NAD+ SCIENCE
NAD+ plays an essential role in cellular processes that protect us from ageing and disease. But as we age, our NAD+ levels decrease. Through breakthrough scientific innovation, it is now possible to replenish and maintain youthful NAD+ levels.
what is NAD+?
NAD+ is found in every cell of your body.
NAD+, or nicotinamide adenine dinucleotide, is a coenzyme that naturally occurs in the cells of all living organisms, from fruit flies to humans. Mitochondria‒the energy generators of cells‒require NAD+ to function well. NAD+ also helps convert nutrients from the foods you eat into energy and plays a crucial role in maintaining DNA health and regulating cellular function. These processes work together to lessen the effects of ageing and disease on your body.
HOW DOES NAD+ SUPPORT LONGEVITY?
Increasing NAD+ shows promise for extending healthspan and lifespan.
As you age, your NAD+ levels decrease dramatically, increasing the likelihood of faster ageing, heart disease, metabolic disorders, such as diabetes, neurodegenerative conditions, such as Alzheimer’s disease, and other age-related diseases.
Now, the good news: Replenishing NAD+ levels with precursors, such as NMN (nicotinamide mononucleotide), has demonstrated long-term health benefits. The effect shows promise for reversing age-related diseases, and increasing lifespan and healthspan—the number of healthy, disease-free years of your life.
THE HISTORY OF NAD+
NAD+ has been one of the most researched molecules in biology and medicine ever since its discovery in 1906, and in recent years, scientists have explored increasing NAD+ levels with supplements. Here’s the abbreviated history of NAD+.
THE ROLE OF NAD+
NAD+ is essential for all your cellular processes.
NAD+ works as a shuttle bus within your cells, transferring electrons from one molecule to another to perform various reactions and processes. For example, NAD+ is particularly important for energy generation.
NAD+ also serves as fuel to activate sirtuins, a family of proteins connected to healthy ageing and longevity. Sirtuins use NAD+ to regulate metabolism, maintain genomic stability, and repair damaged DNA.
The Role of NAD+
NAD+ works as a shuttle bus within your cells, transferring electrons from one molecule to another to perform various reactions and processes. For example, NAD+ is particularly important for energy generation.
NAD+ also serves as fuel to activate sirtuins, a family of proteins connected to healthy ageing and longevity. Sirtuins use NAD+ to regulate metabolism, maintain genomic stability, and repair damaged DNA.
NAD+ can also stabilise telomeres, the repetitive DNA sequences that act as protective caps at the ends of chromosomes—similar to the tips of a shoelace. Telomeres shorten each time a cell divides, ensuring that cells can only divide a limited number of times. But when telomeres become too short and cells can no longer divide, the result is senescence, or cell death—a process that contributes to ageing and disease.
Other functions of NAD+ include neurotransmitter synthesis, extracellular signalling, and regulating our circadian rhythm, which controls our body’s sleep/wake cycle.
REPLENISH AND MAINTAIN NAD+ LEVELS
It is now possible to replenish and maintain youthful NAD+ levels.
Maintaining NAD+ Levels
Healthy habits and supplementation are key to replenishing and maintaining your NAD+ levels and, in combination, can lead to optimal results. Longevity research recommends a balanced and primarily plant-based diet, regular exercise—especially high-intensity interval training, intermittent fasting (check with your doctor first), and regular heat therapy, such as through a sauna or steam room.
Beyond lifestyle factors, supplementation can further increase your body’s NAD+ levels in two ways. First, through the intake of a direct NAD+ precursor molecule such as NMN, and second, by inhibiting the enzymes that break down NAD+, with the help of ingredients like apigenin.
Both of our products, NMN and the Booster, tackle these two methods, and when combined, act as a powerful NAD+ boosting duo.
BUNDLE
Prevent and repair the hallmarks of ageing with this powerful combo
Get the best of both NAD+ supporting supplements. The Booster and the NMN are a powerful duo of high-quality, bioavailable ingredients that target diverse mechanisms of ageing at the cellular level, leaving you feeling more energized, youthful, and vibrant. Our NMN capsule contains 250 mg of Uthever® NMN, and our Booster combines 400 mg of active ingredients, including resveratrol, betaine, and more.
References
- Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell metabolism, 27(3), 529–547. https://doi.org/10.1016/j.cmet.2018.02.011
- North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michan, S., Dai, J., Baker, D. J., Cen, Y., Wu, L. E., Sauve, A. A., van Deursen, J. M., Rosenzweig, A., & Sinclair, D. A. (2014). SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO journal, 33(13), 1438–1453. https://doi.org/10.15252/embj.201386907
- Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V., Aravind, L., Steegborn, C., & Sinclair, D. A. (2017). A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.), 355(6331), 1312–1317. https://doi.org/10.1126/science.aad8242
- Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., Csiszar, A., & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. GeroScience, 42(2), 527–546. https://doi.org/10.1007/s11357-020-00165-5
- Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S. I., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science (New York, N.Y.), 372(6547), 1224–1229. https://doi.org/10.1126/science.abe9985
- Poljsak, B., Kovač, V., & Milisav, I. (2020). Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?. Oxidative medicine and cellular longevity, 2020, 8819627. https://doi.org/10.1155/2020/8819627