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SkinSpan™ Advanced Skin Serum | A next-generation Swiss serum | AVEA
THIS WEEK ONLY
Up to 25% off, PLUS extra savings when you spend: 100 € for an EXTRA 10% off, 150 € for an EXTRA 15% off, 200 € for an EXTRA 20% off.
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4.8/5 1208 reviews
SkinSpan™ Advanced Skin Serum
SkinSpan™ Advanced Skin Serum is the result of our effort to develop the most effective solution to skin ageing. While developing our best-selling longevity supplements, it became clear that we could further optimise results by delivering selected compounds directly to the skin. Our only serum formula is designed to function as a supplement consumed through the skin and work alongside other orally consumed longevity supplements for a more complete approach to skin health - from inside and outside.
SkinSpan™ Advanced Skin Serum has been designed to target the four core biological drivers of skin ageing:
Declining NAD⁺: RejuveNAD™ boosts NAMPT to increase the skin’s own NAD⁺ production, restoring cellular energy and repair.
Reduced Autophagy: Cellaigie™ reactivates cellular clean-up to clear damaged proteins and accelerate skin cell renewal.
Collagen & Elastin Loss: PhytoCellTec™ Exosomes enhance fibroblast communication, stimulating collagen III, XVI and elastin for improved firmness.
Barrier Weakening: Niacinamide, Ectoin®, Beta-Glucan, Betaine and Diglycerin strengthen the skin barrier, reduce transepidermal water loss, and soothe inflammation.
While conventional serums focus only on surface hydration, SkinSpan™ Advanced Skin Serum is designed to target the four core biological root causes of skin ageing deep within the skin cells all in one formula.
The first face serum powered by true longevity science.
Developed in Switzerland and designed to complement our oral longevity formulations, SkinSpan™ Advanced Skin Serum combines NAD⁺ activation, autophagy stimulation, exosome-driven collagen renewal, and advanced skin-barrier repair to counteract the root causes of visible ageing and support long-term skin regeneration.
With age, NAD⁺ levels decline sharply, reducing the energy skin cells need for repair and healthy renewal. RejuveNAD™ - a bioactive extract derived from nutrient-rich sunflower sprouts and developed through precision biotechnology - supports the skin’s own NAD⁺ production by upregulating NAMPT, the rate-limiting enzyme in the NAD⁺ biosynthesis pathway. By boosting NAD+ levels directly in the skin, this longevity serum restores the energy of the skin cells to youthful levels faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin.
With age, NAD⁺ levels decline sharply, reducing the energy skin cells need for repair and healthy renewal. RejuveNAD™ - a bioactive extract derived from nutrient-rich sunflower sprouts and developed through precision biotechnology - supports the skin’s own NAD⁺ production by upregulating NAMPT, the rate-limiting enzyme in the NAD⁺ biosynthesis pathway. By boosting NAD+ levels directly in the skin, this longevity serum restores the energy of the skin cells to youthful levels faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin.
Autophagy - the cell’s natural renewal and detoxification system - slows dramatically with age, leading to older skin cells with dull, rough texture, and accumulated cellular waste. Cellaigie™ is a biomimetic peptide made from the same natural amino acids found in your skin that was optimized using AI technology. It targets mTOR, a central regulator for cell growth, stimulating skin cells to focus on renewal, similar to the benefits of cellular fasting. By reactivating autophagy pathways, it accelerates the clearance of damaged components and restores efficient cellular renewal. The result is smoother texture, renewed radiance, and visibly more youthful, resilient skin over time.
Autophagy - the cell’s natural renewal and detoxification system - slows dramatically with age, leading to older skin cells with dull, rough texture, and accumulated cellular waste. Cellaigie™ is a biomimetic peptide made from the same natural amino acids found in your skin that was optimized using AI technology. It targets mTOR, a central regulator for cell growth, stimulating skin cells to focus on renewal, similar to the benefits of cellular fasting. By reactivating autophagy pathways, it accelerates the clearance of damaged components and restores efficient cellular renewal. The result is smoother texture, renewed radiance, and visibly more youthful, resilient skin over time.
Restores Cellular Energy
With age, NAD⁺ levels decline sharply, reducing the energy skin cells need for repair and healthy renewal. RejuveNAD™ - a bioactive extract derived from nutrient-rich sunflower sprouts and developed through precision biotechnology - supports the skin’s own NAD⁺ production by upregulating NAMPT, the rate-limiting enzyme in the NAD⁺ biosynthesis pathway. By boosting NAD+ levels directly in the skin, this longevity serum restores the energy of the skin cells to youthful levels faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin.
Activates Cellular Renewal
Autophagy - the cell’s natural renewal and detoxification system - slows dramatically with age, leading to older skin cells with dull, rough texture, and accumulated cellular waste. Cellaigie™ is a biomimetic peptide made from the same natural amino acids found in your skin that was optimized using AI technology. It targets mTOR, a central regulator for cell growth, stimulating skin cells to focus on renewal, similar to the benefits of cellular fasting. By reactivating autophagy pathways, it accelerates the clearance of damaged components and restores efficient cellular renewal. The result is smoother texture, renewed radiance, and visibly more youthful, resilient skin over time.
Increases Collagen & Elastin production
Ageing reduces the skin’s production of collagen III, collagen XVI, and elastin - key fibres responsible for firmness, elasticity, and structural support. PhytoCellTec™ Exosomes, derived from Goji berry stem cells, act as targeted cellular messengers, enhancing communication with specific skin cells, the fibroblasts, to stimulate fresh collagen and elastin production. This helps rebuild dermal density, reduce fine lines and wrinkles, and improve long-term structural resilience. As the serum increases the collagen production in fibroblasts, its effectiveness can be further enhanced with our Collagen Activator which ensures the body is supplied with the right amount and the optimised form of the building blocks, e.g. amino acids, needed for new collagen formation.
