NMN SCIENCE
NMN is an essential building block of NAD+.NMN targets the natural decline of NAD+ in our bodies as we age to support vibrant health.
WHAT IS NMN?
NMN is a potent NAD+ precursor.
NMN, short for nicotinamide mononucleotide, is a naturally occurring vitamin B3 derivative and a building block, known as a precursor, of NAD+ (nicotinamide adenine dinucleotide). NAD+ is an essential coenzyme present in all living cells that plays a role in protecting us from the effects of ageing and disease. But, unfortunately, NAD+ declines as we age.
That’s where NMN comes in. By targeting the natural decline of NAD+ in our bodies, NMN replenishes NAD+ levels and helps you maintain vibrant health for longer.
At Avea, our NMN supplement is a powerful high-quality formulation that targets the diverse mechanisms of ageing at the cellular level. Our supplement is third-party tested for purity and contains Uthever® NMN, a brand recognized for its top quality and safety, as well as less temperature sensitivity and more bioavailability than other NMN brands.
Our NMN supplement has shown promising results in a recent randomised, double-blind, controlled clinical trial to evaluate its efficacy and safety.
The Science Behind NMN
NMN
What is it: A naturally occurring vitamin B3 derivative and a precursor of NAD+, an essential coenzyme present in all living cells that is closely linked to metabolism and ageing.
What it does: Targets the natural decline of NAD+ in our bodies as we age. By restoring NAD+ levels, NMN helps you regain and maintain vibrant health and energy.
What is NMN?
NMN, short for nicotinamide mononucleotide, is a naturally occurring vitamin B3 derivative. NMN is a precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme present in all human cells. NAD+ is essential for life and is linked closely to metabolism and ageing.
Where can it be found in nature?
NMN is naturally present in our food, including milk, meat, avocado, broccoli, cabbage, cucumber, and edamame. However, it would be nearly impossible to get an efficient dose from food alone. You’d need to consume almost 100kg of broccoli or 416kg of beef just to get 250mg of NMN, the dose provided in our daily supplement.
What are its primary functions?
NMN becomes NAD+ in our bodies, and NAD+ is involved in hundreds of metabolic processes throughout the body. Its most crucial roles include helping turn nutrients into energy and working as a fuel for the enzymes involved in DNA protection and repair. Accumulating evidence suggests that NAD+ systemically declines with age and contributes to the development of age-related diseases. A 50-year-old, for example, has roughly half the levels of NAD+ as a 20-year-old. Of course, you can live with low levels of NAD+, but it will accelerate the ageing process and reduce your healthspan. Fortunately, increasing NAD+ levels has many health benefits for various organs, including the brain, cardiovascular system, and skin elasticity.
What are the benefits of taking NMN?
NMN targets the natural decline of NAD+ in our bodies as we age. By restoring NAD+ levels, NMN supplements help you regain, sustain, and maintain vibrant health and energy through the years. A number of studies have shown the beneficial effects of NMN on energy levels, memory, blood vessel health, metabolism, stem cell health, epigenome maintenance, and DNA damage repair. In a clinical study in 2014, for instance, a team of researchers led by Dr. David Sinclair, professor of genetics at Harvard Medical School and expert on biological ageing, demonstrated that NMN can extend lifespan, and a later study showed that NMN increases NAD+ levels and reverses DNA damage.
Why do we use NMN in our supplements?
NMN is one of the most promising supplements for slowing ageing. Since NMN gets converted into NAD+ in our cells, it can effectively replenish NAD+, helping you regain your health and energy to youthful levels. NMN is proven to be safe, stable, and effective. Continuous clinical trials demonstrate and unveil more of its benefits.
Sources
- Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell metabolism, 27(3), 529–547. https://doi.org/10.1016/j.cmet.2018.02.011
- North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michan, S., Dai, J., Baker, D. J., Cen, Y., Wu, L. E., Sauve, A. A., van Deursen, J. M., Rosenzweig, A., & Sinclair, D. A. (2014). SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO journal, 33(13), 1438–1453. https://doi.org/10.15252/embj.201386907
- Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V., Aravind, L., Steegborn, C., & Sinclair, D. A. (2017). A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.), 355(6331), 1312–1317. https://doi.org/10.1126/science.aad8242
- Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., Csiszar, A., & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. GeroScience, 42(2), 527–546. https://doi.org/10.1007/s11357-020-00165-5
- Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S. I., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science (New York, N.Y.), 372(6547), 1224–1229. https://doi.org/10.1126/science.abe9985
NMN AND NAD+ LONGEVITY
NMN replenishes NAD+ and counteracts the effects of ageing.
