STABILISER SCIENCE

Our Stabiliser is a revolutionary natural blood sugar stabilising formula that blocks the absorption of carbs by up to 40% while you eat. Here’s the real kicker: it helps you avoid blood sugar spikes and crashes while still allowing you to enjoy the foods you love.

Longevity Science NAD+ NMN Booster StabiliserDNA & Bioage Test Collagen Activator Mobiliser Essentials
WHAT IS THE STABILISER AND WHAT DOES IT DO?

Keep your blood sugar in check. Keep the foods you love.

Our Stabiliser is formulated with a unique combination of 3 natural ingredients that will help you optimise your health. This revolutionary formula allows you to regulate your blood-sugar levels by slowing and blocking the absorption of carbs during a meal, minimising glucose peaks and the associated “sugar crashes'' that make you feel tired, while still allowing you to enjoy the foods you love. The Stabiliser also increases insulin sensitivity, concurrently helping you achieve and keep a healthy weight as well as avoid multiple metabolic diseases that usually become more prevalent as you age.

BENEFITS OF STABILISING BLOOD SUGAR

​​Stabilising your blood sugar levels has many benefits which can truly help you feel better now and prevent serious health problems later.

MEET OUR 3 POWERFUL INGREDIENTS

The ingredients in the Stabiliser have been carefully selected for their proven health benefits. Our experts crafted this unique combination in the right dosages to safely and effectively balance your blood sugar levels.

White Mulberry Leaf (Reducose®)

A natural leaf extract that inhibits the absorption of sugars and carbs by up to 40% while you eat, turning fast sugar and carbs into slow ones.

The Science Behind White Mulberry Leaf (Reducose®)

Reducose® (White Mulberry Leaf Extract)

What it is: A patent-protected extract from White Mulberry leaves, which are widely recognised for their health benefits. Reducose has been validated in multiple clinical trials for being both safe and effective.

What it does:Blocks the absorption of sugar and carbs while you eat, so you don't experience sugar crashes, feel full for longer and thus, help you manage your weight.

What is Reducose®?

Reducose® is a patented White Mulberry leaf extract rich in alkaloids and flavonoids. While they have recently gained popularity as ‘’superfoods’’ in the west, Mulberry leaves have been used in traditional medicine for ages in Asian countries for their blood sugar balancing benefits. In recent scientific studies, Reducose® has been shown to have multiple health benefits, including lowering blood sugar levels and possibly preventing cardiovascular diseases, obesity, and diabetes.

Where can it be found in nature?

The Mulberry (Morus) tree is native to China. It belongs to the Moraceae plant family and includes several species. Reducose® is extracted from White Mulberry leaves that are usually cultivated in Thailand, according to EU organic guidelines to achieve peak quality and sustainability.

What are its primary functions and benefits?

Clinical trials have shown significant decreases in post-meal blood glucose levels upon administration of Reducose®. It acts immediately at the very early stages of digestion by inhibiting the breakdown and absorption of carbs in your intestine, before they even reach your bloodstream. Your post-meal blood-sugar levels are thus successfully balanced without resulting in any spikes. As such, Reducose® also acts as a powerful weight management tool by allowing you to feel full for longer, and further propelling your body to increase its fats and lipids utilisation to provide energy.

Furthermore, a low insulin level enhances your brain's ability to exhibit improved memory, attention, and cognitive performance. Now, the cherry on top? There have been no reported side-effects with Reducose® as it remains unaltered, and is easily excreted from the body. The undigested carbs end up as prebiotics in the gut microbiome.

When it comes to delaying the onset of age-related diseases, Reducose® has additional metabolic health benefits. It mimics calorie restriction (while still allowing you to indulge in healthy diets), which has repeatedly been shown to increase lifespan by activating the sirtuin pathway, reducing oxidative stress and inflammation, as well as minimising the risks of cardiovascular and kidney diseases.

Why do we use Reducose® in our supplements?

We chose Reducose® as one of the key players in our Stabiliser, primarily for its ability to effectively reduce post-meal glucose spikes - a benchmark well-known for a healthy heart, healthy weight, and healthy ageing. This effect can also be attained through challenging methods like calorie restriction or intermittent fasting, Reducose® just makes it easier.

