4.8/5
SkinSpan™ System
SkinSpan™ System is the result of years of research into the ideal ingredient combination for skin longevity. Our researchers realised that while we fundamentally believe in delivering nutrients systemically as oral supplements, we can add additional efficacy by delivering selected compounds topically to the skin for a more complete approach to skin health - from inside and outside.
The SkinSpan system combines our Advanced Serum and Supplement capsules to counter skin ageing through 4 major levers:
- Accelerates skin cell renewal: Cellaigie™ peptides and PhytoCellTec™ Apple Stem cells accelerate skin cell renewal back to youthful levels
- Restores NAD⁺ levels: RejuveNAD™ boosts NAMPT to increase the skin’s own NAD⁺ production, countering natural decline
- Increases Collagen & Elastin production: PhytoCellTec™ Exosomes from Goji berries, enhances fibroblasts activity to stimulate fresh collagen and elastin production.
- Regenerates and strengthens skin barrier: Niacinamide, Hyaluronic acid and Beta-Glucan restore and strengthen the skin barrier, preventing moisture and collagen loss
While most skincare solutions focus on fighting symptoms and provide superficial remedies such as surface level only hydration, the SkinSpan™ System is designed to target the core biological root causes of skin ageing deep within the skin cells.
Manufactured in Switzerland
Based on cutting-edge research
Try without risk
90 days money back guarantee
The first skincare system combining topical and systemic components.
Accelerates Cellular Renewal
Our skin cells renew themselves continuously, unfortunately this process slows down dramatically with age, leading to older skin cells with dull, rough texture, and accumulated cellular waste. Cellaigie™, a peptide (serum) made from natural amino acids optimized using AI technology and PhytoCellTec™ Md Nu (capsules), a clinically studied plant stem cell extract, stimulate skin cells to focus on renewal. By reactivating cellular renewal we get fresher cells, resulting in smoother texture, renewed radiance, and visibly more youthful, resilient skin over time.
Restores Cellular Energy
With age, NAD⁺ levels decline sharply, reducing the energy skin cells need for repair and healthy renewal. The serum contains RejuveNAD™ - a bioactive extract derived from nutrient-rich sunflower sprouts and developed through precision biotechnology - that penetrates the skin and supports the cell’s own NAD⁺ production by upregulating key enzymes in the NAD+ Production. By boosting NAD+ levels directly in the skin, this longevity serum restores the energy of the skin cells to youthful levels, promoting faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin.
Increases Collagen & Elastin Production
Ageing and a weakening skin barrier naturally lead to a decline in the skin cells. Elastin and Collagen levels, key components for well moisturised and plump skin, PhytoCellTec™ Stem Cells from Swiss Apples (capsules) and Exosomes from Goji berry stem cells (serum), act as targeted cellular messengers, enhancing communication with specific skin cells, the fibroblasts, to stimulate fresh collagen and elastin production. This helps rebuild dermal density, reduce fine lines and wrinkles, and improve long-term structural resilience.
Strengthens & Protects the Skin Barrier
As the skin ages, the skin barrier becomes thinner and more reactive, resulting in dryness, irritation, increased transepidermal water and collagen loss. Therefore, any strategy to rejuvenate skin cells needs to include a reinforcement of the skin barrier to protect the achieved results. The serum combines Ectoin®, a natural molecule discovered in microorganisms that survive harsh desert and salt-lake environments with niacinamide and Beta-Glucan to rebuild and repair the skin barrier and protect the skin from environmental stress. The supplement capsules reinforce this effect with high-molecular weight Hyaluronic Acid with Ceramosides™, a patented complex of plant-derived ceramides, to deliver intensive hydration while strengthening the skin’s protective barrier.
The science behind longevity skincare.
Skin health basics
Most topical skincare products today are designed to temporarily fix the damage caused by exposure to sun, pollution, and the effects of ageing. This is mostly achieved by rehydrating the epidermis and forcing it to firm up in order to achieve temporary relief from dryness and fine lines. However, skin ageing begins not at the epidermis, but deep within the skin’s cells, where fundamental processes of repair, energy production, and communication gradually slow down. With age, skin cells experience:
- Slower cell renewal, leading to rough and damaged old skin cells and cellular waste to accumulate.