Strengthens & Protects the Skin Barrier
As the skin ages, the skin barrier becomes thinner and more reactive, resulting in dryness, irritation, increased transepidermal water loss (TEWL), and heightened sensitivity. Therefore, any strategy to rejuvenate skin cells needs to include a reinforcement of the skin barrier to protect the achieved results. In our serum niacinamide, a bioactive form of Vitamin B3, boosts ceramides and essential lipids to rebuild barrier integrity. Ectoin®, discovered in microorganisms that survive harsh desert and salt-lake environments, stabilises cellular structures and protects the skin under environmental stress. Beta-Glucan, naturally derived from yeast, soothes irritation and supports extracellular matrix repair.
Increases Collagen & Elastin productionStrengthens & Protects the Skin Barrier
Ageing reduces the skin’s production of collagen III, collagen XVI, and elastin - key fibres responsible for firmness, elasticity, and structural support. PhytoCellTec™ Exosomes, derived from Goji berry stem cells, act as targeted cellular messengers, enhancing communication with specific skin cells, the fibroblasts, to stimulate fresh collagen and elastin production. This helps rebuild dermal density, reduce fine lines and wrinkles, and improve long-term structural resilience. As the serum increases the collagen production in fibroblasts, its effectiveness can be further enhanced with our Collagen Activator which ensures the body is supplied with the right amount and the optimised form of the building blocks, e.g. amino acids, needed for new collagen formation.
Ageing reduces the skin’s production of collagen III, collagen XVI, and elastin - key fibres responsible for firmness, elasticity, and structural support. PhytoCellTec™ Exosomes, derived from Goji berry stem cells, act as targeted cellular messengers, enhancing communication with specific skin cells, the fibroblasts, to stimulate fresh collagen and elastin production. This helps rebuild dermal density, reduce fine lines and wrinkles, and improve long-term structural resilience. As the serum increases the collagen production in fibroblasts, its effectiveness can be further enhanced with our Collagen Activator which ensures the body is supplied with the right amount and the optimised form of the building blocks, e.g. amino acids, needed for new collagen formation.
As the skin ages, the skin barrier becomes thinner and more reactive, resulting in dryness, irritation, increased transepidermal water loss (TEWL), and heightened sensitivity. Therefore, any strategy to rejuvenate skin cells needs to include a reinforcement of the skin barrier to protect the achieved results. In our serum niacinamide, a bioactive form of Vitamin B3, boosts ceramides and essential lipids to rebuild barrier integrity. Ectoin®, discovered in microorganisms that survive harsh desert and salt-lake environments, stabilises cellular structures and protects the skin under environmental stress. Beta-Glucan, naturally derived from yeast, soothes irritation and supports extracellular matrix repair.
As the skin ages, the skin barrier becomes thinner and more reactive, resulting in dryness, irritation, increased transepidermal water loss (TEWL), and heightened sensitivity. Therefore, any strategy to rejuvenate skin cells needs to include a reinforcement of the skin barrier to protect the achieved results. In our serum niacinamide, a bioactive form of Vitamin B3, boosts ceramides and essential lipids to rebuild barrier integrity. Ectoin®, discovered in microorganisms that survive harsh desert and salt-lake environments, stabilises cellular structures and protects the skin under environmental stress. Beta-Glucan, naturally derived from yeast, soothes irritation and supports extracellular matrix repair.
Restores Cellular Energy
With age, NAD⁺ levels decline sharply, reducing the energy skin cells need for repair and healthy renewal. RejuveNAD™ - a bioactive extract derived from nutrient-rich sunflower sprouts and developed through precision biotechnology - supports the skin’s own NAD⁺ production by upregulating NAMPT, the rate-limiting enzyme in the NAD⁺ biosynthesis pathway. By boosting NAD+ levels directly in the skin, this longevity serum restores the energy of the skin cells to youthful levels faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin.
Activates Cellular Renewal
Autophagy - the cell’s natural renewal and detoxification system - slows dramatically with age, leading to older skin cells with dull, rough texture, and accumulated cellular waste. Cellaigie™ is a biomimetic peptide made from the same natural amino acids found in your skin that was optimized using AI technology. It targets mTOR, a central regulator for cell growth, stimulating skin cells to focus on renewal, similar to the benefits of cellular fasting. By reactivating autophagy pathways, it accelerates the clearance of damaged components and restores efficient cellular renewal. The result is smoother texture, renewed radiance, and visibly more youthful, resilient skin over time.
Increases Collagen & Elastin production
Ageing reduces the skin’s production of collagen III, collagen XVI, and elastin - key fibres responsible for firmness, elasticity, and structural support. PhytoCellTec™ Exosomes, derived from Goji berry stem cells, act as targeted cellular messengers, enhancing communication with specific skin cells, the fibroblasts, to stimulate fresh collagen and elastin production. This helps rebuild dermal density, reduce fine lines and wrinkles, and improve long-term structural resilience. As the serum increases the collagen production in fibroblasts, its effectiveness can be further enhanced with our Collagen Activator which ensures the body is supplied with the right amount and the optimised form of the building blocks, e.g. amino acids, needed for new collagen formation.
Strengthens & Protects the Skin Barrier
As the skin ages, the skin barrier becomes thinner and more reactive, resulting in dryness, irritation, increased transepidermal water loss (TEWL), and heightened sensitivity. Therefore, any strategy to rejuvenate skin cells needs to include a reinforcement of the skin barrier to protect the achieved results. In our serum niacinamide, a bioactive form of Vitamin B3, boosts ceramides and essential lipids to rebuild barrier integrity. Ectoin®, discovered in microorganisms that survive harsh desert and salt-lake environments, stabilises cellular structures and protects the skin under environmental stress. Beta-Glucan, naturally derived from yeast, soothes irritation and supports extracellular matrix repair.
Clean, transparent ingredients backed by science
Formulated with traceable, clinically studied ingredients. Developed in Switzerland.