Additionally, Reducose® supports cellular and DNA repair by inducing its anti-inflammatory and antioxidant effects. It also frees up NAD+, a crucial molecule needed to activate the infamous ‘’longevity-genes’’ called sirtuins. Researchers have firmly established sirtuins' critical role as a longevity regulator, as they maintain healthy circadian rhythms and metabolisms.

Another factor triggering our choice for Reducose® is that its immediate blood-glucose effect can be easily monitored in real-time via technological innovations like Continuous Glucose Monitor (CGM) which enables you to understand your metabolism.

Sources

  1. Thondre et al, 2021. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomised, double-blind, placebo-controlled study. Nutrition & Metabolism; 18:41.
  2. Wang et al, 2018. Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates. Medicine (2018) 97:34.
  3. Li et al., 2018. Safety evaluation of mulberry leaf extract: acute, subacute toxicity and genotoxicity studies. Regulatory Toxicology and Pharmacology; 95: 220-226.
  4. Lown et al, 2017. Mulberry extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: results of a randomized double-blind placebo controlled study. PLOS ONE.
  5. Liu et al, 2016. Prevention effects and possible molecular mechanism of mulberry leaf extract and its formulation on rats with insulin sensitivity. PLOS ONE.
  6. Lown et al, 2016. Mulberry extract Reducose® total blood glucose in normoglycaemic adults. Diabetes UK Annual Conference
  7. Marx et al, 2016. 28-day repeat dose toxicological study of an aqueous extract on Morus alba. L. Int. J. Tox.
  8. Lown et al, 2015. Mulberry extract to modulate Blood glucose Responses in normoglycaemic adults (MULBERRY) study protocol for a randomized controlled study. TRIALS.
  9. Asai et al. 2011. Effect of mulberry leaf extract enriched with DNJ on post prandial glycaemic control in subjects with impaired glucose metabolism. J. Diab. Inv.
  10. Kim et al., 2015. Mulberry extract improves postprandial glucose response in prediabetic subjects. J. Med. Food.
  11. Kimura et al, 2007. Food grade mulberry powder suppresses elevation of post-prandial blood glucose in humans. J. Agric. Food Chem.
  12. Kojima et al, 2010. Effects of Mulberry leaf extract on blood lipid profiles. J. Clin. Biochem. Nutr.
  13. Chung et al., 2-13. Acute intake of mulberry leaf extract affects postprandial glucose response after maltose loading. J. Func. Foods.
  14. Mudra et al., 2007. Influence of mulberry leaf extract on blood glucose and breath hydrogen response to ingestion of 75g sucrose by type-2 diabetic and control subjects. Diabetes Care.
  15. Nakamura et al., 2009. Suppressive response of confections containing the extractive from leaves of Morus alba on postprandial blood glucose and insulin. Nutr. & Metab.
  16. Jozefczuk et al., 2017. Mulberry leaf extract decreases digestion and absorption of starch in healthy subjects. Adv. Med. Sci.
  17. Phimarn et al., 2017. Meta-analysis of efficacy of Morus alba to improve blood glucose and lipid profile. Eu. J. Nutr.

Chromium Picolinate

One of the most bioavailable forms of the essential mineral Chromium, shown to improve blood sugar control by boosting carbs, proteins, and fats metabolism. May help in reducing hunger and cravings.

The Science Behind Chromium Picolinate

Chromium Picolinate

What it is: One of the most well-absorbed forms of chromium, an essential and well-studied mineral which must be obtained from food since it cannot be synthesised by your body.

What it does:Improves your body’s response to insulin and lowers your blood-glucose levels by enhancing sugar metabolism. Additionally, it may also help in decreasing hunger and cravings, thereby allowing for healthier weight management.

What is Chromium Picolinate?

Chromium is an essential mineral which exists in several forms. Chromium Picolinate is one of the most bioavailable forms of Chromium that can be found in minute amounts in foods. Multiple scientific studies are now revealing the potential health benefits of supplementing with Chromium Picolinate, when it comes to reducing the risks of obesity, diabetes, and cardiovascular diseases.

Where can it be found in nature?