- A decline in cellular energy (ATP, NAD⁺), reducing the skin cells capacity to repair and regenerate.
- Reduced fibroblast activity, leading to decreased collagen and elastin production.
- A weakening skin barrier, causing moisture loss, irritation, and increased sensitivity.
- Greater vulnerability to environmental stressors such as UV exposure, pollution, and oxidative stress.
Traditional skincare products may mask these effects, but they cannot reactivate the underlying skin biology.
Our Longevity focused SkinSpan system takes a fundamentally different approach: instead of treating symptoms on the surface, it supports the cellular pathways that keep skin youthful. This includes accelerating cellular renewal, restoring cellular energy (ATP/NAD⁺), supporting fibroblast activity, strengthening the skin barrier, and protecting against oxidative stress.
By delivering synergetic ingredients from the inside through supplement capsules and topically via the serum from the outside we can achieve more complete support of the skin cells and more convincing results.
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Developed in collaboration with leading longevity scientists in Switzerland, SkinSpan™ Advanced Skin Serum applies the principles of cellular longevity directly to the skin, targeting the biological processes that drive ageing, rather than its visible symptoms.
Where most longevity-inspired serums focus on one aspect of skin ageing, such as antioxidant defence or collagen stimulation, SkinSpan™ Advanced Skin Serum works across four key biological pathways proven to influence how the skin functions and ages:
- Activates Cellular Renewal (Cellaigie™ Peptide): Cellaigie™ reactivates autophagy, the skin’s natural detox and renewal process, which slows dramatically with age. By clearing damaged proteins and improving renewal, it helps refine texture, boost elasticity, and restore radiance. Clinically shown to improve cell performance by up to 31% after 28 days.
- Restores Cellular Energy (RejuveNAD™): RejuveNAD™ supports the skin’s own NAD⁺ production by upregulating NAMPT - the rate-limiting enzyme in the NAD⁺ cycle. This boosts cellular energy needed for repair, collagen synthesis, and resilience against daily stressors. The result is visibly firmer, smoother, more energised skin over time.
- Rebuilds Collagen & Elastin (PhytoCellTec™ Exosomes + Beta-Glucan): PhytoCellTec™ Exosomes enhance fibroblast communication to stimulate collagen III, collagen XVI, and elastin production - essential for firmness and structural support. Beta-Glucan reinforces the extracellular matrix and supports repair, helping reduce fine lines and improve density. Skin appears firmer, smoother, and more resilient.
- Strengthens & Protects the Skin Barrier (Niacinamide, Ectoin®, Beta-Glucan, Betaine): Niacinamide, Ectoin, LMW Hyaluronic acid, Beta-Glucan, and plant-derived osmolytes strengthen the skin barrier and protect against environmental stress. This reduces sensitivity, improves moisture retention, and supports long-lasting hydration. The barrier becomes more stable, balanced, and resistant to irritation over time.
Unlike conventional or even other longevity-focused serums, SkinSpan™ Advanced Skin Serum doesn’t rely on a single “hero” ingredient. Its formulation reflects a systems biology approach to skin ageing, which is what allows results to compound over time.
- Activates Cellular Renewal (Cellaigie™ Peptide): Cellaigie™ reactivates autophagy, the skin’s natural detox and renewal process, which slows dramatically with age. By clearing damaged proteins and improving renewal, it helps refine texture, boost elasticity, and restore radiance. Clinically shown to improve cell performance by up to 31% after 28 days.
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We designed SkinSpan in collaboration with longevity researchers in Switzerland to support your skin’s ability to hydrate, repair, and renew itself from within, before visible signs of collagen decline appear.
Unlike traditional beauty blends, SkinSpan was designed with synergistic ingredients to work across multiple biological pathways:
For Deep Cellular Renewal:SkinSpan is powered by PhytoCellTec™ Md Nu, a clinically studied plant stem cell extract that helps restore skin stem cell vitality and accelerate epidermal regeneration. As the skin’s natural renewal cycle slows with age – from around 28 days to over 80 – this ingredient supports a more youthful turnover cycle, improving texture, tone, and overall skin vitality.
To further enhance renewal, SkinSpan includes Beta-Carotene, a natural precursor of Vitamin A. Once converted in the body, it gently stimulates cell turnover, encouraging the shedding of dull, older cells and revealing fresher, clearer skin beneath.
