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4.8/5 800+ reviews

SkinSpan™  System

SkinSpan™ System  is the result of years of research into the ideal ingredient combination for skin longevity. Our researchers realised that while we fundamentally believe in delivering nutrients systemically as oral supplements, we can add additional efficacy by delivering selected compounds topically to the skin for a more complete approach to skin health - from inside and outside.

The SkinSpan system combines our Advanced Serum and Supplement capsules to counter skin ageing through 4 major levers:

  • Accelerates skin cell renewal: Cellaigie™ peptides and PhytoCellTec™ Apple Stem cells accelerate skin cell renewal back to youthful levels
  • Restores NAD⁺ levels: RejuveNAD™ boosts NAMPT to increase the skin’s own NAD⁺ production, countering natural decline
  • Increases Collagen & Elastin production: PhytoCellTec™ Exosomes from Goji berries, enhances fibroblasts activity to stimulate fresh collagen and elastin production.
  • Regenerates and strengthens skin barrier: Niacinamide, Hyaluronic acid and Beta-Glucan restore and strengthen the skin barrier, preventing moisture and collagen loss


While most skincare solutions focus on fighting symptoms and provide superficial remedies such as surface level only hydration, the SkinSpan™ System is designed to target the core biological root causes of skin ageing deep within the skin cells.

Manufactured in Switzerland

Manufactured in Switzerland

Based on cutting-edge research

Try without risk

Try without risk

90 days money back guarantee

The first skincare system combining topical and systemic components.

Accelerates Cellular Renewal

Our skin cells renew themselves continuously, unfortunately this process slows down dramatically with age, leading to older skin cells with dull, rough texture, and accumulated cellular waste. Cellaigie™, a peptide (serum) made from natural amino acids optimized using AI technology and PhytoCellTec™ Md Nu (capsules), a clinically studied plant stem cell extract, stimulate skin cells to focus on renewal. By reactivating cellular renewal we get fresher cells, resulting in smoother texture, renewed radiance, and visibly more youthful, resilient skin over time.

Restores Cellular Energy

With age, NAD⁺ levels decline sharply, reducing the energy skin cells need for repair and healthy renewal. The serum contains RejuveNAD™ - a bioactive extract derived from nutrient-rich sunflower sprouts and developed through precision biotechnology - that penetrates the skin and supports the cell’s own NAD⁺ production by upregulating key enzymes in the NAD+ Production. By boosting NAD+ levels directly in the skin, this longevity serum restores the energy of the skin cells to youthful levels, promoting faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin.

Increases Collagen & Elastin Production

Ageing and a weakening skin barrier naturally lead to a decline in the skin cells. Elastin and Collagen levels, key components for well moisturised and plump skin, PhytoCellTec™ Stem Cells from Swiss Apples (capsules) and Exosomes from Goji berry stem cells (serum), act as targeted cellular messengers, enhancing communication with specific skin cells, the fibroblasts, to stimulate fresh collagen and elastin production. This helps rebuild dermal density, reduce fine lines and wrinkles, and improve long-term structural resilience.

Strengthens & Protects the Skin Barrier

As the skin ages, the skin barrier becomes thinner and more reactive, resulting in dryness, irritation, increased transepidermal water and collagen loss. Therefore, any strategy to rejuvenate skin cells needs to include a reinforcement of the skin barrier to protect the achieved results. The serum combines Ectoin®, a natural molecule discovered in microorganisms that survive harsh desert and salt-lake environments with niacinamide and Beta-Glucan to rebuild and repair the skin barrier and protect the skin from environmental stress. The supplement capsules reinforce this effect with high-molecular weight Hyaluronic Acid with Ceramosides™, a patented complex of plant-derived ceramides, to deliver intensive hydration while strengthening the skin’s protective barrier.

The science behind longevity skincare.