NMN and NAD+ Longevity
One example of the critical role NAD+ plays in the body is connection to sirtuins, a family of enzymes connected to healthy ageing and longevity. Sirtuins rely on NAD+ to regulate metabolism, repair damaged DNA, and maintain the epigenome.
The epigenome is a mix of chemical compounds and proteins surrounding your DNA that, together, direct actions that turn your genes on or off and control the production of proteins in particular cells. With age, the epigenome becomes more dysregulated. This dysregulation can result in the switching off of genes that are still required, such as housekeeping genes. On the other hand, it may also result in switching on genes that promote cancer or stimulate inflammation.
NAD+ is also needed to fuel PARPs, short for poly-ADP ribose polymerases. PARPs are another crucial family of enzymes that help repair DNA damage in your cells. When NAD+ levels are too low, our DNA can become damaged which can then lead to accelerated ageing and disease.
Research shows that NMN improves the functioning of our mitochondria, the power plants of our cells. Mitochondria provide almost all the energy that our cells need in order to function and survive. However, as we age, our mitochondria become less efficient or even damaged, resulting in a host of health issues.
NMN can also decrease age-related levels of inflammation in the body by inhibiting inflammatory macrophage responses (a white-blood-cell activity) and by limiting the accumulation of inflammation-associated proteins.
Finally, NMN can rejuvenate stem cell health, helping your body’s stem cells not only live longer and replicate more, but counteract the decrease of stem cells that comes with ageing as well. Stems cells are important in health and longevity because they replace cells in the body that are damaged or lost.
NMN AND SCIENTIFIC STUDIES
NMN supplementation effectively targets the signs of ageing.
You can think of NAD+ as a type of fuel that helps many proteins and enzymes in your body carry out essential functions. NNM is a building block of this "fuel," meaning it is needed in order for your body to make NAD+.
NMN and Scientific Studies
Studies have shown the benefits of NMN supplementation on energy levels, memory, blood vessel health, metabolism, stem cell health, epigenome maintenance, and DNA damage repair in animals. NMN has been shown to mitigate multiple aspects of ageing in older animals, improving their metabolism, stamina, and fertility, and increasing blood flow to the brain.
In 2014, a team of researchers led by Dr. David Sinclair, a professor of genetics at Harvard and a world-class expert on ageing, demonstrated that NMN can extend the lifespan of mice. In 2017, Sinclair's team increased NAD+ levels in mice which reversed age-related DNA damage. Finally, in 2021, the first randomised clinical trial showed that humans who took 250mg of NMN daily increased their NAD+ levels and improved muscle insulin sensitivity. Muscle insulin sensitivity is a critical component of whole-body insulin resistance and in protection from ageing-related disease, including type type 2 diabetes, heart disease, and certain cancers.
NMN is well absorbed when taken orally and is also much more stable in the digestive system and bloodstream and, therefore more bioavailable, than other NAD+ boosters. Recent studies suggest that NMN is the most potent NAD+ booster for targeting the signs of ageing. This may explain why many ageing scientists, including Sinclair, not only promote research on NMN, they take it for their own health and longevity.
NMN
Regain your health, energy, and cellular functions to youthful levels.
Backed by science, NMN is safe and effective at slowing and even reversing ageing, increasing energy, and supporting nearly every organ in the body. Use it on its own or in tandem with the Booster for optimal results.
References
- Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell metabolism, 27(3), 529–547. https://doi.org/10.1016/j.cmet.2018.02.011
- North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michan, S., Dai, J., Baker, D. J., Cen, Y., Wu, L. E., Sauve, A. A., van Deursen, J. M., Rosenzweig, A., & Sinclair, D. A. (2014). SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO journal, 33(13), 1438–1453. https://doi.org/10.15252/embj.201386907
- Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V., Aravind, L., Steegborn, C., & Sinclair, D. A. (2017). A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.), 355(6331), 1312–1317. https://doi.org/10.1126/science.aad8242
- Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., Csiszar, A., & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. GeroScience, 42(2), 527–546. https://doi.org/10.1007/s11357-020-00165-5
- Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S. I., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science (New York, N.Y.), 372(6547), 1224–1229. https://doi.org/10.1126/science.abe9985