RejuveNAD™
Derived from sustainably cultivated organic sunflower sprouts, RejuveNAD™ is a clinically studied plant-based ingredient that naturally boosts the levels of NAD⁺, the key molecule for cellular energy by enhancing the expression of the rate-limiting enzyme NAMPT. By boosting NAMPT, RejuveNAD™ allows skin cells to naturally generate more NAD⁺, supporting faster repair, stronger resilience to environmental stress, and visibly firmer, smoother, more energised skin over time.
Niacinamide
Niacinamide, a form of vitamin B3, is a clinically studied ingredient that supports skin barrier function, enhances cellular energy, and promotes skin renewal. It helps reduce redness, improves uneven skin tone, and strengthens the skin’s natural defenses against environmental stress.
Cellaigie™
Cellaigie™ is a biomimetic peptide made from the same natural amino acids found in your skin that was optimized using AI technology to work in harmony with your body's cellular intelligence. It enhances autophagic activity, triggers cellular clearance, optimizes energy through glycophagy, and reduces markers of cellular senescence. By prioritizing skin cell renewal and efficiency, it supports firmer, more resilient, and radiant skin.
PhytoCellTec™ Exosomes
Exosomes are tiny packets that cells use to communicate with each other. They transport important information and signals from one cell to the next. This helps the body repair tissue, reduce inflammation and guide healing processes. PhytoCellTec exosomes are derived from goji berries and stimulate the release of the skin’s own stem cell exosomes. This boosts the production of collagen III, collagen XVI and elastin and strengthens the extracellular matrix, resulting in firmer, more youthful-looking skin.
Ectoin
A stress-protective compound produced by microorganisms that thrive in extreme environments. It stabilizes cell membranes, preserves protein structure, and reduces oxidative damage, supporting skin barrier integrity, resilience, and long-lasting hydration.
Low Molecular Weight Hyaluronic Acid
A smaller, more penetrative form of the skin's natural moisture molecule. Unlike traditional hyaluronic acid that sits on the surface, its reduced molecular size allows it to travel deeper into the skin layers, delivering hydration where it's needed most. By attracting and binding up to 1000 times its weight in water, it plumps the skin, smooths fine lines, and supports the skin's structural matrix for a fuller, more youthful appearance with long-lasting moisture retention.
Betaine
A natural osmolyte (water-attracting molecule) derived from sugar beets, found naturally in skin and throughout nature. It acts as a cellular water manager, attracting and holding moisture while protecting proteins from damage. By maintaining optimal hydration balance and strengthening the skin barrier, betaine ensures skin stays resilient, comfortable, and moisturized even under environmental stress.
Beta Glucan
A protective polysaccharide extracted from baker's yeast that activates the skin's natural repair and defense systems. By communicating with immune cells in the skin, it stimulates healing processes, accelerates recovery from stress and damage, and strengthens the skin barrier. This "repair and defense molecule" reduces inflammation, locks in moisture, and enhances skin resilience.
Diglycerin
A humectant derived from glycerin that provides superior moisture-binding capacity with enhanced skin compatibility. Its dual glycerin structure allows it to penetrate more effectively while attracting and retaining water in the skin, creating a reservoir of hydration that lasts. Unlike simple glycerin, diglycerin offers a lighter, more elegant feel while delivering deep, sustained moisture that supports skin barrier function and maintains optimal hydration levels throughout the day.
Developed in Switzerland
Formulated by experts
Sustainable Packaging
Clinically proven results
Vegan
New
Skinspan™ Advanced Skin Serum
30 ml per bottle
New
4.6/5 (600+ reviews)
Skinspan™ Advanced Skin Serum
30 ml per bottle
£83.00Sale•
Save
SkinSpan™ Advanced Skin Serum is AVEA’s only serum formulation delivering key ingredients directly to the skin. Developed with leading longevity scientists in Switzerland, it’s designed to complement our oral formulations and target the same core cellular mechanisms directly via absorption into the skin.
It targets the four core biological drivers of skin ageing:
Declining NAD⁺: Declining NAD⁺: RejuveNAD™ boosts the skin’s own NAD⁺ production, restoring cellular energy for repair, and renewal.
Reduced Autophagy: Cellaigie™ reactivates cellular clean-up pathways to clear damaged proteins and accelerate skin cell renewal.
Collagen & Elastin Loss: PhytoCellTec™ Exosomes stimulate the skin cells’ collagen and elastin production for improved firmness.
Barrier Weakening: Niacinamide, Ectoin, LMW Hyaluronic acid, Beta-Glucan, Betaine and Diglycerin strengthen the skin barrier, reduce transepidermal water loss, and soothe inflammation.
SkinSpan™ Advanced Skin Serum supports the same longevity pathways as our supplements with direct delivery to your skin cells where ageing is most visible.
When used together with AVEA’s oral formulations even stronger effects can be achieved as the supplements work internally, providing the nutrients and precursors your body needs to build collagen, repair cells, and strengthen the skin barrier and the serum then complements this externally by boosting cellular energy (NAD⁺), activating renewal (autophagy), stimulating collagen and elastin production directly in the skin cells.
This comprehensive approach to skin ageing from the inside and outside offers a more comprehensive and effective way to maintain firmness, smoothness, and overall skin health for the long run.
90 days money-back guarantee
Use morning and night on damp skin. Face, neck, decollete.
Worldwide shipping, free shipping on orders over £50/€50/CHF50, 3-5 day average delivery time.
Skinspan™ Advanced Skin Serum
A longevity-powered serum that boosts NAD⁺, activates renewal, and restores collagen for improved skin health.
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The science behind longevity skincare.
Skin Health Basics
Most topical skincare products today are designed to temporarily fix the damage caused by exposure to sun, pollution, and the effects of ageing. This is mostly achieved by rehydrating the epidermis and forcing it to firm up in order to achieve temporary relief from dryness and fine lines. However, skin ageing begins not at the epidermis, but deep within the skin’s cells, where fundamental processes of repair, energy production, and communication gradually slow down. With age, skin cells experience:
A decline in cellular energy (ATP, NAD⁺), reducing their capacity to repair and regenerate.