Skin health basics

Most topical skincare products today are designed to temporarily fix the damage caused by exposure to sun, pollution, and the effects of ageing. This is mostly achieved by rehydrating the epidermis and forcing it to firm up in order to achieve temporary relief from dryness and fine lines. However, skin ageing begins not at the epidermis, but deep within the skin’s cells, where fundamental processes of repair, energy production, and communication gradually slow down. With age, skin cells experience:

  • Slower cell renewal, leading to rough and damaged old skin cells and cellular waste to accumulate.
  • A decline in cellular energy (ATP, NAD⁺), reducing the skin cells capacity to repair and regenerate.
  • Reduced fibroblast activity, leading to decreased collagen and elastin production.
  • A weakening skin barrier, causing moisture loss, irritation, and increased sensitivity.
  • Greater vulnerability to environmental stressors such as UV exposure, pollution, and oxidative stress.

Traditional skincare products may mask these effects, but they cannot reactivate the underlying skin biology.

Our Longevity focused SkinSpan system takes a fundamentally different approach: instead of treating symptoms on the surface, it supports the cellular pathways that keep skin youthful. This includes accelerating cellular renewal, restoring cellular energy (ATP/NAD⁺), supporting fibroblast activity, strengthening the skin barrier, and protecting against oxidative stress. 

By delivering synergetic ingredients from the inside through supplement capsules and topically via the serum from the outside we can achieve more complete support of the skin cells and more convincing results.

CLINICALLY BACKED FORMULAS

Clinical studies on SkinSpan ingredients show:

81%

noticed that their skin felt smoother (PhytoCellTec™ Md Nu)1

15.3%

Crow’s feet wrinkle depth reduction after 42 days (RejuveNAD™)2

8.7%

increase in dermis thickness (DracoBelle™ Nu)3

14 days

to better skin quality & reduced wrinkle depth (CeramosidesTM)4

1. ​​Baumann, Julia & Wandrey, Franziska & Nowak, Kathrin & Grothe, Torsten. (2024). Nutritional supplementation of an apple callus extract to target epidermal aging. Journal of Food, Nutrition and Diet Science. 18-28. 10.55976/fnds.22024123718-28 2. https://mibellebiochemistry.com/rejuvenadtm3. Baumann, Julia & Bönzli, Eva & Wandrey, Franziska & Grothe, Torsten. (2025). Moldavian Dragonhead Extract: A Natural Collagen-Booster to Target Skin Aging. OBM Geriatrics. 09. 1-22. 10.21926/obm.geriatr.2502305 4. Kern, C., Dudonné, S., & Garcia, C. (2024). Dietary supplementation with a wheat polar lipid complex improves skin conditions in women with dry skin and mild-to-moderate skin aging. Journal of cosmetic dermatology, 23(4), 1320–1330. https://doi.org/10.1111/jocd.16130

*Based on our customer survey; N = 450.

SkinSpan System™ 

For deep, lasting skin health
Add to Cart

Clean, transparent ingredients backed by science.

Formulated with traceable, clinically studied ingredients. Developed and manufactured in Switzerland.

RejuveNAD™

Derived from sustainably cultivated organic sunflower sprouts, RejuveNAD™ is a clinically studied plant-based ingredient that naturally boosts the levels of NAD⁺, the key molecule for cellular energy by enhancing the expression of the rate-limiting enzyme NAMPT. Restored NAD+ levels means that your cells' powerplants, the mitochondria, have more energy to repair, counteract aging-induced epigenetic alterations, and suppress the formation of senescent “zombie” cells. By supporting cellular energy,  RejuveNAD™ helps restore your skin’s cells energy level to a youthful state and therefore promotes healthy skin on a holistic level.

Ceramosides™

Concentrated gluten free phytoceramides extracted from wheat that help rebuild the skin’s natural lipid barrier, locking in moisture and protecting against external irritants. They improve skin smoothness, hydration, and elasticity – clinically shown to reduce fine lines and dryness.

Hyaluronic Acid

A deeply hydrating molecule naturally occurring in the human body that can bind up to 1,000 times its weight in water. It helps visibly plump the skin, smooth the appearance of fine lines, and maintain optimal moisture levels – leaving the complexion softer, smoother, and more radiant.