It is usually found in trace amounts in meat, whole grains, some fruits and vegetables, different spices, brewer's yeast, beer, and wine. However, the Chromium amounts present in these foods vary largely, depending on the agricultural and manufacturing processes involved. Thus, to exploit the potential health benefits that Chromium has in your body, it is a good idea to consider supplements, including our Stabiliser.

What are its primary functions and benefits?

Research in diabetic laboratory animals has shown the clear ability of Chromium Picolinate to regulate healthy blood-sugar levels by increasing the activity of insulin, and lowering the amounts of glucose that are left to circulate in the bloodstream. In fact, Chromium and insulin work cooperatively to prevent damages that are associated with a high blood-glucose level. In particular, Chromium Picolinate can help in preventing diabetes, obesity, heart diseases, strokes, oxidative stress, chronic inflammation and even neuropathy.

Chromium Picolinate supplementation has also shown enhanced performance amongst athletes and bodybuilders, in addition to promoting loss of fats instead of muscles. Furthermore, some forms of depression, typically those characterised by frequent mood changes and disturbed eating and sleeping patterns, may also be helped by the supplementation of Chromium. Recent evidence from the neuroscience field also uncovers the potential benefits of Chromium Picolinate in improving cognitive functioning and memory in adults.

Why do we use Chromium Picolinate in our supplements?

We chose Chromium Picolinate mainly for its assistance in reducing insulin resistance and glucose tolerance - the basis of multiple metabolic diseases, including obesity. Basically, Chromium is an essential mineral that has a crucial role in insulin signalling. As dietary Chromium is typically poorly absorbed, and as your Chromium levels decline with age, supplements like our Stabiliser become fundamental.

Besides, the high absorption rate of Chromium Picolinate may also play a role in maintaining a healthy cholesterol profile by reducing the excess fats in your bloodstream. Plus, it has been shown to simultaneously promote the relaxation of blood vessels and improve blood flow.

We ensured a verified and minimal dosage of Chromium Picolinate in our Stabiliser to prevent plausible interactions with other diabetes medication. Yet, we still recommend you talk to your healthcare provider if you also take diabetes medication.

Sources

  1. Brownley, K. A., Von Holle, A., Hamer, R. M., La Via, M., & Bulik, C. M. (2013). A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and Chromium (BEACh) study. Journal of psychosomatic research, 75(1), 36–42.
  2. John B. Vincent, The Biochemistry of Chromium, The Journal of Nutrition, Volume 130, Issue 4, April 2000, Pages 715–718
  3. Vincent JB. The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent. Sports Med. 2003;33(3):213-30.
  4. Suksomboon N, Poolsup N, Yuwanakorn A. Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. J Clin Pharm Ther. 2014 Jun;39(3):292-306.
  5. Pei D, Hsieh CH, Hung YJ, Li JC, Lee CH, Kuo SW. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism. 2006 Jul;55(7):923-7.

Berberine

A polyphenol found in various plants, shown to lower fasting blood sugar levels, support weight loss, and improve heart health by lowering cholesterol.

The Science Behind Berberine

Berberine

What it is: A yellow-colored polyphenol found in multiple plant species, which is supported by scientific research for its properties in lowering blood-sugar levels, improving insulin resistance, and also reducing the risks of cognitive impairment.

What it does:Acts on fasting glucose and improves insulin sensitivity by activating enzymes that regulate your blood-glucose level. It also reduces oxidative stress and inflammation in your cells, further inducing metabolic homeostasis.

What is Berberine?

Berberine is a polyphenol that can be found in the roots, rhizomes, and stem barks of many plant species. With a history of being used for over 2500 years in Ayurvedic and Chinese medicine, the natural supplement is a yellow compound also supported by scientific research for its multiple pharmacological properties, including lowering blood-sugar levels, improving insulin resistance, and reducing risks of cognitive impairment. Pubmed shows that research published on Berberine is on a steady rise, with over 630 papers published in 2020 alone.

Where can it be found in nature?

