NAD+ SCIENCE

NAD+ plays an essential role in cellular processes that protect us from ageing and disease. But as we age, our NAD+ levels decrease. Through breakthrough scientific innovation, it is now possible to replenish and maintain youthful NAD+ levels.

WHAT IS NAD+?

NAD+ is found in every cell of your body.

NAD+, or nicotinamide adenine dinucleotide, is a coenzyme that naturally occurs in the cells of all living organisms, from fruit flies to humans. Mitochondria‒the energy generators of cells‒require NAD+ to function well. NAD+ also helps convert nutrients from the foods you eat into energy and plays a crucial role in maintaining DNA health and regulating cellular function. These processes work together to lessen the effects of ageing and disease on your body.

HOW DOES NAD+ SUPPORT LONGEVITY?

Increasing NAD+ shows promise for extending healthspan and lifespan.

As you age, your NAD+ levels decrease dramatically, increasing the likelihood of faster ageing, heart disease, metabolic disorders, such as diabetes, neurodegenerative conditions, such as Alzheimer’s disease, and other age-related diseases.

Now, the good news: Replenishing NAD+ levels with precursors, such as NMN (nicotinamide mononucleotide), has demonstrated long-term health benefits. The effect shows promise for reversing age-related diseases, and increasing lifespan and healthspan—the number of healthy, disease-free years of your life.

THE HISTORY OF NAD+

NAD+ has been one of the most researched molecules in biology and medicine ever since its discovery in 1906, and in recent years, scientists have explored increasing NAD+ levels with supplements. Here’s the abbreviated history of NAD+.

THE ROLE OF NAD+

NAD+ is essential for all your cellular processes.

NAD+ works as a shuttle bus within your cells, transferring electrons from one molecule to another to perform various reactions and processes. For example, NAD+ is particularly important for energy generation.

NAD+ also serves as fuel to activate sirtuins, a family of proteins connected to healthy ageing and longevity. Sirtuins use NAD+ to regulate metabolism, maintain genomic stability, and repair damaged DNA.

REPLENISH AND MAINTAIN NAD+ LEVELS

It is now possible to replenish and maintain youthful NAD+ levels.

BUNDLE

Prevent and repair the hallmarks of ageing with this powerful combo

Get the best of both NAD+ supporting supplements. The Booster and the NMN are a powerful duo of high-quality, bioavailable ingredients that target diverse mechanisms of ageing at the cellular level, leaving you feeling more energized, youthful, and vibrant. Our NMN capsule contains 250 mg of Uthever® NMN, and our Booster combines 400 mg of active ingredients, including resveratrol, betaine, and more.

References
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  3. Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V., Aravind, L., Steegborn, C., & Sinclair, D. A. (2017). A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.), 355(6331), 1312–1317. https://doi.org/10.1126/science.aad8242
  4. Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., Csiszar, A., & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. GeroScience, 42(2), 527–546. https://doi.org/10.1007/s11357-020-00165-5
  5. Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S. I., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science (New York, N.Y.), 372(6547), 1224–1229. https://doi.org/10.1126/science.abe9985
  6. Poljsak, B., Kovač, V., & Milisav, I. (2020). Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?. Oxidative medicine and cellular longevity, 2020, 8819627. https://doi.org/10.1155/2020/8819627