Slower autophagy, allowing damaged proteins and cellular waste to accumulate.
Reduced fibroblast activity, leading to decreased collagen and elastin synthesis.
A weakening skin barrier, causing moisture loss, irritation, and increased sensitivity.
Greater vulnerability to environmental stressors such as UV exposure, pollution, and oxidative stress.
Traditional skincare products may mask these effects, but they cannot reactivate the underlying skin biology.
Our Longevity skincare takes a fundamentally different approach: instead of treating symptoms on the surface, it supports the cellular pathways that keep skin youthful. This includes restoring cellular energy (ATP/NAD⁺), reactivating autophagy, supporting fibroblast communication, strengthening the skin barrier, and protecting against oxidative and glycation stress.
By optimising these longevity pathways, the skin can naturally produce more collagen and elastin, repair damage more efficiently, maintain hydration, and stay more resilient over time. These results are further compounded when combined with oral supplementation for a more inside-out approach to skin health.
Developed in collaboration with leading longevity scientists in Switzerland, SkinSpan™ Advanced Skin Serum applies the principles of cellular longevity directly to the skin, targeting the biological processes that drive ageing, rather than its visible symptoms.
Where most longevity-inspired serums focus on one aspect of skin ageing, such as antioxidant defence or collagen stimulation, SkinSpan™ Advanced Skin Serum works across four key biological pathways proven to influence how the skin functions and ages:
Restores Cellular Energy (RejuveNAD™): RejuveNAD™ supports the skin’s own NAD⁺ production by upregulating NAMPT - the rate-limiting enzyme in the NAD⁺ cycle. This boosts cellular energy needed for repair, collagen synthesis, and resilience against daily stressors. The result is visibly firmer, smoother, more energised skin over time.
Activates Cellular Renewal (Cellaigie™ Peptide): Cellaigie™ reactivates autophagy, the skin’s natural detox and renewal process, which slows dramatically with age. By clearing damaged proteins and improving renewal, it helps refine texture, boost elasticity, and restore radiance. Clinically shown to improve cell performance by up to 31% after 28 days.
Rebuilds Collagen & Elastin (PhytoCellTec™ Exosomes + Beta-Glucan): PhytoCellTec™ Exosomes enhance fibroblast communication to stimulate collagen III, collagen XVI, and elastin production - essential for firmness and structural support. Beta-Glucan reinforces the extracellular matrix and supports repair, helping reduce fine lines and improve density. Skin appears firmer, smoother, and more resilient.
Strengthens & Protects the Skin Barrier (Niacinamide, Ectoin®, Beta-Glucan, Betaine): Niacinamide, Ectoin®, LMW Hyaluronic acid, Beta-Glucan, and plant-derived osmolytes strengthen the skin barrier and protect against environmental stress. This reduces sensitivity, improves moisture retention, and supports long-lasting hydration. The barrier becomes more stable, balanced, and resistant to irritation over time.
Unlike conventional or even other longevity-focused serums, SkinSpan™ Advanced Skin Serum doesn’t rely on a single “hero” ingredient. Its formulation reflects a systems biology approach to skin ageing, which is what allows results to compound over time.
From a scientific perspective, skin ageing is influenced by both internal and external processes:
Internally: The body gets worse in converting nutrients into the essential materials needed to maintain youthful, firm and hydrated skin such as collagen, elastin and ceramides.
Externally: Exposure to oxidative stress and the environment lowers the cells' energy and weakens the skin barrier, making signs of ageing more visible.
Our best selling Collagen Activator features Colgevity™, a patented, 100% vegan collagen precursor complex to provide the body with specifically optimised building blocks for collagen synthesis, leading to higher and more efficient collagen production in the whole body.
Our SkinSpan™ Advanced Skin Serum acts directly on skin cells, supporting NAD⁺ restoration for more cell energy and cellular renewal, as well as further stimulating the skin cells’ own collagen & elastin production. Our SkinSpan™ Supplement, on the other hand, delivers Hyaluronic Acid, Ceramosides™, and PhytoCellTec™ Md Nu to improve hydration and then strengthen the skin barrier of the renewed cells.
Used all together, you have the most complete inside-out approach to skin health.
Feel the dıfference
Clinical studies on SkinSpan™ Advanced Skin Serum:
31%
reduction in in visible wrinkle count in 4 weeks — measured by VISIA imaging.*
29%
improvement in skin elasticity after 4 weeks.*
19.4%
reduction in transepidermal water loss — measured within 30 minutes of first application.*
21%
increase in skin moisture levels — measured within 30 minutes of first application.*
We designed SkinSpan™ Advanced Skin Serum to apply the core longevity principles we have in our supplements directly to the skin, using clinically studied ingredients that reactivate cellular energy metabolism (RejuveNAD™), promote cellular recycling (Cellaigie™), and enhance fibroblast signalling (PhytoCellTec™ Exosomes) to further enhance the effects of your supplementation routine. Deeper improvements tend to occur progressively as the skin’s repair efficiency is restored over time
1. MONTH
Improved hydration & smoother texture
During the first weeks, increased hydration and enhanced barrier function are typically the earliest observable changes. As the skin retains moisture more effectively, dryness and roughness begin to diminish. Early improvements in smoothness and suppleness may become noticeable as cellular turnover and repair processes are supported.
2. MONTHS
Enhanced firmness and resilience
With continued use, the pathways involved in collagen production, autophagy, and barrier reinforcement become more active. This can lead to visible softening of fine lines, improved elasticity, and a more even texture. The skin may also show greater resilience to environmental stressors as barrier integrity and cellular repair efficiency improve.
3. MONTHS
Measurable improvements in structure and radiance
Clinical data on the active ingredients indicate that longer-term use can lead to measurable changes, including reductions in wrinkle depth (up to ~16% in studies on key active ingredients), improvements in firmness and elasticity (around 8–12%), and increases in luminosity. Skin often appears more balanced, hydrated, and structurally supported, reflecting deeper improvements in the biological processes that influence ageing.
