skin longevity 101

Why your collagen supplement might not be working – and what actually does

Most conversations around skin ageing acknowledge collagen loss, but few explore what it really means, or the solutions available to address it.

Collagen isn’t just a beauty buzzword - it’s the body’s primary structural protein which forms the scaffolding that gives skin its firmness, elasticity and smooth texture.

Unfortunately, from our mid-20s onwards, the body’s natural collagen production begins to decline by about 1% each year. This decrease accelerates further in our 40s and beyond, contributing to a gradual weakening of the skin’s structural integrity. At the same time, external environmental stressors such as UV radiation, pollution, and oxidative stress increase the rate at which existing collagen is broken down.

This combination of slowed production and increased breakdown is what in turn weakens the skin’s internal structure, thus leading to visible signs of skin ageing - thinning of the dermal matrix, diminished elasticity, and a noticeable loss of firmness and hydration. These internal changes manifest externally as fine lines, wrinkles, sagging, and dullness.

While many skincare routines focus on surface-level hydration and temporary plumping, these interventions do not address the root cause: the declining ability of the skin to produce and maintain collagen from within.

Why most collagen supplements are not effective for true collagen synthesis

Collagen is essential to skin health, but supplementing with collagen doesn’t guarantee that your body will use it in the way you hope. Most traditional collagen supplements don’t stimulate collagen production at all - not because collagen itself is ineffective, but because it needs the right amino acid profile, delivered with the necessary co-factors, to initiate and sustain collagen synthesis.

Traditional collagen powders and drinks often rely on hydrolysed animal collagen, which are fragments of protein broken down into peptides.

Once ingested, these peptides must be further digested, absorbed, and redistributed. But the body doesn’t always prioritise skin, so these peptides may end up supporting muscle tissue, liver function, or simply be used as general dietary protein. What they rarely do is signal the body to make new collagen where it matters: in the skin.

True collagen synthesis thus is a complex biological process that depends on three critical components:

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1. Specific amino acids in clinically relevant ratios

Collagen is predominantly composed of three amino acids: glycine, proline, and hydroxyproline. While these building blocks can be derived from dietary protein, effective collagen synthesis requires them in precise ratios that mirror the body’s natural collagen structure.

Generic protein powders or fragmented peptides often lack this specificity, limiting their potential to contribute meaningfully to new collagen formation within the skin.

2. Activation of fibroblasts - the body’s collagen-producing cells

Collagen is synthesised by fibroblasts, specialised cells within the dermis which play a central role in skin regeneration.

However, the presence of amino acids alone is not enough to trigger production. These cells require a biological signal - a trigger that prompts them to initiate collagen synthesis. Without this activation, the body lacks the instruction to begin rebuilding, even when all necessary components are present.

3. Essential co-factors to enable and stabilise collagen synthesis
The process of collagen formation is enzymatically complex and cannot proceed efficiently without certain nutritional co-factors. Nutrients such as Vitamin C and Alpha-Ketoglutarate (AKG) are indispensable for key stages of synthesis: from the hydroxylation of amino acids to the cross-linking of collagen fibres that gives the matrix its tensile strength. In the absence of these co-factors, collagen strands may remain unstable, poorly formed, and prone to rapid degradation.

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What to look for in a collagen supplement if you want real, scientifically backed results

If collagen loss is one of the root causes of skin ageing, it makes sense to try and restore it. But not all supplements are created equal - most fail to provide the conditions your body actually needs to rebuild collagen in a meaningful way.

For a collagen supplement to truly support skin health, it should offer a comprehensive system that supports each stage of the collagen synthesis process - from initiating production, to assembling and stabilising new collagen fibres.

Here’s what to look for:

1. A complete amino acid profile with collagen-specific precursors
Look for a supplement that delivers the core building blocks of collagen - glycine, proline, and hydroxyproline - in the correct ratio and form. These amino acids are essential for forming the triple helix structure of collagen, and they must be provided in a bioavailable format that the body can effectively absorb and utilise.

2. Key co-factors that enable collagen synthesis
Collagen production is enzymatically driven, which means it relies on co-factors to make the process work. Vitamin C is critical for converting proline into hydroxyproline - a necessary step for collagen stability - while Alpha-Ketoglutarate (AKG) supports collagen cross-linking and cellular energy metabolism. Without these, even the best amino acid profile will fall short.

