Sereniser Science

The Sereniser is formulated with clinically studied extracts like Safr’Inside™, Holixer™, and Serezin™, along with L-theanine, Magnesium Bisglycinate, and Vitamin B6. It’s designed to support the body’s natural sleep architecture by balancing cortisol, promoting GABA and serotonin activity, and restoring deep, uninterrupted rest – without sedation or dependency.

The science of restorative sleep

How the Sereniser supports your body’s natural sleep rhythm

SCIENCE-BACKED BOTANICALS & NUTRIENTS

Clinically studied ingredients that support better sleep, naturally

Safr’Inside™

A standardised, patented, highly bioavailable saffron extract shown to improve sleep quality, reduce time to fall asleep, and ease anxious thoughts — all by supporting serotonin-melatonin conversion and cortisol balance.

Holixer™

A clinically studied Holy Basil extract that helps regulate cortisol levels, reduce stress, and support parasympathetic nervous system activity — promoting calmer nights and deeper rest.

Serezin™

A botanical duo of Ginger and Boswellia extracts designed to relieve nighttime discomfort and support restorative sleep. Clinically shown to improve sleep quality and make waking up easier.

L-Theanine

An amino acid found in green tea, known for promoting a calm state without sedation. L-theanine supports alpha brain waves — helping reduce mental overstimulation and ease into sleep, even after a hectic day. It’s also known to offset the jittery effects of caffeine, making it ideal for restoring calm in the evening.


Magnesium Bisglycinate

A highly bioavailable and gentle form of magnesium that helps relax muscles, calm the nervous system, and support deep sleep. Bisglycinate is bound to glycine — an amino acid that enhances absorption and has its own calming effect, making it especially effective for sleep without digestive discomfort.

Vitamin B6

An essential cofactor for the production of GABA and serotonin — two key neurotransmitters involved in mood and sleep regulation. Vitamin B6 helps support a balanced circadian rhythm and contributes to better stress resilience and emotional stability.

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1. Fall asleep faster

Calm your nervous system and ease into rest

Falling asleep isn’t just about feeling tired — it’s about creating the right internal conditions: calming brain activity, relaxing the body, and triggering your natural melatonin rhythm. The Sereniser supports this process by combining L-Theanine, which promotes alpha brain waves and reduces mental overstimulation, with magnesium bisglycinate to support GABA signalling and ease physical tension. Together with Safr’Inside™, a standardised saffron extract shown to support serotonin regulation, these compounds help your brain shift smoothly into a sleep-ready state — setting the stage for deep, natural rest.

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2. Stay Asleep Longer

Support deep, stable, uninterrupted sleep

Many people don’t struggle to fall asleep — they struggle to stay asleep. Mid-night wakeups are often caused by cortisol spikes, restlessness, or dysregulated sleep rhythms. The Sereniser targets these pathways with Holixer™, a plant-based extract of holy basil that has been clinically shown to reduce perceived stress and help stabilise nighttime cortisol levels. Safr’Inside™ supports ongoing serotonin–melatonin balance, while Serezin™, a botanical complex of ginger and boswellia, helps reduce nighttime tension and physical discomfort — two subtle but powerful disruptors of continuous sleep.

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3. Wake Up Refreshed

Feel mentally clear and physically recharged in the morning

The goal isn’t just sleep — it’s sleep that restores. The Sereniser supports your body’s ability to complete full sleep cycles, including deep and REM phases, so you wake up feeling like yourself again. Its non-sedative formula avoids grogginess or dependency, while Serezin™ has been shown to improve ease of waking and morning clarity in clinical studies. Magnesium bisglycinate and vitamin B6 help maintain neurotransmitter balance overnight — supporting emotional calm and next-day resilience.

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The smarter way to sleep

Non-sedative. Non-habit forming. Truly restorative.

Most sleep supplements override your system. The Sereniser supports it. By supporting key pathways like GABA, serotonin, and cortisol — without melatonin or sedation — it helps you fall asleep naturally, stay asleep longer, and wake up refreshed. No grogginess. No dependency. Just better sleep, night after night.

SCIENTIFIC EVIDENCE

The science behind the benefits

Benefits References
Reduces perceived stress and cortisol levels

Lopresti et al., 2022

Saxena et al., 2011

Hidese et al., 2019

Wang et al., 2022

Pouchieu et al., 2023

Improves sleep quality and duration

Lemoine et al, 2019

Breus et al., 2024

Lian et al., 2022

Kim et al., 2019


Supports melatonin rhythm via serotonin balance

Jadidi et al, 2022

Field et al., 2022

Enhances sleep continuity and morning clarity

Abbasi et al., 2012

Pachikian et al., 2021

Ingredient safety profile
Ingredients References
Safr’Inside™ (Saffron Extract)

Jackson P.A., et al., 2021

Noorbala A.A., et al., 2005

Holixer™ (Holy Basil Extract)

Lopresti A.L., et al., 2022

Serezin™ (Ginger + Boswellia Extracts)

PLT Health

L-Theanine (from Green Tea Extract)

Lyon M.R., et al., 2011

Magnesium Bisglycinate

European Food Safety Authority

Vitamin B6 (as Pyridoxal-5-Phosphate)

European Food Safety Authority