*Based on customer surveys and scientific literature. Results may vary
More than 100.000 happy AVEA customers
Here is what they love about SkinSpan™ Advanced Skin Serum:
Customer Reviews
Overall rating: 4.7 / 5 from 67 reviews.
Das ist jetzt mein drittes Mal, dass ich es Kind Spam bestelle und ich bin damit sehr zufrieden. Meiner Haut tut es gut es ist sehr angenehmes Gel, was da einfach aufzutragen ist zieht direkt ein und ich habe auf jeden Fall das Gefühl, dass meine Haut glatter geworden ist! Von mir gibt es eine ganz klare Empfehlung👍
Store owner replied:
Vielen Dank für deine tolle Bewertung! Dreimal nachbestellt — das ist das schönste Kompliment! Es freut uns riesig, dass du sichtbare Ergebnisse spürst und das Auftragen so angenehm findest. Danke für die klare Empfehlung und dein Vertrauen in AVEA!
Danke, dass ich zunächst eine Probepackung von Avea Skinspan erhalten habe. Ehrlich gesagt war ich anfangs skeptisch – ich dachte mir: „Ich probiere das einfach mal aus.“
Doch schon nach der ersten Packung war ich so überzeugt, dass ich direkt nachbestellt habe. Und was soll ich sagen: Inzwischen werde ich ständig von meinen Kollegen gefragt, was ich nehme, dass ich plötzlich zehn Jahre jünger aussehe.
Natürlich liegt das nicht nur am Skinspan Gel allein – aber ich habe wirklich den Eindruck, dass es einen spürbaren Unterschied macht. Fast schon ein bisschen magisch.
Store owner replied:
Grazie per la tua dolce recensione! Siamo contenti che il SkinSpan Serum si stenda bene e nutra la tua pelle — è esattamente quello che ci auguriamo. Non vediamo l'ora di riavervi con noi al prossimo acquisto! Grazie per aver scelto AVEA!
Ottima crema.
Io ho la pelle del viso con pori "grandi", questa crema me li restringe e la pelle è più levigata.
Store owner replied:
Pori meno visibili e pelle più levigata – proprio l'effetto di Skinspan. Grazie! Il team AVEA
Sto usando il SIERO SKINSPAN da una ventina di giorni, lo adoro è una carezza per il viso... la mia pelle risulta morbida e idratata, potrei quasi far a meno della crema..
Ottimo prodotto, super consigliato.
Moira
Store owner replied:
Grazie mille per il tuo bellissimo feedback, Moira! Siamo felicissimi di sapere che SkinSpan Serum ti piaccia così tanto e che la tua pelle risulti più morbida e idratata. Ci fa davvero piacere leggere che per te sia come una “carezza” per il viso. Grazie anche per averlo consigliato e per aver condiviso la tua esperienza con la community AVEA!
Ein so angenehmes Gefühl auf der Haut, dass mein Mann regelmäßig davon partizipiert!
La pelle é visibilmente più compatta e luminosa. Fin dal primo utilizzo e con 1 sola applicazione al giorno, al mattino, prima della mia crema idratante con spf50.
Davvero un ottimo prodotto. Lo consiglio
Store owner replied:
Grazie per aver condiviso la tua esperienza. Ci fa davvero piacere sapere che stai notando risultati così rapidamente e che lo consigli!
ho iniziato da un mese e vedo già i primi risultati!!👌
Store owner replied:
Fantastico Enrico! Risultati già dopo un mese — non vediamo l'ora di vedere i prossimi progressi!
Ich liebe diese Produkte. Nehme sie seid einem Monat und bin sehr zufrieden. Ich sehe leichte Veränderungen an meiner Haut .Und bin sehr gespannt wohin mich die Reise noch führen wird.
Store owner replied:
Vielen Dank für dein schönes Feedback! Es freut uns sehr zu hören, dass du das SkinSpan System so gerne verwendest und bereits nach einem Monat erste Veränderungen an deiner Haut bemerkst.
Ho la sensazione di avere una pelle molto più nutrita e fresca; il siero non unge ma idrata in profondità.
Store owner replied:
Grazie mille per il tuo feedback! Siamo molto felici di sapere che SkinSpan Serum lascia la tua pelle più nutrita e fresca. È proprio ciò che vogliamo ottenere con la nostra formulazione: idratazione profonda con una texture leggera e non grassa.
Questo siero è miracoloso. Bellissima texture, si assorbe bene e lascia la pelle vellutata. Al risveglio la mia pelle appare più luminosa. Ottimo prodotto. Consigliatissimo
Store owner replied:
Siamo felicissimi che il SkinSpan Serum ti entusiasmi così tanto. Texture setosa, rapido assorbimento e quella pelle vellutata al tatto – è esattamente l’esperienza che vogliamo creare. E sapere che al risveglio la tua pelle appare più luminosa è il complimento più bello.
Ero inizialmente scettica ma ha cambiato la texture e luminosità della pelle del mio viso. Forse anche grazie all'utilizzo combinato ad Avea Booster, Avea VItalizer e Avea Collagen Activator! Prodotti davvero ottimi!
Store owner replied:
Siamo felici che SkinSpan Serum ti abbia sorpresa in modo così positivo e che tu abbia notato un miglioramento della texture e della luminosità della pelle ✨
La combinazione con Booster, Vitaliser e Collagen Activator può sicuramente sostenere la pelle anche dall’interno, in un approccio sinergico e pro ageing. È proprio questa visione olistica che rende i risultati più completi e armoniosi nel tempo.