3. Biological activators to trigger collagen production

Providing ingredients that activate the body’s natural collagen-producing pathways such as phytonutrients or longevity molecules is key. These compounds serve as the biological “on switch” for fibroblasts, signalling them to begin synthesising new collagen rather than waiting passively for raw materials to accumulate.

4. Clinically studied ingredients with proven efficacy

Always look for branded or standardised ingredients that are backed by human clinical trials. This ensures not only safety and consistency, but also that the supplement delivers measurable results, such as increased skin hydration, improved elasticity, or visible wrinkle reduction.

5. Clean, bioavailable, and ethically sourced formulations

Finally, a high-quality collagen supplement should be clean-label: free from unnecessary fillers, sugars, and synthetic additives. For those seeking plant-based or ethical alternatives, vegan collagen precursors offer a modern approach - delivering results without relying on animal-derived collagen peptides, which are often poorly absorbed and inconsistently processed.

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The latest innovation in skin longevity research has been this 100% vegan, patented collagen pre-cursor

Recent advancements in skin longevity research have thus shifted the focus from simply supplementing collagen to stimulating the body’s own ability to produce it. While traditional collagen supplements deliver hydrolysed protein fragments, they often fall short in triggering true collagen synthesis, especially in the skin, where structural integrity and long-term skin health depend on more factors.

At the forefront of this new approach has been a next-generation, 100% vegan collagen precursor developed in collaboration with longevity researchers at ETZ Zurich, designed to support the full lifecycle of collagen production: from providing essential building blocks to activating synthesis and protecting newly formed collagen fibres.

Central to this innovation is Colgevity™, a patented plant-based complex that delivers the three key amino acids required for collagen formation - glycine, proline, and hydroxyproline - in the precise ratio needed to form collagen’s stable triple helix structure.

To enhance its efficacy, this precursor has been combined with key co-factors in a formulation known as the Collagen Activator - a more complete and science-based approach to collagen support:

Vitamin C from Acerola Cherry serves as a critical co-factor for hydroxylation, the enzymatic step that stabilises newly formed collagen fibres.
Alpha-Ketoglutarate (AKG), a longevity-associated molecule, supports mitochondrial energy metabolism and facilitates collagen cross-linking, helping ensure the collagen produced is not only abundant but structurally resilient.
And because preserving existing collagen is just as important as stimulating new production, the formulation also includes Astaxanthin - a powerful antioxidant clinically shown to protect the skin from oxidative stress and UV-induced collagen degradation.

Together, these components represent a scientifically grounded, multi-step solution to collagen support - targeting not only synthesis, but also structural stability and long-term protection, making it one of the most advanced formulations in the field of skin longevity.

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Collagen Activator

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Title

Formulated with longevity researchers at ETH Zurich, our patented, 100% vegan complex stimulates your body's natural collagen production 4x more effectively than traditional collagen peptides.

✔ Developed by leading longevity experts in Switzerland

✔ 100% vegan, clean, transparent ingredients with no sugar, toxins, or fillers. Sweetened with Stevia.

✔ Backed by 500+ extensive studies. Clinically validated to improve skin hydration and texture within just 30 days.

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Mirela B.C. | Age: 34 | 4 months

I use Vitality bundle and Collagen activator. Skin texture improved, energy level increased, better sleep quality. Definitely both products will stay in my daily routine in the future.

Gerrit M. | Age: 28 | 3 months

It seems I need to cut my nails twice as often as previously, and my skin feels softer and smoother than ever before.

Karin T. | Age: 28 | 1 months

The skin looks and feels better after almost 1 month.

Maria | Age: 44 | 4 months

I am very satisfied with the Collagen Activator. It has a pleasant taste and gives me physical strength.

Liesbet. | Age: 26 | 1 months

After a month of collagen I already see improvements in my skin which just looks more even and plump somehow.

benefits

Stimulates collagen production

Research conducted at ETH Zurich showed that our vegan collagen precursor compound, Colgevity™, in our Collagen Activator, increases collagen synthesis 4x more than regular collagen intake.*

*Based on an in vitro study in human skin cells and model organisms.

