Top biohackers boosting longevity beyond Bryan Johnson: their must-have supplements and lifestyle hacks

Are we the first generation that won’t die? Bryan Johnson, the subject of Netflix’s ‘’Don’t Die: The Man Who Wants to Live Forever’’, believes so. 


The 47-year-old multimillionaire, also a tech entrepreneur, has turned his body into a $2 million-per-year experiment to slow ageing, claiming a biological age of 31 and the VO2 max of an elite 18-year-old. 


With his expert-created Blueprint lifestyle, featuring a strict diet, exercise, and sleep regimen—Johnson claims to have slowed his biological ageing rate to 0.64, essentially ageing only seven and a half months per year.


While most people are skeptical about his routines, Bryan Johnson represents just one extreme in the diverse world of biohacking. Because, longevity is much more than ‘’not dying’’, it’s about ‘’healthy ageing’’.


For those seeking longevity, there are other biohackers who offer actionable, science-backed strategies grounded in research. 


From Harvard professors to medical innovators, these experts practise what they preach with practical habits, targeted supplements, and accessible routines that align with modern lifestyles.


In this Avea article, we spotlight 6 biohackers—three male and three female—shaping the future of healthy ageing. Discover their daily hacks, supplements, and must-read books to boost your longevity—all without breaking the bank.

Leading biohackers you should know about

1. David Sinclair

Dr. David Sinclair is a renowned Harvard geneticist and one of the leading figures in anti-ageing research. As the author of Lifespan: Why We Age and Why We Don’t Have To, he explores the science behind slowing the ageing process and extending healthspan.

Lifestyle hacks

Intermittent fasting and a predominantly plant-based diet.

Regular exercise to maintain cellular health and metabolic function.

Cold exposure therapy to promote resilience and reduce inflammation.

Avoiding excess sugar and processed foods to prevent metabolic dysfunction.

Anti-ageing supplements to take

Sinclair incorporates cutting-edge supplements like NAD+ precursor, Resveratrol, Vitamin D to support overall health. Discover his whole list of supplements he takes daily.

Longevity books to read

Sinclair recommends his own bestseller, Lifespan, and The Blue Zones by Dan Buettner, which examines the habits of the world’s longest-living populations.

2. Andrew Huberman

Dr. Andrew Huberman is a Stanford neuroscientist, renowned for his work on brain health and human performance. He hosts the popular Huberman Lab podcast, where he shares evidence-based insights into biohacking and optimising health.

Lifestyle hacks

Morning sunlight exposure to regulate circadian rhythms and boost mood.

Prioritising high-quality sleep through structured routines and environmental adjustments.

Incorporating breathwork exercises to manage stress and enhance focus.

Using temperature extremes, such as saunas and ice baths, to improve resilience and recovery.

Anti-ageing supplements to take

Huberman often discusses the benefits of NAD+ precursors, Apigenin and Magnesium for brain health and sleep, L-theanine for relaxation and focus, and Omega-3 fatty acids for overall cognitive and cardiovascular health. Explore his complete list of daily supplements.

Longevity books to read

He often recommends Why We Sleep by Matthew Walker to explore the importance of quality sleep and Atomic Habits by James Clear for mastering habit formation. You can find summaries of both books here:

Why We Sleep

Atomic Habits

3. Peter Attia

Dr. Peter Attia is a longevity-focused physician and the bestselling author of Outlive: The Science and Art of Longevity. His work emphasises metabolic health, disease prevention, and maximising lifespan through science-backed strategies.

Lifestyle hacks

Zone 2 cardio to optimise cardiovascular health and fat metabolism.

Strength training to preserve muscle mass and maintain physical function.

Tracking biomarkers like blood glucose and lipids to make data-driven health decisions.

Following a nutrient-dense diet that avoids processed carbohydrates to prevent metabolic dysfunction.

Anti-ageing supplements to take

Attia advocates for Omega-3 fatty acids  for heart and brain health, Magnesium, Vitamin K2 and Glycine, amongst others. Explore his Peter Attia’s 6 main pillars of longevity.

Longevity books to read

His own book, Outlive, provides a comprehensive guide to living longer and healthier. He also recommends The Art of Learning by Josh Waitzkin, which delves into mastering skills and achieving peak performance.
Discover the top 10 male biohackers you should know about in 2025.

The best supplements for longevity

​​Avea’s Vitality Bundle is a scientifically engineered solution designed to support longevity at the cellular level. 

This powerful duo combines a NAD+ precursor, as popularised by Dr. David Sinclair and Dr. Andrew Huberman, with an advanced NAD+ Booster featuring ingredients that work in synergy to optimise your NAD+ levels.

Why should you boost your NAD+ levels?

NAD+ is vital for energy, cell repair, metabolism, and overall longevity, but levels decline with age, impacting vitality. 


While the NAD+ precursor lays the foundation for increasing NAD+ levels, studies show that a holistic approach enhances its impact.


