.
We designed SkinSpan™ Advanced Skin Serum to apply the core longevity principles we have in our supplements directly to the skin, using clinically studied ingredients that reactivate cellular energy metabolism (RejuveNAD™), promote cellular renewal (Cellaigie™), enhance fibroblast signalling (PhytoCellTec™ Exosomes) to further enhance the effects of your supplementation routine for a more complete inside-out approach to skin longevity.
NAD⁺ and autophagy are two fundamental pillars of cellular function that determine how effectively the skin repairs damage, produces collagen, and resists visible ageing.
NAD⁺ (nicotinamide adenine dinucleotide) is a molecule every cell needs to produce energy, repair DNA, and maintain healthy function. But NAD⁺ levels decline sharply with age, including in skin cells. When NAD⁺ drops:
Supporting NAD⁺ metabolism helps skin cells regain the energy required for repair, renewal, and healthy collagen synthesis, all of which directly influence firmness, elasticity, and skin resilience. In SkinSpan™ serum, this is addressed through RejuveNAD™, which helps activate the skin’s natural NAD⁺ cycle.
Autophagy is the process through which cells “clean out” damaged proteins and waste so they can function optimally. As autophagy slows with age:
Reactivating autophagy essentially tells skin cells to renew themselves, improving smoothness, clarity, and overall vitality. SkinSpan™ serum supports this with Cellaigie™, a peptide that encourages a renewal-focused state similar to the benefits seen in cellular detox pathways.
Together, NAD⁺ and autophagy determine how well skin cells can:
When both pathways decline (which naturally happens with age), visible aging accelerates. When both are supported, skin can behave more like it does in its younger years, renewing faster, repairing better, and maintaining healthier structure over time. This effect is further enhanced by supporting the skin with oral supplementation for a more complete inside-out approach.
Yes. SkinSpan™ Advanced Skin Serum was formulated without retinol, exfoliating acids, or fragrance - all common causes of irritation. Instead, it uses bioadaptive active ingredients such as Ectoin and Beta-Glucan, which have been clinically shown to reduce redness and strengthen barrier tolerance.
Ectoin and Betaine functions as an osmolyte, stabilising cell membranes under stress, while Beta-Glucan enhances skin recovery and hydration. Combined with Niacinamide, which improves lipid synthesis and barrier function, the serum not only avoids irritation but actively improves skin sensitivity and resilience.
The formula has been dermatologically tested.
Yes. SkinSpan™ Advanced Skin Serum is compatible with most active ingredients, including vitamin C, niacinamide, and exfoliating acids. It can also be layered with retinol-based products.
If using strong retinoids or chemical exfoliants, apply SkinSpan™ Advanced Skin Serum before those active ingredients to reduce irritation and reinforce the barrier. Its barrier-repairing ingredients (Niacinamide, Beta-Glucan, Ectoin®) help maintain balance in routines with potent active ingredients.
Always follow with a moisturizer and daily SPF to preserve the skin’s integrity.
Apply one to two pumps to clean, dump skin twice daily - morning and evening.
Gently press into the face, neck, and décolletage until absorbed. Use before moisturizer or sunscreen during the day, and before your night cream in the evening.
For deeper results, pair with AVEA’s oral formulations (Collagen Activator and SkinSpan) for a more complete inside-out approach to skin health.
A pea-sized amount (one pump) is sufficient for the entire face. The serum is highly concentrated - our formulation comprises clinically studied active ingredients - so using more does not enhance results. Consistency, not quantity, drives the best results.
SkinSpan™ Advanced Skin Serum is developed and manufactured in Switzerland under GMP-certified conditions.
The formulation was created in collaboration with leading longevity scientists to ensure precision, stability, and bioavailability of each active compound. Each ingredient is sourced from traceable suppliers with clinical validation and tested for purity and safety.
Yes, they are designed to work synergistically.
The serum targets the skin’s surface and cellular interface - restoring NAD⁺, autophagy and cell renewal.
The Collagen Activator supplies the molecular building blocks and cofactors needed for new collagen synthesis, while the SkinSpan™ Supplement supports hydration, ceramide production, and cellular renewal.
Together, they reinforce each other’s pathways, creating a closed-loop system that supports skin structure, moisture, and biological longevity across all layers.
Yes. The efficacy of SkinSpan™ Advanced Skin Serum is supported by extensive ingredient-level research:
All formulations are dermatologically tested in Switzerland to verify safety, tolerability, and measurable improvement in key skin parameters.* Claims reflect the proven effects of each active ingredient, as demonstrated in clinical studies.
SkinSpan™ Advanced Skin Serum enhances cellular performance while it’s used, much like exercise strengthens muscle. Once discontinued, the biological benefits (improved NAD⁺ activity, barrier integrity, collagen signalling) gradually decline as natural ageing processes resume.
However, stopping use will not cause a rebound effect or deterioration; the skin will simply return to its baseline rate of renewal. For sustained improvement, consistent application maintains the biological optimisation SkinSpan™ Advanced Face Serum helps achieve.
At AVEA, every formulation begins with a deep understanding of the biological processes that drive ageing – and how we can influence them. Our work is grounded in the latest findings from the fields of cellular health, metabolic and longevity science.
Led by our Co-Founder and Chief Science Officer, Sophie Chabloz, our in-house science team partners with world-class longevity researchers and biotech experts from leading academic institutions. Together, we translate complex, peer-reviewed research into targeted, effective supplement formulas designed to support cellular function, resilience, and long-term vitality.
Each supplement we create is based on clinically studied ingredients, optimised for bioavailability, and rigorously tested – so that what works in the lab also works in your daily life.
Your supplements will be dispatched from our NL warehouse within 24 hours.
We ship internationally and offer a variety of shipping options:
All available shipping methods – along with estimated delivery times and final costs – will be displayed during checkout.
If your country isn’t listed at checkout, feel free to contact our customer service team at support@avea-life.com, and we’ll be happy to explore possible solutions.
The full benefits of skincare cosmetics take time to develop. Many customers notice initial improvements within the first month, while the full effect typically unfolds after 2–3 months. Since everyone is unique, results may vary. That’s why we recommend following your new routine for at least 3 months.
If you’re not satisfied after this period, you can make use of our 90-day money-back guarantee.
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