Boosts skin hydration from within

Elevate your skin's moisture levels with our Collagen Activator. Clinically observed to boost skin hydration by 95%, it leaves the complexion deeply moisturised and resilient.

Improves skin texture & smoothness

Our Collagen Activator effectively refines skin texture, offering a significant reduction in pore appearance by 9% and enhancing smoothness by 21%, resulting in a polished and refined complexion.

Enhances skin protection against UV damage

Studies suggest astaxanthin supplementation may inhibit age-related skin deterioration and maintain skin conditions associated with environmentally induced damage via its anti-inflammatory effect.

Promotes healthy joints by supporting cartilage growth
All ingredients in our Collagen Activator have been shown to either increase or protect collagen levels as well as reduce inflammation which contributes to joint health by slowing cartilage wear down.

May reduce biological age over time

Numerous studies, including ours, show that AKG can extend lifespan in various organisms. A human study showed significant biological age reduction after supplementing for 7 months with 1g Ca-AKG.

ingredients

Active ingredients:

Colgevity™ 8400mg (L-Glycine 5000mg, L-Hydroxyproline 1700mg, L-Proline 1700mg), Calcium Alpha-Ketoglutarate 1000mg, Algae Powder 200mg (Providing Astaxanthin 4mg), Acerola Fruit Juice Extract 150mg (Providing Vitamin C 48mg)

Other ingredients:

Silicon dioxide as anti-caking agent to ensure the powder’s free-flowing nature, improve manufacturing processes, maintain ingredient uniformity and enhance the stability of the final product
Citric acid as acidity regulator to stabilize pH, enhance flavor, improve solubility, prevent microbial growth and protect the product’s active ingredients, ensuring a high-quality and enjoyable final product
Steviol glycosides from stevia as sweetener to serve as a natural, calorie-free sweetener that enhances the taste, masks unpleasant flavors and improves the palatability of drinks while being suitable for various dietary preferences and restrictions
Natural raspberry flavours as flavour to enhance taste, mask unpleasant notes, improve consumer appeal and encourage regular consumption of the product (included only in Collagen Activator Lemon Raspberry)
Peppermint oil powder as flavour to improve taste, mask undesirable flavors, provide a refreshing cooling effect and enhance the sensory experience (included only in Collagen Activator Lemon Raspberry)
Safflower concentrate (carthamus) as colouring food to enhance visual appeal, standardize product appearance and align with consumer preferences for clean-label, plant-based ingredients (included only in Collagen Activator Lemon)
Natural lemon flavour as flavour to enhance taste, mask unpleasant notes, improve consumer appeal and encourage regular consumption of the product (included only in Collagen Activator Lemon)

sourcing

At Avea, we prioritise transparency and quality. We source globally, focusing on ingredients with excellent bioavailability or high activity through standardised plant extracts. Every batch is rigorously double-tested for purity by an independent Swiss lab. We go beyond standard labelling to provide detailed information, and our customer service team is available for any questions or test result requests.

daily intake guide

Take one daily Collagen Activator sachet dissolved in a glass of water, preferably after a meal or 1-2 hours before bed to promote skin rejuvenation and support restorative sleep thanks to its Glycine content.

100% vegan

clean, traceable ingredients

third-party double tested in switzerland

backed by 500+ studies

no artificial flavours, fillers or additives

Did you know? The impact of collagen can be measured

Less dots = improved skin texture by 73%

Before

After

The effectiveness of collagen support is no longer just anecdotal, it can now be objectively measured using advanced imaging technologies.

To assess visible skin improvements, researchers used Visia® Skin Analysis - a gold-standard clinical imaging system that quantifies changes in texture, hydration, elasticity, and wrinkle depth.

Over a 90-day period, women taking the Collagen Activator daily were evaluated using this technology. The results showed measurable improvements in skin firmness, deep hydration, and overall skin quality.

For detailed before-and-after results, the full clinical case study can be accessed here.

Complete your Skin Longevity Routine by preserving the collagen you’ve built

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Stimulating collagen production is a critical first step in addressing the signs of skin ageing, but it’s only one part of a much more complex picture. For collagen to deliver lasting structural and aesthetic benefits, it must also be preserved. This means protecting it not only from external factors such as UV radiation and pollution, but also from the internal biological processes that accelerate its breakdown over time.