PhytoCellTec™ Md Nu

A patented plant stem cell extract derived from a rare Swiss apple variety. It helps protect human skin stem cells, support cellular renewal, and delay signs of skin ageing – contributing to smoother, firmer, and more youthful skin³.

Niacinamide

Niacinamide, a form of vitamin B3, is a clinically studied ingredient that supports skin barrier function, enhances cellular energy, and promotes skin renewal. It helps reduce redness, improves uneven skin tone, and strengthens the skin’s natural defenses against environmental stress.

Cellaigie™

Cellaigie™ is a biomimetic peptide made from the same natural amino acids found in your skin that was optimized using AI technology to work in harmony with your body's cellular intelligence. It enhances autophagic activity, triggers cellular clearance, optimizes energy through glycophagy, and reduces markers of cellular senescence. By prioritizing skin cell renewal and efficiency, it supports firmer, more resilient, and radiant skin.

PhytoCellTec™ Exosomes

Exosomes are tiny packets that cells use to communicate with each other. They transport important information and signals from one cell to the next. This helps the body repair tissue, reduce inflammation and guide healing processes. PhytoCellTec exosomes are derived from goji berries and stimulate the release of the skin’s own stem cell exosomes. This boosts the production of collagen III, collagen XVI and elastin and strengthens the extracellular matrix, resulting in firmer, more youthful-looking skin.

DracoBelle™ Nu

Also known as Moldavian Dragonhead Extract, this clinically studied plant compound boosts cellular stress resistance and stimulates collagen production⁴. It also activates key cellular longevity pathways (like AMPK and FOXO), which support skin firmness and elasticity⁵.

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Manufactured in Switzerland

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Formulated by experts

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Sustainable Packaging

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Clinically proven results

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Vegan

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Halal

Timeline of expected benefits

SkinSpan™ System was designed by applying the most the latest insights from longevity science on skin ageing. The combination of the supplement capsules and the serum provide the skin with a synergetic combination of nutrients from the inside and outside. Improvements occur progressively as the skin cell’s renewal rate accelerates, repair efficiency is restored and the skin barriers strengthens.

After 1 Month

Improved hydration & smoother texture

During the first weeks, increased hydration and enhanced barrier function are typically the earliest observable changes. As the skin retains moisture more effectively, dryness and roughness begin to diminish. Early improvements in smoothness and suppleness may become noticeable as cellular turnover and repair processes are supported.

After 2 Months

Enhanced firmness and resilience

With continued use, the pathways involved in collagen production, autophagy, and barrier reinforcement become more active. This can lead to visible softening of fine lines, improved elasticity, and a more even texture. The skin may also show greater resilience to environmental stressors as barrier integrity and cellular repair efficiency improve.

After 3 Months

Measurable improvements in structure and radiance

Clinical data on the active ingredients indicate that longer-term use can lead to measurable changes, including reductions in wrinkle depth (up to ~16% in studies on key active ingredients), improvements in firmness and elasticity (around 8–12%), and increases in luminosity. Skin often appears more balanced, hydrated, and structurally supported, reflecting deeper improvements in the biological processes that influence ageing.

Why choose AVEA?

Frequently asked questions

The AVEA Promise

Supplements crafted to support lasting energy and health. Developed with leading longevity experts. Clinicially tested. Swiss made.

Born in Switzerland

Every formula at AVEA reflects our roots in Swiss scientific excellence. We partner with  state-of-the-art, GMP-certified facilities and perform additional purity testing in independent Swiss laboratories, ensuring quality and safety in every batch.

Backed by Science

Our formulations are based on cutting-edge Longevity research. Led by Chief Science Officer Sophie Chabloz, our team collaborates with longevity experts from top institutions to create highly effective, science-backed products.

Transparent Ingredients

We carefully select the purest and most bioavailable plant extracts and compounds available. Our product descriptions clearly outline the production methods and origins of each ingredient.

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