For Collagen Support:While our Collagen Activator provides the key building blocks for our bodies to produce collagen, SkinSpan™ complements this by enhancing the skin’s ability to maintain firmness, tone, and structural integrity.
It features a synergistic blend of DracoBelle™ Nu (a longevity flower extract that supports endogenous collagen production), Vitamin C, and Copper, key cofactors that stimulate collagen synthesis and help protect skin cells from oxidative stress.
For Skin Cell Protection:
SkinSpan™ helps defend against one of the most overlooked drivers of skin ageing: oxidative stress. Featuring Beta-Carotene and DracoBelle™ Nu, it provides targeted antioxidant support to help neutralise free radicals triggered by UV exposure, pollution, and everyday stressors. This protection helps preserve cellular integrity, reduce premature signs of ageing, and maintain a smoother, more radiant complexion over time.
The result of SkinSpan™ is a science-driven formula that doesn’t just add moisture - it enhances your skin’s own regenerative intelligence. Unlike conventional blends that focus on superficial hydration or isolated ingredients, every ingredient within SkinSpan™ has been carefully selected, precisely dosed, and clinically supported to work in synergy, thus promoting visible improvements in firmness, smoothness, and skin resilience over time.
For Skin Barrier Strength & Lasting Hydration:
The skin barrier is your first line of defence, but with age, it becomes thinner, more fragile, and less effective at retaining moisture or protecting against daily stressors. SkinSpan™ helps fortify this critical structure with Ceramosides™, a patented complex of plant-derived ceramides that strengthens the skin barrier and locks moisture in.
To complement this, 200mg of high molecular weight Hyaluronic Acid delivers deep hydration, restoring suppleness from within. This dual approach helps restore plumpness, reduce transepidermal water loss, and reinforce resilience against dryness and irritation.
CLINICALLY BACKED FORMULAS
Clinical studies on SkinSpan ingredients show:
81%
noticed that their skin felt smoother (PhytoCellTec™ Md Nu)115.3%
Crow’s feet wrinkle depth reduction after 42 days (RejuveNAD™)28.7%
increase in dermis thickness (DracoBelle™ Nu)314 days
to better skin quality & reduced wrinkle depth (CeramosidesTM)41. Baumann, Julia & Wandrey, Franziska & Nowak, Kathrin & Grothe, Torsten. (2024). Nutritional supplementation of an apple callus extract to target epidermal aging. Journal of Food, Nutrition and Diet Science. 18-28. 10.55976/fnds.22024123718-28 2. https://mibellebiochemistry.com/rejuvenadtm3. Baumann, Julia & Bönzli, Eva & Wandrey, Franziska & Grothe, Torsten. (2025). Moldavian Dragonhead Extract: A Natural Collagen-Booster to Target Skin Aging. OBM Geriatrics. 09. 1-22. 10.21926/obm.geriatr.2502305 4. Kern, C., Dudonné, S., & Garcia, C. (2024). Dietary supplementation with a wheat polar lipid complex improves skin conditions in women with dry skin and mild-to-moderate skin aging. Journal of cosmetic dermatology, 23(4), 1320–1330. https://doi.org/10.1111/jocd.16130
*Based on our customer survey; N = 450.
SkinSpan System™
1 x 30ml per bottle, 1 x 30 capsules per bottle (1-month supply)SkinSpan System™
1 x 30ml per bottle, 1 x 30 capsules per bottle (1-month supply)SkinSpan™ System is AVEA’s only synergetic combination of a supplement with a topical serum delivering highly effective ingredients to the skin, from the inside and outside. Developed with leading longevity scientists in Switzerland, it’s designed to offer the most complete solution to counter skin ageing.
It targets the four core biological drivers of skin ageing:
- Reduced skin cell renewal: Cellaigie™ peptides and PhytoCellTec™ Apple Stem cells accelerate skin cell renewal back to youthful levels
- Declining NAD⁺ levels: RejuveNAD™ boosts NAMPT to increase the skin’s own NAD⁺ production, countering natural decline
- Decreased Collagen & Elastin production: PhytoCellTec™ Exosomes from Goji berries, enhances fibroblast activity to stimulate fresh collagen and elastin production.