Yet collagen alone does not define skin longevity.

An equally essential - and often overlooked - component is the skin barrier.

This outermost layer of the skin is a dynamic, lipid-based structure composed of ceramides, fatty acids, and tightly packed skin cells. While often associated with hydration and glow, its function is far more foundational. The skin barrier plays a central role in maintaining overall skin health: it regulates moisture levels, prevents transepidermal water loss, and serves as the body’s first line of defence against irritants, pathogens, and oxidative stress.

As the skin ages, this barrier becomes increasingly compromised - production of natural ceramides and hyaluronic acid declines, cellular turnover slows (from 28 to over 80 days), and the barrier’s ability to retain hydration and resist environmental damage diminishes. These shifts do more than increase sensitivity or dryness - they create conditions that accelerate collagen degradation and impair the skin’s ability to regenerate itself.

What’s more, these barrier-related changes often begin before visible collagen loss occurs, and can significantly limit the effectiveness of even the most advanced collagen-support formulas.

This is precisely why we recently launched our newest formula for supporting skin longevity - SkinSpan™.

Created in collaboration with longevity researchers in Switzerland, SkinSpan™ was designed to complement the Collagen Activator by addressing the underlying causes of collagen breakdown. It works from within to strengthen the skin barrier, restore hydration at a deep level, and support healthy cell renewal - three essential processes that help protect collagen and extend its impact.

Together, Collagen Activator and SkinSpan™ offer a comprehensive approach to skin longevity:

– Collagen Activator stimulates collagen production at the source
– SkinSpan™ preserves and protects that collagen by reinforcing the skin’s outer defences - the skin barrier

Used together, they provide a holistic and clinically supported strategy for true skin longevity - targeting both the production and preservation of collagen while also reinforcing the skin’s natural regenerative systems.

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About the Author

Dr. Matilde Mantovani

Molecular Biologist & Scientific Research Manager

Matilde possesses a strong academic experience as she holds a Ph.D. in Molecular Life Sciences from the University of Zurich.

Her research focused on understanding how error during protein synthesis can impact our health and contribute to ageing.

She combines her scientific background with a passion for photography, volunteering as a photographer in various events that aim to connect science and society.

We want you to ask questions.

Our team of longevity experts and scientists have answers. Can't find what you're looking for? Visit our Help Centre - we will be happy to help you.

Which Avea product is best for me?

To find the Avea product that's right for you, we recommend you take our personalised quiz. By entering your health goals and personal data, you will receive customised product recommendations based on the latest scientific findings from our Longevity experts.

How long does it take to see results with Avea products?

Results vary depending on the product and individual factors such as lifestyle, diet and regular use. While some users notice changes after just a few weeks, long-term benefits are best achieved through continued use according to the recommendations.

Are Avea products vegan and allergen-free?

Many Avea products are vegan, gluten-free and free from common allergens. However, we recommend checking the ingredients list on the product page or packaging to ensure that the product meets your dietary preferences and restrictions.

Can I use several Avea products at the same time?

Yes, Avea products are formulated to work together synergistically. However, we recommend that you follow the instructions for use and consult a doctor if you have any concerns about combining different supplements.

How should I store Avea products to preserve their quality?

To preserve the effectiveness and shelf life of Avea products, they should be stored in a cool, dry place away from direct sunlight or heat. Some products need to be refrigerated after opening - please follow the specific storage instructions on the packaging.

The Avea Promise

We carefully select the purest and most bioavailable plant extracts and compounds available. Our product descriptions clearly outline the production methods and origins of each ingredient.

made in switzerland

We manufacture in state-of-the-art, GMP-certified facilities that are regularly audited by Swiss authorities. Each product batch is sent to an independent Swiss laboratory for additional purity testing, ensuring the highest quality and safety.

backed by science

Our formulations are based on cutting-edge Longevity research. Led by Chief Science Officer Sophie Chabloz, our team collaborates with longevity experts from top institutions to create highly effective, science-backed products.

transparent ingredients

We carefully select the purest and most bioavailable plant extracts and compounds available. Our product descriptions clearly outline the production methods and origins of each ingredient.