Salve a tutti, completo la mia ruotin quotidiana con i miei integratori di marchio Avea per il benessere quotidiano, sono contenta e spero molto che possa essere d’aiuto anche agli altri per il benessere fisico. Advanced Skin Serum è un prodotto molto delicato sulla pelle, assorbe subito, non irrita la pelle lascia un velo delicato sul viso, la mia pelle è molto sensibile, dato che nel passato ho avuto la Rosacea e per me è molto importante saper di usare un prodotto molto valido e sicuro. È veramente ottimo prodotto grazie all’Avea !!!
Store owner replied:
Grazie mille per la tua recensione!
Siamo felici di sapere che SkinSpan Serum fa parte della tua routine quotidiana di benessere. È bellissimo vedere clienti che condividono le proprie esperienze per aiutare anche gli altri nella community. Grazie per il tuo contributo e per la fiducia in AVEA. ✨
Cremige Textur, lässt sich super auftragen und gibt ein samtiges Hautgefühl. Die Haut wirkt erfrischt und ist entspannt. Von mir gibt es 10 von 10 Punkten!
Store owner replied:
Siamo felici che il SkinSpan Serum sia diventato una vera coccola per la tua pelle fin dal primo utilizzo. Texture piacevole, assorbimento confortevole e risultati visibili nel tempo – è esattamente l’esperienza che vogliamo creare: supportare la pelle in modo mirato e duraturo.
Store owner replied:
Grazie mille per la tua recensione.
Siamo felici di sapere che il SkinSpan Serum ti piaccia e che apprezzi la sua texture leggera e non untuosa. Abbiamo formulato il siero per offrire performance e comfort insieme – assorbimento rapido, finish pulito e supporto mirato alla salute della pelle nel tempo.
Store owner replied:
Vielen Dank für dein Feedback! Unverzichtbar in der täglichen Routine — das ist das schönste Kompliment. Danke, dass du AVEA vertraust!
Store owner replied:
Grazie per la tua recensione! È bello sentire che lo scetticismo iniziale è stato superato dai risultati — una pelle più morbida e piena è esattamente ciò per cui il Skinspan System è formulato.
Das das Gel hat eine sehr schöne Konsistenz, zieht direkt ein und lässt meine Haut fest und strahlend erscheinen. Ich würde es jederzeit weiterempfehlen.
Store owner replied:
Vielen Dank für dein tolles Feedback! Schnell einziehend, feste und strahlende Haut — und eine klare Weiterempfehlung. Das freut uns sehr! Danke, dass du AVEA vertraust!
Sehr angenehmes Serum mit vielen sehr guten Inhaltsstoffen.
Store owner replied:
Vielen Dank für dein Feedback! Es freut uns sehr zu hören, dass dir SkinSpan Serum gefällt und du die hochwertigen Inhaltsstoffe schätzt.
Use this serum day and night.
It's spectacular!!!!
Store owner replied:
Thank you so much for your enthusiastic feedback!
We’re thrilled to hear that you love the SkinSpan Serum. Using it consistently morning and evening is a great way to support your skin’s regeneration and longevity from the outside in.
Store owner replied:
Thank you for your feedback! We're delighted to hear that you're experiencing positive results with the SkinSpan Serum. Formulated to target visible signs of skin ageing and support long-term skin health, it’s a key part of a science-backed pro-ageing routine. Thank you for trusting AVEA!
Hält meine Haut großartig versorgt und baut sie nach Chemo und Bestrahlung wieder auf.
Store owner replied:
Vielen Dank für dein Vertrauen und dein Feedback. Es freut uns sehr zu hören, dass dich das Serum in dieser Zeit so gut unterstützt und wünschen dir weiterhin nur das Beste!
Die Produkte sind sehr gut.
Dadurch habe ich meine Rosazea reduziert.
Petra
Store owner replied:
Vielen Dank für dein schönes Feedback, liebe Petra . Es freut uns sehr zu hören, dass du mit dem SkinSpan Serum so gute Erfahrungen gemacht hast und sogar eine Verbesserung deiner Rosazea bemerkst. Danke, dass du deine Erfahrung mit uns teilst.
Come detto, ho utilizzato la crema per 30 giorni ormai, la trovo buona ma lascia la pelle un po troppo appiccicosa come se no si assorbisse completamente
Store owner replied:
Grazie per aver condiviso la tua esperienza. Ci fa piacere sapere che nel complesso lo trovi un buon prodotto, anche se capiamo che la sensazione sulla pelle sia un aspetto importante. Se vuoi, scrivici pure a support@avea-life.com, saremo felici di aiutarti e capire insieme come migliorare la tua esperienza.
Sérum de qualité même s’il faut attendre quelques semaines pour avoir un effet visible.
Store owner replied:
Merci beaucoup pour ton retour ! 😊
Nous sommes ravis que tu considères le SkinSpan Serum comme un produit de qualité. Tu as tout à fait raison : les effets visibles peuvent parfois nécessiter quelques semaines d’utilisation régulière, le temps que la peau s’adapte et que les actifs agissent en profondeur.
Luminosità della pelle estremamente visibile, da una ottima idratazione anche se non si applica la crema dopo , prodotto top lo ricompro in associazione al collagene activator , insieme sono una bomba
Store owner replied:
Siamo felicissimi che tu veda una luminosità così evidente e che apprezzi l’idratazione del SkinSpan Serum, anche senza applicare la crema dopo. E adoriamo leggere che lo utilizzi in associazione al Collagen Activator – le nostre formule sono pensate proprio per lavorare in sinergia, dall’interno e dall’esterno.
siero che consiglio !!!!!
bello nella texture ed efficace sulla qualità del pelle!!! il viso cambia luminosità, diventando più compatto e disteso
Store owner replied:
Grazie mille per la tua recensione entusiasta.
Siamo felicissimi che consigli il Skinspan Serum e che tu ne apprezzi la texture e l’efficacia .Luminosità, compattezza e un aspetto più disteso del viso sono esattamente ciò che vogliamo supportare con questa formula – in modo visibile e nel tempo.
Texture fantastica, di assorbe subito e la pelle è subito elastica e idratata
Store owner replied:
Grazie mille per la tua recensione!