- Weakening skin barrier: Niacinamide, Hyaluronic acid and Beta-Glucan restore and strengthen the skin barrier, preventing moisture and collagen loss
This comprehensive approach to skin ageing from the inside and outside offers a more comprehensive and effective way to maintain firmness, smoothness, and overall skin health for the long run.
Use the serum morning and night on damp skin. Face, neck, decollete and take one supplement capsule a day with food, ideally lunch.
SERUM INGREDIENTS: Aqua (Water), Glycerin, Dimethicone, Diglycerin, Niacinamide, Betaine, Dipentaerythrityl Hexacaprylate/Hexacaprate, Ectoin, Maltodextrin, 1,2-Hexanediol, Caprylyl Methicone, Sodium Acrylates Copolymer, Hydroxyacetophenone, Cetearyl Dimethicone Crosspolymer, Isomalt, Lecithin, Polyacrylate Crosspolymer-6, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Hyaluronate, Tetrasodium Glutamate Diacetate, Potassium Chloride, Sodium Carboxymethyl Beta-Glucan, Helianthus Annuus (Sunflower) Sprout Extract, Sorbitan Isostearate, Caprylyl Glycol, Lycium Barbarum Callus Culture Extract, Acetyl Tetrapeptide-2
SUPPLEMENT CAPSULE INGREDIENTS: Hyaluronic Acid 200 mg, Moldavian Dragonhead Extract (DracoBelle™ Nu) 200 mg, Vitamin C 80 mg, Wheat Seed Extract (Ceramosides™) 30 mg, Niacin (Vitamin B3) 16 mg, PhytoCellTecTM Md Nu 10 mg corresponds to Apple Fruit Cell Culture Biomass 0.15 mg, Beta Carotene 4.8 mg corresponds to Vitamin A 800 μg RE, Riboflavin (Vitamin B2) 1.4 mg, Copper 1 mg, Biotin 50 μg
Microcrystalline cellulose as bulking agent to ensure the capsule is completely full (active ingredients may not take up enough space), aiding in consistent manufacturing and dosing
Magnesium salts of fatty acids as anti-caking agent to ensure that powdered contents remain free-flowing (important for manufacturing) and to help achieve a consistent mixture of ingredients within the capsule (ensuring proper dosage)
Hydroxypropyl methyl cellulose (HPMC) as glazing agent in form of a vegetable capsule shell
Worldwide shipping, free shipping on orders over £50/€50/CHF50, 3-5 day average delivery time.
SkinSpan System™
Clean, transparent ingredients backed by science.
Formulated with traceable, clinically studied ingredients. Developed and manufactured in Switzerland.
RejuveNAD™
Derived from sustainably cultivated organic sunflower sprouts, RejuveNAD™ is a clinically studied plant-based ingredient that naturally boosts the levels of NAD⁺, the key molecule for cellular energy by enhancing the expression of the rate-limiting enzyme NAMPT. Restored NAD+ levels means that your cells' powerplants, the mitochondria, have more energy to repair, counteract aging-induced epigenetic alterations, and suppress the formation of senescent “zombie” cells. By supporting cellular energy, RejuveNAD™ helps restore your skin’s cells energy level to a youthful state and therefore promotes healthy skin on a holistic level.
Ceramosides™
Concentrated gluten free phytoceramides extracted from wheat that help rebuild the skin’s natural lipid barrier, locking in moisture and protecting against external irritants. They improve skin smoothness, hydration, and elasticity – clinically shown to reduce fine lines and dryness.
Hyaluronic Acid
A deeply hydrating molecule naturally occurring in the human body that can bind up to 1,000 times its weight in water. It helps visibly plump the skin, smooth the appearance of fine lines, and maintain optimal moisture levels – leaving the complexion softer, smoother, and more radiant.
PhytoCellTec™ Md Nu
A patented plant stem cell extract derived from a rare Swiss apple variety. It helps protect human skin stem cells, support cellular renewal, and delay signs of skin ageing – contributing to smoother, firmer, and more youthful skin³.
Niacinamide
Niacinamide, a form of vitamin B3, is a clinically studied ingredient that supports skin barrier function, enhances cellular energy, and promotes skin renewal. It helps reduce redness, improves uneven skin tone, and strengthens the skin’s natural defenses against environmental stress.