Many plant species contain Berberine including goldthread, Oregon grape, and barberry. Plants of this genus are often used against inflammation, infectious diseases, diabetes, constipation, and other pathologies. While multiple studies revealed the beneficial effects of supplemental berberine and barberry extracts, the relative amount of fresh or dried barberries to be consumed remains unclear. Another reason to consider our Stabiliser supplement!

What are its primary functions and benefits?

Acting at molecular level, Berberine’s health benefits have been intensively studied in clinical trials for lowering blood sugar, lipids, high cholesterol and hypertension. Essentially, it activates an enzyme needed to decrease insulin resistance.

Insulin resistance occurs when your body needs more and more insulin to function properly - the leading cause of Type II diabetes, inflammation and cardiovascular diseases globally. Decreasing insulin resistance not only reduces the risk of such chronic diseases, but it also optimises metabolism and weight management by stimulating better glucose uptake, and the effective usage of fats as fuel.

Furthermore, no significant difference has been observed between the effects of Berberine and other Type II diabetes prescription drugs. In fact, both studies show similar declines in HbA1c levels (a marker of glucose management in diabetics), with no remarkable side effects from Berberine. As a matter of fact, a linear correlation between circulating HbA1c levels and cognitive decline (regardless of diabetic status) has also been observed. Thus, supplementing with Berberine will not only improve your blood-sugar levels, but also enhance your immune system and promote healthy brain cell production.

Why do we use Berberine in our supplements?

We chose Berberine because of its potential to activate the crucial enzyme AMPK, which essentially generates the same benefits as exercising, dieting or weight management - the healthy lifestyle modifications you know you should implement when it comes to improving your health, but which can sometimes still be challenging. On the plus side, Berberine has the same effects as increasing exercise and restricting your calorie intake altogether.

Additionally, when used in combination with other agents, Berberine has consistently exhibited multiple pharmacological and therapeutic actions, such as antioxidant and immunomodulatory effects, protective action on the cardiovascular system, liver and kidney, endothelial relaxation, as well as regulator of glucose metabolism. This is yet another major reason why we chose Berberine to partner with the other two ingredients in our Stabiliser supplement. For instance, Berberine acts by lowering your fasting glucose levels, while Reducose on the other hand, will act on your post-meal glucose levels.

As higher doses of Berberine can interfere with other medications, our Stabiliser supplement contains the ideal concentration of Berberine that will help extend your lifespan and metabolism without causing any discomfort.

Sources

  1. Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758350/
  2. Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) | Nature Communications https://www.nature.com/articles/s41467-020-18414-8
  3. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression https://pubmed.ncbi.nlm.nih.gov/31773901/
  4. Berberine and probiotics combo successful in reducing blood sugar level in diabetic patients – China 12-week RCT https://www.nutraingredients-asia.com/Article/2020/11/23/Berberine-and-probiotics-combo-successful-in-reducing-blood-sugar-level-in-diabetic-patients-China-12-week-RCT
  5. Comparison Among Garlic, Berberine, Resveratrol, Hibiscus sabdariffa, Genus Zizyphus, Hesperidin, Red Beetroot, Catha edulis, Po https://journals.sagepub.com/doi/pdf/10.1177/1934578X20921623
  6. Berberine Prolongs Life Span and Stimulates Locomotor Activity of Drosophila melanogaster - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498586/
  7. Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478874/
  8. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine https://pubmed.ncbi.nlm.nih.gov/18397984/
  9. Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes https://pubmed.ncbi.nlm.nih.gov/27887947/
  10. Clinical Applications for Berberine | Natural Medicine Journal https://www.naturalmedicinejournal.com/journal/clinical-applications-berberine
MECHANISM OF ACTION

Strike the sugar spike.

Usually, your carbohydrate digestion works like this:

You enjoy a nice plate of pasta for lunch, which causes your blood glucose to spike and then crash about 2 hours later. You feel tired and focusing becomes hard. This is what we call “the sugar crash”. It doesn’t have to be this way: when you take our Stabiliser before eating the same plate of pasta, the glucose spike is flattened and the crash avoided, allowing you to keep your energy and focus.

Thanks to Reducose®, the Stabiliser tackles blood sugar spikes before they happen. By blocking and slowing carbohydrate absorption in the gut, before reaching the bloodstream, your post-meal blood glucose levels are naturally balanced before they can even spike.