Siamo felici di sapere che apprezzi la consistenza di SkinSpan Serum, il rapido assorbimento e la sensazione di pelle levigata e compatta.
Produkt fühlt sich gut an!
Der Kundenservice ist sehr freundlich und hilfsbereit!
Store owner replied:
Grazie mille! Quando un prodotto diventa indispensabile nella routine, vuol dire che sta davvero funzionando.
trovo prodotto abbastanza valido . ha una buona idratazione. non so se un mesesia suficiente per capire il beneficio . credo che dopo un mese si dovrebberp già vedere minimi miglioramenti. non li ho notati in un modo evidente
Store owner replied:
Siamo felici che tu trovi il SkinSpan Serum valido e che apprezzi la sua buona idratazione. Per quanto riguarda i risultati: la risposta della pelle è molto individuale. Alcune persone notano miglioramenti visibili già dopo poche settimane, mentre per altre può essere necessario più tempo, soprattutto quando si tratta di compattezza e qualità della pelle nel lungo termine. La costanza è fondamentale. Se vuoi, scrivici a support@avea-life.com
– saremo felici di accompagnarti personalmente e capire insieme come ottimizzare la tua skincare routine
Mi piace molto questa crema idrata e si assorbe subito
Store owner replied:
Siamo felicissimi che il SkinSpan Serum ti piaccia così tanto! Una texture leggera, che idrata intensamente e si assorbe subito, è fondamentale per integrare la cura della pelle nella routine quotidiana – senza compromessi.
Store owner replied:
Grazie per il tuo bellissimo feedback! Siamo felici che lo SkinSpan Serum ti stia piacendo: la sua texture leggera e setosa è studiata per fondersi con la pelle, lasciandola nutrita, morbida e visibilmente più vitale. Sentire che dona una sensazione di benessere è la conferma del suo effetto mirato e profondo. Grazie per il tuo consiglio e per aver scelto AVEA!
Highly specialized approach often focusing on one major mechanism
Often relies on topically applied NAD+ precursors (NR/NMN) or general longevity complexes (Molecur 3™).
May focus on senolytics proven to reduce accumulated senescent cells.
Relies on traditional peptides (Copper Peptides) or standard growth factors to signal collagen production. Exosome technology is advanced and less common.
Focus often on Hyaluronic Acid (HA) or ceramides/barrier creams.
Varies, depends on the brand.
Typically primarily targets one concern at a time, e.g. NAD+ support.
Leading
Regular Serums
Focus on hydration, less focus on root causes.
May use Niacinamide (Vitamin B3) for broader benefits, but not typically centered on NAD+ optimization or NAMPT expression.
Often relies on exfoliating acids (Direct Acids) for surface clearance.
Utilizes basic peptides (e.g., Multi-Peptide + HA Serum) or antioxidants to support collagen.
Often backed by clinical studies focusing on the single active ingredient's effectiveness.
Primarily targets specific concerns like acne, pigmentation, or dryness, depending on the active ingredient.
Most anti-ageing serums target symptoms of ageing - dryness, fine lines, or loss of elasticity by stimulating or hydrating the skin. SkinSpan™ Advanced Skin Serum is built on cellular longevity science, designed to restore the fundamental biological processes that slow with age.
While many “longevity” formulas rely on a single mechanism (e.g., NAD⁺ boosters or peptides), SkinSpan™ Advanced Skin Serum integrates four proven pathways - cellular energy & renewal, collagen & elastin support, skin barrier defence & hydration. This systems-biology approach helps optimise how the skin generates energy, clears damage, and maintains structural integrity, rather than simply treating what’s visible at the surface.
When we say SkinSpan™ Advanced Skin Serum is based on longevity science, we mean that its formulation is built on the same biological principles used in cellular longevity research, i.e. the field that studies why cells age, how they lose function, and how we can maintain their performance over time.
In the context of skincare, it means that rather than temporarily addressing surface symptoms (e.g. hydrating the epidermis, exfoliating, temporarily tightening the skin, etc.) like most traditional skincare solutions , longevity skincare formulas are instead optimised to support long-term skin cellular health.
We designed SkinSpan™ Advanced Skin Serum to apply the core longevity principles we have in our supplements directly to the skin, using clinically studied ingredients that reactivate cellular energy metabolism (RejuveNAD™), promote cellular renewal (Cellaigie™), enhance fibroblast signalling (PhytoCellTec™ Exosomes) to further enhance the effects of your supplementation routine for a more complete inside-out approach to skin longevity.
NAD⁺ and autophagy are two fundamental pillars of cellular function that determine how effectively the skin repairs damage, produces collagen, and resists visible ageing.
NAD⁺ (nicotinamide adenine dinucleotide) is a molecule every cell needs to produce energy, repair DNA, and maintain healthy function. But NAD⁺ levels decline sharply with age, including in skin cells. When NAD⁺ drops:
Collagen production slows
Repair mechanisms become less efficient
Skin becomes thinner, duller, and more prone to damage
Environmental stress (UV, pollution) causes more harm
Supporting NAD⁺ metabolism helps skin cells regain the energy required for repair, renewal, and healthy collagen synthesis, all of which directly influence firmness, elasticity, and skin resilience. In SkinSpan™ serum, this is addressed through RejuveNAD™, which helps activate the skin’s natural NAD⁺ cycle.
Autophagy is the process through which cells “clean out” damaged proteins and waste so they can function optimally. As autophagy slows with age:
Cellular waste accumulates
Texture becomes rough and uneven
Radiance declines
Skin loses its ability to regenerate efficiently
Reactivating autophagy essentially tells skin cells to renew themselves, improving smoothness, clarity, and overall vitality. SkinSpan™ serum supports this with Cellaigie™, a peptide that encourages a renewal-focused state similar to the benefits seen in cellular detox pathways.