Cellaigie™
Cellaigie™ is a biomimetic peptide made from the same natural amino acids found in your skin that was optimized using AI technology to work in harmony with your body's cellular intelligence. It enhances autophagic activity, triggers cellular clearance, optimizes energy through glycophagy, and reduces markers of cellular senescence. By prioritizing skin cell renewal and efficiency, it supports firmer, more resilient, and radiant skin.
PhytoCellTec™ Exosomes
Exosomes are tiny packets that cells use to communicate with each other. They transport important information and signals from one cell to the next. This helps the body repair tissue, reduce inflammation and guide healing processes. PhytoCellTec exosomes are derived from goji berries and stimulate the release of the skin’s own stem cell exosomes. This boosts the production of collagen III, collagen XVI and elastin and strengthens the extracellular matrix, resulting in firmer, more youthful-looking skin.
DracoBelle™ Nu
Also known as Moldavian Dragonhead Extract, this clinically studied plant compound boosts cellular stress resistance and stimulates collagen production⁴. It also activates key cellular longevity pathways (like AMPK and FOXO), which support skin firmness and elasticity⁵.
Timeline of expected benefits
SkinSpan™ System was designed by applying the most the latest insights from longevity science on skin ageing. The combination of the supplement capsules and the serum provide the skin with a synergetic combination of nutrients from the inside and outside. Improvements occur progressively as the skin cell’s renewal rate accelerates, repair efficiency is restored and the skin barriers strengthens.
Improved hydration & smoother texture
During the first weeks, increased hydration and enhanced barrier function are typically the earliest observable changes. As the skin retains moisture more effectively, dryness and roughness begin to diminish. Early improvements in smoothness and suppleness may become noticeable as cellular turnover and repair processes are supported.
Enhanced firmness and resilience
With continued use, the pathways involved in collagen production, autophagy, and barrier reinforcement become more active. This can lead to visible softening of fine lines, improved elasticity, and a more even texture. The skin may also show greater resilience to environmental stressors as barrier integrity and cellular repair efficiency improve.
Measurable improvements in structure and radiance
Clinical data on the active ingredients indicate that longer-term use can lead to measurable changes, including reductions in wrinkle depth (up to ~16% in studies on key active ingredients), improvements in firmness and elasticity (around 8–12%), and increases in luminosity. Skin often appears more balanced, hydrated, and structurally supported, reflecting deeper improvements in the biological processes that influence ageing.
Why choose AVEA?
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Most anti-ageing serums target symptoms of ageing - dryness, fine lines, or loss of elasticity by stimulating or hydrating the skin. SkinSpan™ Advanced Skin Serum is built on cellular longevity science, designed to restore the fundamental biological processes that slow with age.
While many “longevity” formulas rely on a single mechanism (e.g., NAD⁺ boosters or peptides), SkinSpan™ Advanced Skin Serum integrates four proven pathways - cellular energy & renewal, collagen & elastin support, skin barrier defence & hydration. This systems-biology approach helps optimise how the skin generates energy, clears damage, and maintains structural integrity, rather than simply treating what’s visible at the surface.
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When we say SkinSpan™ Advanced Skin Serum is based on longevity science, we mean that its formulation is built on the same biological principles used in cellular longevity research, i.e. the field that studies why cells age, how they lose function, and how we can maintain their performance over time.
In the context of skincare, it means that rather than temporarily addressing surface symptoms (e.g. hydrating the epidermis, exfoliating, temporarily tightening the skin, etc.) like most traditional skincare solutions , longevity skincare formulas are instead optimised to support long-term skin cellular health.
We designed SkinSpan™ Advanced Skin Serum to apply the core longevity principles we have in our supplements directly to the skin, using clinically studied ingredients that reactivate cellular energy metabolism (RejuveNAD™), promote cellular recycling (Cellaigie™), and enhance fibroblast signalling (PhytoCellTec™ Exosomes) to further enhance the effects of your supplementation routine for a more complete inside-out approach to skin longevity.
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NAD⁺ and autophagy are two fundamental pillars of cellular function that determine how effectively the skin repairs damage, produces collagen, and resists visible ageing.