To optimise NAD+ metabolism, you need to:
✔ Boost NAD+ production and utilisation
✔ Protect against NAD+ degradation
✔ Enhance NAD+ recycling


Hours of research led to the development of the Avea Vitality Bundle. We pair NMN with our Booster as:


🔹 Resveratrol & Pterostilbene – Activate sirtuins for efficient NAD+ use
🔹 CoQ10 – Supports mitochondria & shields against oxidative stress
🔹 Apigenin – Inhibits CD38 to prevent NAD+ breakdown
🔹 Betaine – Helps NAD+ recycling, ensuring stability under stress
🔹 Nicotinamide – Provides essential raw materials for NAD+ production


This comprehensive approach tackles every aspect of NAD+ metabolism, delivering:

  • Sustained energy
  • Faster recovery
  • Sharper focus
  • Improved sleep
  • Long-term health resilience

4. Jessie Inchauspé (Glucose Goddess)

Jessie Inchauspé, popularly known as the Glucose Goddess, is a biochemist and bestselling author focused on glucose management as a cornerstone of health. Her mission is to make science-backed strategies accessible to improve energy, mood, and long-term wellbeing.

Lifestyle hacks

Flatten glucose spikes by eating fibre-rich foods before carbohydrates.

Encourage light walking after meals to stabilise blood sugar levels.

Minimise sugar and processed foods while prioritising balanced, whole-food meals.

Discover the 10 glucose goddess hacks to balance your blood sugar levels.

Anti-ageing supplements to take

The Glucose Goddess has been highlighting the convenience of anti-spike pills to flatten glucose curves.

Longevity books to read

She is the author of Glucose Revolution, a guide to managing blood sugar through small, practical changes. She also recommends The Blue Zones by Dan Buettner to explore the habits of the world’s healthiest populations.
Learn why glucose spikes are harmful with this summary from Glucose Revolution.

5. Amy Killen

Dr. Amy Killen is a physician specialising in regenerative medicine and skincare biohacking. Known for her innovative approaches to anti-ageing and longevity, she empowers people to optimise their health from the inside out, with a particular focus on skin and sexual health.

Lifestyle hacks

Biohacks for skin health, such as red light therapy and micro-needling, to boost collagen production.

Prioritising hydration and quality sleep to maintain overall skin vitality.

Supporting longevity with collagen-rich diets and anti-inflammatory practices.

Anti-ageing supplements to take

Killen incorporates collagen peptides to enhance skin elasticity, hyaluronic acid for hydration, and NAD+ precursors to promote cellular repair and energy.


Discover the difference between collagen peptides and collagen amino acids.

Longevity books to read

She recommends Boundless by Ben Greenfield, which explores advanced biohacking techniques, and Younger by Dr. Sara Gottfried, a guide to reversing the effects of ageing on the body.

6. Ayesha Sherzai 

Dr. Ayesha Sherzai is a neurologist and co-author of The Alzheimer’s Solution. Alongside her husband, Dr. Dean Sherzai, she champions brain health and lifestyle strategies for preventing cognitive decline and enhancing longevity.

Lifestyle hacks

Following a plant-rich, nutrient-dense diet to support brain function.

Incorporating mindfulness practices like meditation to reduce stress and boost focus.

Engaging in regular cognitive stimulation, such as learning new skills or puzzles, to keep the brain active.

Regular physical movement, including walking and yoga, for both brain and body health.

Learn how to exercise for longevity with advice from 4 experts.

Anti-ageing supplements to take

Sherzai recommends DHA-rich Omega-3s for cognitive health, Curcumin for its anti-inflammatory properties, and B-complex vitamins to support brain function and energy metabolism.

 

Discover the top 10 female biohackers you should know about in 2025.

Longevity books to read

She is the co-author of The Alzheimer’s Solution, a comprehensive guide to preventing and managing cognitive decline. She also suggests Ikigai by Héctor García, which explores the Japanese concept of finding purpose as a key to longevity and happiness.


Here’s the list of the top 15 longevity books to read in 2025.

What do all those biohackers have in common?

Despite their unique methods, all these biohackers share a commitment to longevity through:

Diet optimisation: Emphasise plant-based eating, glucose management, and cutting out processed foods. Learn how to build a longevity diet.

Prioritising sleep: Follow routines that enhance restorative rest and improve overall health. Learn how to build the best sleep routine from Bryan Johnson.

Glucose regulation: Start your meals with fibres, proteins, and lastly carbs. Exercise regularly to stabilise your energy and reduce unwanted inflammation.

Targeted supplements: Include supplements like Omega-3s, NAD+ precursors, Magnesium, and other natural compounds daily to support your cellular health.

Consistency: Track your biomarkers and personalise habits to align with your needs.

What you should know about biohacking?

These biohacking pioneers demonstrate that longevity is more than just extending life—it’s about improving its quality. Biohackers go beyond what traditional medicine offers, and aim to boost their potential to a 100%.


At its very core, biohacking is the practice of modifying your body and mind to improve their function.


While some may link biohacking with futuristic implants and extreme interventions like Bryan Johnson, the reality is that biohacking is far more accessible. It can be from basic lifestyle adjustments to the use of cutting-edge technology like supplements.


This concept is rooted in the idea that we are not just passive recipients of our genetic makeup or environmental influences, but active participants in shaping our own biology. It’s a form of self-improvement.

‘’80% of your health in old age is up to you.’’
Dr. David Sinclair.
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