Together, NAD⁺ and autophagy determine how well skin cells can:
Repair daily damage
Stay energized
Produce collagen and elastin
Maintain an even, healthy texture
Resist environmental stressors
When both pathways decline (which naturally happens with age), visible aging accelerates. When both are supported, skin can behave more like it does in its younger years, renewing faster, repairing better, and maintaining healthier structure over time. This effect is further enhanced by supporting the skin with oral supplementation for a more complete inside-out approach.
Yes. SkinSpan™ Advanced Skin Serum was formulated without retinol, exfoliating acids, or fragrance - all common causes of irritation. Instead, it uses bioadaptive active ingredients such as Ectoin and Beta-Glucan, which have been clinically shown to reduce redness and strengthen barrier tolerance.
Ectoin and Betaine functions as an osmolyte, stabilising cell membranes under stress, while Beta-Glucan enhances skin recovery and hydration. Combined with Niacinamide, which improves lipid synthesis and barrier function, the serum not only avoids irritation but actively improves skin sensitivity and resilience.
The formula has been dermatologically tested.
Yes. SkinSpan™ Advanced Skin Serum is compatible with most active ingredients, including vitamin C, niacinamide, and exfoliating acids. It can also be layered with retinol-based products.
If using strong retinoids or chemical exfoliants, apply SkinSpan™ Advanced Skin Serum before those active ingredients to reduce irritation and reinforce the barrier. Its barrier-repairing ingredients (Niacinamide, Beta-Glucan, Ectoin®) help maintain balance in routines with potent active ingredients.
Always follow with a moisturizer and daily SPF to preserve the skin’s integrity.
Apply one to two pumps to clean, dump skin twice daily - morning and evening.
Gently press into the face, neck, and décolletage until absorbed. Use before moisturizer or sunscreen during the day, and before your night cream in the evening.
For deeper results, pair with AVEA’s oral formulations (Collagen Activator and SkinSpan) for a more complete inside-out approach to skin health.
A pea-sized amount (one pump) is sufficient for the entire face. The serum is highly concentrated - our formulation comprises clinically studied active ingredients - so using more does not enhance results. Consistency, not quantity, drives the best results.
SkinSpan™ Advanced Skin Serum is developed and manufactured in Switzerland under GMP-certified conditions.
The formulation was created in collaboration with leading longevity scientists to ensure precision, stability, and bioavailability of each active compound. Each ingredient is sourced from traceable suppliers with clinical validation and tested for purity and safety.
Yes, they are designed to work synergistically.
The serum targets the skin’s surface and cellular interface - restoring NAD⁺, autophagy and cell renewal.
The Collagen Activatorsupplies the molecular building blocks and cofactors needed for new collagen synthesis, while the SkinSpan™ Supplement supports hydration, ceramide production, and cellular renewal.
Together, they reinforce each other’s pathways, creating a closed-loop system that supports skin structure, moisture, and biological longevity across all layers.
SkinSpan™ Advanced Skin Serum is substantiated at two levels: the individual active ingredients are each backed by clinical research, and the finished formula itself has been tested in an 8-week dermatologist-supervised instrumental study conducted in 2026.
In an instrumental use-test of 20 healthy adult volunteers (35–65 years, QACS Laboratory, Athens, 2026), twice-daily application of SkinSpan™ Advanced Skin Serum produced the following statistically significant results:
The visible appearance of wrinklesreduced by 31% within 4 weeks, with continued improvement to −21% in overall wrinkle severity at 8 weeks — measured by VISIA complexion analysis imaging
Skin elasticity improved by 30% after 4 weeks, sustained at +26% at week 8 — measured by Delfin ElastiMeter
Skin moisture levels increased by 21% and transepidermal water loss reduced by 19.4% within 30 minutes of first application — measured by Corneometer® and Tewameter®
All primary efficacy endpoints reached statistical significance (p < 0.05)
The formula was well tolerated by all 20 volunteers, with zero adverse events recorded
In the accompanying self-assessment questionnaire, 95% of users found the texture pleasant, 90% felt their skin more elastic and hydrated, and 85% said they would recommend SkinSpan™ to others.
The finished formula is dermatologically tested in Switzerland to verify tolerance and compatibility.
SkinSpan™ Advanced Skin Serum enhances cellular performance while it’s used, much like exercise strengthens muscle. Once discontinued, the biological benefits (improved NAD⁺ activity, barrier integrity, collagen signalling) gradually decline as natural ageing processes resume.
However, stopping use will not cause a rebound effect or deterioration; the skin will simply return to its baseline rate of renewal. For sustained improvement, consistent application maintains the biological optimisation SkinSpan™ Advanced Face Serum helps achieve.
At AVEA, every formulation begins with a deep understanding of the biological processes that drive ageing – and how we can influence them. Our work is grounded in the latest findings from the fields of cellular health, metabolic and longevity science.
Led by our Co-Founder and Chief Science Officer, Sophie Chabloz, our in-house science team partners with world-class longevity researchers and biotech experts from leading academic institutions. Together, we translate complex, peer-reviewed research into targeted, effective supplement formulas designed to support cellular function, resilience, and long-term vitality.
Each supplement we create is based on clinically studied ingredients, optimised for bioavailability, and rigorously tested – so that what works in the lab also works in your daily life.
Your supplements will be dispatched from our NL warehouse within 24 hours.
We ship internationally and offer a variety of shipping options:
Standard shipping is free for orders over £50 and is sent via local postal services.
For faster delivery, we also offer express options via commercial carriers, depending on your destination.
All available shipping methods – along with estimated delivery times and final costs – will be displayed during checkout.
If your country isn’t listed at checkout, feel free to contact our customer service team at support@avea-life.com, and we’ll be happy to explore possible solutions.
The full benefits of skincare cosmetics take time to develop. Many customers notice initial improvements within the first month, while the full effect typically unfolds after 2–3 months. Since everyone is unique, results may vary. That’s why we recommend following your new routine for at least 3 months.
If you’re not satisfied after this period, you can make use of our 90-day money-back guarantee.
Frequently asked questions
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