NAD⁺ (nicotinamide adenine dinucleotide) is a molecule every cell needs to produce energy, repair DNA, and maintain healthy function. But NAD⁺ levels decline sharply with age, including in skin cells. When NAD⁺ drops:
- Collagen production slows
- Repair mechanisms become less efficient
- Skin becomes thinner, duller, and more prone to damage
- Environmental stress (UV, pollution) causes more harm
Supporting NAD⁺ metabolism helps skin cells regain the energy required for repair, renewal, and healthy collagen synthesis, all of which directly influence firmness, elasticity, and skin resilience. In SkinSpan™ serum, this is addressed through RejuveNAD™, which helps activate the skin’s natural NAD⁺ cycle.
Autophagy is the process through which cells “clean out” damaged proteins and waste so they can function optimally. As autophagy slows with age:
- Cellular waste accumulates
- Texture becomes rough and uneven
- Radiance declines
- Skin loses its ability to regenerate efficiently
Reactivating autophagy essentially tells skin cells to renew themselves, improving smoothness, clarity, and overall vitality. SkinSpan™ serum supports this with Cellaigie™, a peptide that encourages a renewal-focused state similar to the benefits seen in cellular detox pathways.
Together, NAD⁺ and autophagy determine how well skin cells can:
- Repair daily damage
- Stay energized
- Produce collagen and elastin
- Maintain an even, healthy texture
- Resist environmental stressors
When both pathways decline (which naturally happens with age), visible aging accelerates. When both are supported, skin can behave more like it does in its younger years, renewing faster, repairing better, and maintaining healthier structure over time. This effect is further enhanced by supporting the skin with oral supplementation for a more complete inside-out approach.
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Apply one to two pumps of the serum to clean, dump skin twice daily - morning and evening.
Gently press into the face, neck, and décolletage until absorbed. Use before moisturizer or sunscreen during the day, and before your night cream in the evening. Pair with one supplement capsule a day with food, preferably for breakfast.
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A pea-sized amount (one pump) is sufficient for the entire face. The serum is highly concentrated - our formulation comprises clinically studied active ingredients - so using more does not enhance results. Consistency, not quantity, drives the best results.
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Both parts of the SkinSpan™ System were developed and manufactured in Switzerland under GMP-certified conditions.
The formulation was created in collaboration with leading longevity scientists to ensure precision, stability, and bioavailability of each active compound. Each ingredient is sourced from traceable suppliers with clinical validation and tested for purity and safety.
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Yes, they are designed to work synergistically.
SkinSpan™ targets the skin’s surface and cellular interface - restoring NAD⁺, autophagy and cell renewal.
The Collagen Activator supplies the molecular building blocks and cofactors needed for new collagen synthesis,
Together, they reinforce each other’s pathways, creating a closed-loop system that supports skin structure, moisture, and biological longevity across all layers.
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At AVEA, every formulation begins with a deep understanding of the biological processes that drive ageing – and how we can influence them. Our work is grounded in the latest findings from the fields of cellular health, metabolic and longevity science.
Led by our Co-Founder and Chief Science Officer, Sophie Chabloz, our in-house science team partners with world-class longevity researchers and biotech experts from leading academic institutions. Together, we translate complex, peer-reviewed research into targeted, effective supplement formulas designed to support cellular function, resilience, and long-term vitality.
Each supplement we create is based on clinically studied ingredients, optimised for bioavailability, and rigorously tested – so that what works in the lab also works in your daily life.
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Your supplements will be dispatched from our UK warehouse within 24 hours.
We ship internationally and offer a variety of shipping options:
Standard shipping is free for orders over £50 and is sent via local postal services. For faster delivery, we also offer express options via commercial carriers, depending on your destination.All available shipping methods – along with estimated delivery times and final costs – will be displayed during checkout.
If your country isn’t listed at checkout, feel free to contact our customer service team at support@avea-life.com, and we’ll be happy to explore possible solutions.
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The full benefits of skincare cosmetics take time to develop. Many customers notice initial improvements within the first month, while the full effect typically unfolds after 2–3 months. Since everyone is unique, results may vary. That’s why we recommend following your new routine for at least 3 months.
If you’re not satisfied after this period, you can make use of our 90-day money-back guarantee.
Frequently asked questions