NMN

NMN

What is NMN?

NMN, short for nicotinamide mononucleotide, is a naturally occurring vitamin B3 derivative. NMN is a precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme present in all human cells. NAD+ is essential for life and is linked closely to metabolism and ageing. 

Where can it be found in nature?

NMN is naturally present in our food, including milk, meat, avocado, broccoli, cabbage, cucumber, and edamame. However, it would be nearly impossible to get an efficient dose from food alone. You’d need to consume almost 100kg of broccoli or 416kg of beef just to get 250mg of NMN, the dose provided in our daily supplement.

What are its primary functions?

NMN becomes NAD+ in our bodies, and NAD+ is involved in hundreds of metabolic processes throughout the body. Its most crucial roles include helping turn nutrients into energy and working as a fuel for the enzymes involved in DNA protection and repair. Accumulating evidence suggests that NAD+ systemically declines with age and contributes to the development of age-related diseases. A 50-year-old, for example, has roughly half the levels of NAD+ as a 20-year-old. Of course, you can live with low levels of NAD+, but it will accelerate the ageing process and reduce your healthspan. Fortunately, increasing NAD+ levels has many health benefits for various organs, including the brain, cardiovascular system, and skin elasticity.

What are the benefits of taking NMN?

NMN targets the natural decline of NAD+ in our bodies as we age. By restoring NAD+ levels, NMN supplements help you regain, sustain, and maintain vibrant health and energy through the years. A number of studies have shown the beneficial effects of NMN on energy levels, memory, blood vessel health, metabolism, stem cell health, epigenome maintenance, and DNA damage repair. In a clinical study in 2014, for instance, a team of researchers led by Dr. David Sinclair, professor of genetics at Harvard Medical School and expert on biological ageing, demonstrated that NMN can extend lifespan, and a later study showed that NMN increases NAD+ levels and reverses DNA damage.

Why do we use NMN in our supplements?

NMN is one of the most promising supplements for slowing ageing. Since NMN gets converted into NAD+ in our cells, it can effectively replenish NAD+, helping you regain your health and energy to youthful levels. NMN is proven to be safe, stable, and effective. Continuous clinical trials demonstrate and unveil more of its benefits.

Sources

1. Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell metabolism, 27(3), 529–547. https://doi.org/10.1016/j.cmet.2018.02.011 
2. North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michan, S., Dai, J., Baker, D. J., Cen, Y., Wu, L. E., Sauve, A. A., van Deursen, J. M., Rosenzweig, A., & Sinclair, D. A. (2014). SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO journal, 33(13), 1438–1453. https://doi.org/10.15252/embj.201386907 
3. Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V., Aravind, L., Steegborn, C., & Sinclair, D. A. (2017). A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.), 355(6331), 1312–1317. https://doi.org/10.1126/science.aad8242 
4. Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., Csiszar, A., & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. GeroScience, 42(2), 527–546. https://doi.org/10.1007/s11357-020-00165-5
5. Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S. I., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science (New York, N.Y.), 372(6547), 1224–1229. https://doi.org/10.1126/science.abe9985