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MECHANISM OF ACTION

It’s not sorcery, it’s science!

Reducose® is a leaf extract from the White Mulberry (M. alba) plant which has been used in traditional medicines in Asian countries since the dawn of time. This natural food ingredient is getting widely recognised for its multiple health benefits amongst the scientific community.

At a cellular level, Reducose® exerts its beneficial effects by turning fast sugars and carbs into slow ones. Basically, it binds to the enzymes which are needed to convert carbs into glucose. Result? Your post-meal blood-sugar and insulin levels are reduced by up to 40%! With a lowered-insulin secretion, your cells are forced to effectively use fats and lipids as fuel, thereby also allowing for healthier weight management.

Reducose® also improves cognitive function since your brain actually thrives on lower insulin levels. The cherry on top with our Stabiliser supplement is that there have been no reported side-effects with Reducose as it remains unaltered, and is easily excreted from your body. The undigested carbs end up as prebiotics in your gut microbiome allowing healthy bacteria to grow. It’s a win-win situation!

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THE STABILISER

Enjoy the difference.

Our uniqueness also stems from the additional benefits brought in by Berberine and Chromium Picolinate, included in our Stabiliser alongside Reducose®. As a whole, the 3 chosen ingredients work in synergy to safely boost your body into a fat-burning mode, further helping you maintain a healthy blood-sugar level.

For instance, while Berberine will act by lowering your fasting glucose levels, Reducose® will act on your post-meal glucose levels. To top it off, Chromium will assist by considerably increasing your insulin activity. Our stabiliser is the ultimate key to a healthy heart and a healthy weight!

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LAST BUT NOT LEAST

Low blood sugar is good for your skin.

Stabilising your blood sugar levels reduces glycation resulting in less skin damage and ageing.

Sustained high levels of sugars in the blood ultimately cause proteins to stick together in a process called glycation. This forms advanced glycation end products (appropriately abbreviated to AGEs), which damage the function of the proteins. The proteins in skin most prone to glycation when blood sugar is in excess are the same ones that keep a young complexion plump and supple-collagen and elastin. When those proteins hook up with sugars, they become discoloured, weak, and less elastic, which leads to premature wrinkling, sagginess and age spots.

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References
  1. Thondre et al, 2021. Mulberry leaf extract improves glycaemic response and insulinemic response to sucrose in healthy subjects: results of a randomised, double-blind, placebo-controlled study. Nutrition & Metabolism; 18:41.
  2. Wang et al, 2018. Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates. Medicine (2018) 97:34.
  3. Li et al., 2018. Safety evaluation of mulberry leaf extract: acute, subacute toxicity and genotoxicity studies. Regulatory Toxicology and Pharmacology; 95: 220-226.
  4. Lown et al, 2017. Mulberry extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: results of a randomised double-blind placebo controlled study. PLOS ONE.
  5. Liu et al, 2016. Prevention effects and possible molecular mechanism of mulberry leaf extract and its formulation on rats with insulin sensitivity. PLOS ONE.
  6. Lown et al, 2016. Mulberry extracts Reducose® total blood glucose in normoglycaemic adults. Diabetes UK Annual Conference
  7. 1. Birdsall T, Kelly G. Berberine: therapeutic potential of an alkaloid found in several medicinal plants. Alt Med Rev. 1997;2(2):94-103.
  8. 5. Lee YS, Kim WS, Kim KH, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes. 2006;55(8):2256-2264.
  9. Xu Z, Feng W, Shen Q, Yu N, Yu K, Wang S, Chen Z, Shioda S, Guo Y. Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation. Aging Dis. 2017 Dec 1;8(6):760-777. doi: 10.14336/AD.2016.0620. PMID: 29344415; PMCID: PMC5758350.
  10. Brownley, K. A., Von Holle, A., Hamer, R. M., La Via, M., & Bulik, C. M. (2013). A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and Chromium (BEACh) study. Journal of psychosomatic research, 75(1), 36–42.
  11. Pei D, Hsieh CH, Hung YJ, Li JC, Lee CH, Kuo SW. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism. 2006 Jul;55(7):923-7.